{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T18:09:25Z","timestamp":1781374165867,"version":"3.54.1"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MR\/L01341X\/1"],"award-info":[{"award-number":["MR\/L01341X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MR\/S019669\/1"],"award-info":[{"award-number":["MR\/S019669\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RE\/18\/4\/34215"],"award-info":[{"award-number":["RE\/18\/4\/34215"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004343","name":"Stavros Niarchos Foundation","doi-asserted-by":"publisher","award":["KE 14319"],"award-info":[{"award-number":["KE 14319"]}],"id":[{"id":"10.13039\/501100004343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["MC_PC_17114"],"award-info":[{"award-number":["MC_PC_17114"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023699","name":"Health Data Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2026,2,6]]},"DOI":"10.1021\/acs.jproteome.5c00459","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:53:40Z","timestamp":1769604820000},"page":"578-588","source":"Crossref","is-referenced-by-count":2,"title":["A Multiomic Approach Integrating Genomic and Metabolomic Data Highlights Colorectal Cancer Pathways"],"prefix":"10.1021","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4644-7284","authenticated-orcid":true,"given":"Aikaterini","family":"Iliou","sequence":"first","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Department of Pharmacy","place":["Athens, Greece"]},{"name":"National and Kapodistrian University of Athens","place":["Athens, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1807-2398","authenticated-orcid":true,"given":"Elena","family":"Chekmeneva","sequence":"additional","affiliation":[{"name":"National Phenome Centre, Section of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction","place":["London, U.K."]},{"name":"Imperial College London","place":["London, U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-4873","authenticated-orcid":true,"given":"Rui Climaco","family":"Pinto","sequence":"additional","affiliation":[{"name":"National Phenome Centre, Section of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction","place":["London, U.K."]},{"name":"Imperial College London","place":["London, U.K."]},{"name":"Department of Epidemiology and Biostatistics, School of Public Health","place":["London, U.K."]},{"name":"Imperial College London","place":["London, U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5675-4632","authenticated-orcid":true,"given":"Fotini E.","family":"Koukouzeli","sequence":"additional","affiliation":[{"name":"Biomedical Research Foundation of the Academy of Athens (BRFAA)","place":["Athens, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiannis","family":"Ntounias","sequence":"additional","affiliation":[{"name":"Biomedical Research Foundation of the Academy of Athens (BRFAA)","place":["Athens, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5199-5480","authenticated-orcid":true,"given":"Konstantina","family":"Georgakopoulou","sequence":"additional","affiliation":[{"name":"Biomedical Research Foundation of the Academy of Athens (BRFAA)","place":["Athens, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialena","family":"Pouliou","sequence":"additional","affiliation":[{"name":"Biomedical Research Foundation of the Academy of Athens (BRFAA)","place":["Athens, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Agelopoulos","sequence":"additional","affiliation":[{"name":"Biomedical Research Foundation of the Academy of Athens (BRFAA)","place":["Athens, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos K.","family":"Tsilidis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health","place":["London, U.K."]},{"name":"Imperial College London","place":["London, U.K."]},{"name":"Department of Hygiene and Epidemiology","place":["Ioannina, Greece"]},{"name":"University of Ioannina Medical School","place":["Ioannina, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5472-6761","authenticated-orcid":true,"given":"Marc J.","family":"Gunter","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health","place":["London, U.K."]},{"name":"Imperial College London","place":["London, U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-5684","authenticated-orcid":true,"given":"Paul","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health","place":["London, U.K."]},{"name":"Imperial College London","place":["London, U.K."]},{"name":"MRC Centre for Environment and Health, School of Public Health","place":["London, U.K."]},{"name":"Imperial College London","place":["London, U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian L.","family":"Griffin","sequence":"additional","affiliation":[{"name":"The Rowett Institute","place":["Aberdeen, U.K."]},{"name":"University of Aberdeen","place":["Aberdeen, U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Dehghan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health","place":["London, U.K."]},{"name":"Imperial College London","place":["London, U.K."]},{"name":"MRC Centre for Environment and Health, School of Public Health","place":["London, U.K."]},{"name":"Imperial College London","place":["London, U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Klinakis","sequence":"additional","affiliation":[{"name":"Biomedical Research Foundation of the Academy of Athens (BRFAA)","place":["Athens, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5984-5169","authenticated-orcid":true,"given":"Emmanuel","family":"Mikros","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Department of Pharmacy","place":["Athens, Greece"]},{"name":"National and Kapodistrian University of Athens","place":["Athens, Greece"]},{"name":"Athena Research and Innovation Center in Information Communication & Knowledge Technologies","place":["Marousi, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Tzoulaki","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health","place":["London, U.K."]},{"name":"Imperial College London","place":["London, U.K."]},{"name":"Biomedical Research Foundation of the Academy of Athens (BRFAA)","place":["Athens, Greece"]},{"name":"MRC Centre for Environment and Health, School of Public Health","place":["London, U.K."]},{"name":"Imperial College London","place":["London, U.K."]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0201-5"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09775-w"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8138"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0286-6"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgy026"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71948-1"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-13-0131"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4894-4"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10080246"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.243"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2018.01.009"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78038-2"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41216-y"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12010059"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2014.07.025"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-306705"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/ac048630x"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9868.00346"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw705"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1042\/bj20031041"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202181"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1256405"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.12245"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S272752"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)70013-N"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.048"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2006"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.011171"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0375-3"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg070"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20885-8"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00459","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T09:16:03Z","timestamp":1770369363000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.5c00459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,6]]}},"alternative-id":["10.1021\/acs.jproteome.5c00459"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.5c00459","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]}}}