{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:35:16Z","timestamp":1791848116810,"version":"4.3.4"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK104344"],"award-info":[{"award-number":["DK104344"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL173059-01"],"award-info":[{"award-number":["1R01HL173059-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R56AI169645"],"award-info":[{"award-number":["R56AI169645"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020578","name":"Department of Jobs, Tourism, Science and Innovation, Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020578","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Pediatrics, Mass General for Children, Massachusetts General Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2025,7,4]]},"DOI":"10.1021\/acs.jproteome.5c00062","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:55:07Z","timestamp":1749516907000},"page":"3470-3483","source":"Crossref","is-referenced-by-count":7,"title":["Children with Post COVID-19 Multisystem Inflammatory Syndrome Display Unique Pathophysiological Metabolic Phenotypes"],"prefix":"10.1021","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9649-425X","authenticated-orcid":true,"given":"Nathan G.","family":"Lawler","sequence":"first","affiliation":[{"name":"Australian National Phenome Center, and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lael M.","family":"Yonker","sequence":"additional","affiliation":[{"name":"Department of Pediatrics","place":["Boston, United States"]},{"name":"Massachusetts General Hospital, Mucosal Immunology and Biology Research Center","place":["Boston, United States"]},{"name":"Harvard Medical School","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9193-0462","authenticated-orcid":true,"given":"Samantha","family":"Lodge","sequence":"additional","affiliation":[{"name":"Australian National Phenome Center, and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5814-7529","authenticated-orcid":true,"given":"Philipp","family":"Nitschke","sequence":"additional","affiliation":[{"name":"Australian National Phenome Center, and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen M.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Pediatrics","place":["Boston, United States"]},{"name":"Massachusetts General Hospital, Mucosal Immunology and Biology Research Center","place":["Boston, United States"]},{"name":"Harvard Medical School","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0094-5245","authenticated-orcid":true,"given":"Nicola","family":"Gray","sequence":"additional","affiliation":[{"name":"Australian National Phenome Center, and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9088-4799","authenticated-orcid":true,"given":"Luke","family":"Whiley","sequence":"additional","affiliation":[{"name":"Australian National Phenome Center, and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reika","family":"Masuda","sequence":"additional","affiliation":[{"name":"Australian National Phenome Center, and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-8389","authenticated-orcid":true,"given":"Elaine","family":"Holmes","sequence":"additional","affiliation":[{"name":"Australian National Phenome Center, and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia"},{"name":"Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-2572","authenticated-orcid":true,"given":"Julien","family":"Wist","sequence":"additional","affiliation":[{"name":"Australian National Phenome Center, and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia"},{"name":"Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K."},{"name":"Chemistry Department","place":["Cali, Colombia"]},{"name":"Universidad del Valle","place":["Cali, Colombia"]},{"name":"Institute of Global Health Innovation, Faculty of Medicine, Imperial College London, Level 1, Faculty Building, South Kensington Campus, London SW7 2NA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Fasano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics","place":["Boston, United States"]},{"name":"Massachusetts General Hospital, Mucosal Immunology and Biology Research Center","place":["Boston, United States"]},{"name":"Harvard Medical School","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-8349","authenticated-orcid":true,"given":"Jeremy K.","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Australian National Phenome Center, and Center for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, Western Australia 6150, Australia"},{"name":"Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K."},{"name":"Institute of Global Health Innovation, Faculty of Medicine, Imperial College London, Level 1, Faculty Building, South Kensington Campus, London SW7 2NA, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13495-5"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143840"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-093022-011839"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2021.01.008"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048360"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021756"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2022-325152"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00846-2"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01579-5"},{"key":"ref10\/cit10","unstructured":"WHO. World Health Organ. 2023. WHO COVID-19 dashboard. https:\/\/covid19.who.int (accessed\nApril 2024)."},{"key":"ref11\/cit11","unstructured":"CDCP.  CDC COVID Data Tracker: Pediatric Seroprevalence. https:\/\/covid.cdc.gov\/covid-data-tracker\/#pediatric-seroprevalence (accessed May 2024)."},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.026"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1113\/EP087159"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1105163"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-31082-0"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411614"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01380-2"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00224"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.0c00519"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00052"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.21037\/jlpm.2020.03.03"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c05389"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)07098-2"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-022-01056-8"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01689-3"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00044-4"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101619"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1007\/s43657-021-00020-3"},{"key":"ref29\/cit29","unstructured":"CDCP. Multisystem inflammatory syndrome in children\n(MIS-C). https:\/\/www.cdc.gov\/mis-c\/ (accessed April 2024)."},{"key":"ref30\/cit30","unstructured":"NIH. COVID-19 Treatment Guidelines Panel. Coronavirus Disease\n2019 (COVID-19) Treatment Guidelines. https:\/\/www.covid19treatmentguidelines.nih.gov\/ (accessed April 2024)."},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/ac5025039"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/ja055336t"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c04576"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121872"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.2c00682"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/ac981422i"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.9b00640"},{"key":"ref38\/cit38","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2023"},{"key":"ref39\/cit39","unstructured":"Grigoroff, L.; Wist, J. Mva.Plots: A Repository of Function to Visualize Results from Multivariate Models."},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr597"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/cem.695"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1530509100"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00458"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11070467"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx364"},{"key":"ref46\/cit46","unstructured":"Clinical Spectrum\n| COVID-19 Treatment Guidelines. https:\/\/www.covid19treatmentguidelines.nih.gov\/overview\/clinical-spectrum\/ (accessed June 2024)."},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.08.037"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.3c00797"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108313"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2023-1017"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1172\/JCI149633"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.113.000675"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.1"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-024-00796-0"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1186\/s43044-021-00150-z"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiab509"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43390-6"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2022.100848"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1172\/JCI151520"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaa213"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1326156"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2020.08.004"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3390\/children11101174"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06370-8"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000973"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.1.172"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56284-0"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00062","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T08:12:03Z","timestamp":1751616723000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.5c00062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,9]]},"references-count":68,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7,4]]}},"alternative-id":["10.1021\/acs.jproteome.5c00062"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.5c00062","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,9]]}}}