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The 3-year follow-up included 216 patients subjected to coronary angiography. Gensini score was used to quantify coronary atherosclerosis, and peripheral atherosclerosis was assessed by B-mode ultrasound. Serum proteins were profiled using an Explorer antibody microarray (Full Moon Biosystems, USA). In-house ELISA or commercial ELISA kits were used to validate the microarray data in the total cohort for the top five proteins from the atherosclerotic profile. Only ICAD (DNA fragmentation factor subunit, DFF45\/ICAD) was linked to type 2 diabetes and the presence of coronary artery stenosis regardless of the severity of stenosis. CD53 was also associated with coronary stenosis. IL-6 was associated with diabetes, and GSTmu (glutathione S-transferase Mu3) was associated with brachiocephalic stenosis \u2265 60% and with femoral and coronary arterial lesions. Only GRM1 (glutamate metabotropic receptor 1) showed inverse associations with coronary stenosis and cardiovascular outcomes (r = \u22120.24 and P = 0.025 and r = \u22120.31 and P = 0.007, respectively). Moreover, GRM1 was inversely associated with femoral lesions \u2265 30%. Thus, we identified previously unreported associations of the ICAD, CD53, GRM1, and GSTmu proteins with atherosclerosis, diabetes, and nonfatal cardiovascular outcomes.<\/jats:p>","DOI":"10.1021\/acs.jproteome.5c00843","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:02:03Z","timestamp":1790024523000},"page":"5039-5048","source":"Crossref","is-referenced-by-count":0,"title":["Novel Relationships\nbetween the ICAD, CD53, GRM1,\nand GSTmu Protein Levels and Atherosclerosis and Cardiovascular Outcomes"],"prefix":"10.1021","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-3538","authenticated-orcid":true,"given":"Nadezhda G.","family":"Gumanova","sequence":"first","affiliation":[{"name":"National Research Center for Preventive Medicine (NRCPM) , , Petroverigsky 10, building 3 , ,","place":["Moscow, Russian Federation, 101990"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Mols","sequence":"additional","affiliation":[{"name":"National Research Center for Preventive Medicine (NRCPM) , , Petroverigsky 10, building 3 , ,","place":["Moscow, Russian Federation, 101990"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna R.","family":"Levshina","sequence":"additional","affiliation":[{"name":"National Research Center for Preventive Medicine (NRCPM) , , Petroverigsky 10, building 3 , ,","place":["Moscow, Russian Federation, 101990"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Khadorich","sequence":"additional","affiliation":[{"name":"National Research Center for Preventive Medicine (NRCPM) , , Petroverigsky 10, building 3 , ,","place":["Moscow, Russian Federation, 101990"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena S.","family":"Luboyatnikova","sequence":"additional","affiliation":[{"name":"National Research Center for Preventive Medicine (NRCPM) , , Petroverigsky 10, building 3 , ,","place":["Moscow, Russian Federation, 101990"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artem S.","family":"Shanoyan","sequence":"additional","affiliation":[{"name":"National Research Center for Preventive Medicine (NRCPM) , , Petroverigsky 10, building 3 , ,","place":["Moscow, Russian Federation, 101990"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya L.","family":"Bogdanova","sequence":"additional","affiliation":[{"name":"National Research Center for Preventive Medicine (NRCPM) , , Petroverigsky 10, building 3 , ,","place":["Moscow, Russian Federation, 101990"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry K.","family":"Vasilyev","sequence":"additional","affiliation":[{"name":"National Research Center for Preventive Medicine (NRCPM) , , Petroverigsky 10, building 3 , ,","place":["Moscow, Russian Federation, 101990"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton R.","family":"Kiselev","sequence":"additional","affiliation":[{"name":"National Research Center for Preventive Medicine (NRCPM) , , Petroverigsky 10, building 3 , ,","place":["Moscow, Russian Federation, 101990"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"issue":"4","key":"2026100208412518200_cit1","first-page":"417","article-title":"Nikolai\nN. 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Pharmacol."},{"issue":"2","key":"2026100208412518200_cit36","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3390\/antiox13020149","article-title":"Oxidative\nStress Plays an Important Role in Glutamatergic Excitotoxicity-Induced\nCochlear Synaptopathy: Implication for Therapeutic Molecules Screening","volume":"13","author":"Saidia","year":"2024","journal-title":"Antioxidants"},{"key":"2026100208412518200_cit37","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/978-3-7091-6301-6_27","article-title":"Glutamate excitotoxicity\u2013a\nmechanism for axonal damage and oligodendrocyte death in Multiple\nSclerosis?","volume":"60","author":"Werner","year":"2000","journal-title":"J. Neural Transm. 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Res."},{"issue":"4","key":"2026100208412518200_cit45","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/mutage\/geq014","article-title":"Genetic polymorphisms\nof glutathione\nS-transferase genes GSTM1, GSTT1 and risk of coronary heart disease","volume":"25","author":"Wang","year":"2010","journal-title":"Mutagenesis"},{"issue":"9","key":"2026100208412518200_cit46","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1038\/cdd.2010.80","article-title":"Glutathione\ntransferases as mediators of signaling pathways involved in cell proliferation\nand cell death","volume":"17","author":"Laborde","year":"2010","journal-title":"Cell Death Differ."},{"issue":"6121","key":"2026100208412518200_cit47","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase\nis a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00843","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/10\/5039\/68587700\/acs.jproteome.5c00843.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/10\/5039\/68587700\/acs.jproteome.5c00843.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:51:39Z","timestamp":1790945499000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jprobs\/article\/25\/10\/5039\/5434719\/Novel-Relationships-between-the-ICAD-CD53-GRM1-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":47,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,21]]},"published-print":{"date-parts":[[2026,10,2]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.5c00843","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]}}}