{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:30:18Z","timestamp":1778221818332,"version":"3.51.4"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103620"],"award-info":[{"award-number":["P20GM103620"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008522","name":"University of Illinois at Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008522","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"name":"RSH\/Smith-Lemli-Opitz Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2025,8,1]]},"DOI":"10.1021\/acs.jproteome.5c00282","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T14:02:19Z","timestamp":1752069739000},"page":"4154-4165","source":"Crossref","is-referenced-by-count":1,"title":["Altered Cerebrospinal Fluid Proteins in Smith\u2013Lemli\u2013Opitz Syndrome"],"prefix":"10.1021","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5917-5380","authenticated-orcid":true,"given":"Wenping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Chemistry","place":["Chicago, United States"]},{"name":"University of Illinois Chicago","place":["Chicago, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1197-4057","authenticated-orcid":true,"given":"Melissa R.","family":"Pergande","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Chicago, United States"]},{"name":"University of Illinois Chicago","place":["Chicago, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fidel","family":"Serna-Perez","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Chicago, United States"]},{"name":"University of Illinois Chicago","place":["Chicago, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinayak","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Chicago, United States"]},{"name":"University of Illinois Chicago","place":["Chicago, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Crutchfield","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine","place":["Bethesda, United States"]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian C.","family":"Searle","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics","place":["Columbus, United States"]},{"name":"The Ohio State University Medical Center","place":["Columbus, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline A.","family":"Picache","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine","place":["Bethesda, United States"]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Farhat","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine","place":["Bethesda, United States"]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Wassif","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine","place":["Bethesda, United States"]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter S.","family":"Backlund","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine","place":["Bethesda, United States"]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Bianconi","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine","place":["Bethesda, United States"]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karel","family":"Pacak","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine","place":["Bethesda, United States"]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethany A.","family":"Freel","sequence":"additional","affiliation":[{"name":"Cellular Therapies and Stem Cell Biology Group","place":["Sioux Falls, United States"]},{"name":"Sanford Research","place":["Sioux Falls, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3636-7264","authenticated-orcid":true,"given":"Kevin R.","family":"Francis","sequence":"additional","affiliation":[{"name":"Cellular Therapies and Stem Cell Biology Group","place":["Sioux Falls, United States"]},{"name":"Sanford Research","place":["Sioux Falls, United States"]},{"name":"Department of Pediatrics, Sanford School of Medicine","place":["Sioux Falls, United States"]},{"name":"University of South Dakota","place":["Sioux Falls, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Forbes D.","family":"Porter","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine","place":["Bethesda, United States"]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","place":["Bethesda, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3541-3361","authenticated-orcid":true,"given":"Stephanie M.","family":"Cologna","sequence":"additional","affiliation":[{"name":"Department of Chemistry","place":["Chicago, United States"]},{"name":"University of Illinois Chicago","place":["Chicago, United States"]},{"name":"Laboratory for Integrative Neuroscience","place":["Chicago, United States"]},{"name":"University of Illinois Chicago","place":["Chicago, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(64)80264-X"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320050205"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12425"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010115)98:2<191::AID-AJMG1030>3.0.CO;2-M"},{"key":"ref5\/cit5","first-page":"1","volume-title":"Genetic Syndromes","author":"Ballout R. A.","year":"2021"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1086\/301982"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.8181"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1086\/301936"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90983-n"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199401133300205"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970131)68:3<282::AID-AJMG7>3.0.CO;2-O"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.5.321"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081228"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013521.pub2"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgmr.2023.101030"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-016-9145-x"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-013-9672-5"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M014498"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37720"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-012-1925-z"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.33"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq011"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2024.108570"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049843"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.202200378"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b00254"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/25.2.256"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/32.11.2030"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.9.6.375"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1971.tb12006.x"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1126\/science.6251551"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38361"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.06.057"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021405"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010-0027"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab261"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.2c00341"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.050"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(01)00459-7"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1205516"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02906"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00043.2005"},{"issue":"2","key":"ref43\/cit43","first-page":"237","volume":"183","author":"Winkler H.","year":"1993","journal-title":"J. Anat."},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:22:1-2:63"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2011.00002"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.628859"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31347"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.102"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2004.12.009"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-0987-z"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(05)62415-4"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1007\/BF00695225"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200312000-00011"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/597395"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.039"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112669"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80782-5"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02262-7"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay7675"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2998-x"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970131)68:3<270::AID-AJMG5>3.0.CO;2-Q"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1103416"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.13735"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M113.027847"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0366-9"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106196"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02366"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.07.015"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28052166"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.07.025"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00282","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T08:13:07Z","timestamp":1754035987000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.5c00282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,9]]},"references-count":70,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,1]]}},"alternative-id":["10.1021\/acs.jproteome.5c00282"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.5c00282","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,9]]}}}