{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T19:56:26Z","timestamp":1770407786466,"version":"3.49.0"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012352","name":"Universit? degli Studi di Milano","doi-asserted-by":"publisher","award":["PSR 2021-GSA-Linea 6"],"award-info":[{"award-number":["PSR 2021-GSA-Linea 6"]}],"id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2026,2,6]]},"DOI":"10.1021\/acs.jproteome.5c00653","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T08:23:42Z","timestamp":1769415822000},"page":"684-699","source":"Crossref","is-referenced-by-count":0,"title":["Proteomics-Driven Mechanistic Insights into the Anti-Inflammatory Potential of Thinned Apple Polyphenols in a DNBS-Induced Colitis Model in Mice"],"prefix":"10.1021","volume":"25","author":[{"given":"Giulio","family":"Ferrario","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences (DISFARM), Universit\u00e0 degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Impellizzeri","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9335-6318","authenticated-orcid":true,"given":"Giovanna","family":"Baron","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences (DISFARM), Universit\u00e0 degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences (DISFARM), Universit\u00e0 degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Gnasso","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences (DISFARM), Universit\u00e0 degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezio","family":"Bombardelli","sequence":"additional","affiliation":[{"name":"Plantex S.a.s., Galleria Unione 5, 20122 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Carini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences (DISFARM), Universit\u00e0 degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"di Paola","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Messina, Viale SS Annunziata, 98168 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Aldini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences (DISFARM), Universit\u00e0 degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9906-6098","authenticated-orcid":true,"given":"Alessandra","family":"Altomare","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences (DISFARM), Universit\u00e0 degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000002107"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221138160"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1424606"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12731"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2024.06.049"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutos.2024.09.004"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s13659-024-00463-x"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/ph16081150"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.02.017"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201501017"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2008.01953.x"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28031356"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030834"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.06.029"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.11.012"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-70310-z"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081577"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102981"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004994"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.161653"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0172-4"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-022-00695-x"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000034"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071226"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/ijms141019891"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224095"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.09.023"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1006629"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3390\/ph12040144"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14235896"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-009-0077-z"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2015.01.003"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2011.585658"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5698931"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101440"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs300"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00653","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T09:19:23Z","timestamp":1770369563000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.5c00653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,6]]}},"alternative-id":["10.1021\/acs.jproteome.5c00653"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.5c00653","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]}}}