{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:16:12Z","timestamp":1786122972013,"version":"build-2736575974"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000165","name":"Division of Chemistry","doi-asserted-by":"publisher","award":["2305137"],"award-info":[{"award-number":["2305137"]}],"id":[{"id":"10.13039\/100000165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM103440"],"award-info":[{"award-number":["GM103440"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Huntington\u2019s Disease (HD), a neurodegenerative disorder, is caused by the expansion of a polyglutamine (polyQ) tract near the N-terminus of the huntingtin protein (HTT), resulting in HTT aggregation. While associated with neurodegeneration, HTT is expressed ubiquitously throughout the body, leading to potential peripheral consequences of aggregation. However, the impact on peripheral tissues remains poorly understood in comparison to the central nervous system. Here, a Caenorhabditis elegans (C. elegans) HD model that expresses an N-terminal HTT fragment (nonpathogenic 15Q or pathogenic 128Q) in body-wall muscle cells was used to evaluate proteome remodeling. Four conditions (15Q and 128Q on days 2 and 7 of adult worms, denoted as 15D2, 15D7, 128D2, and 128D7) were evaluated. In comparison to 15D2, 128D2 worms displayed decreased expression of ribosomal proteins and cytoskeletal components such as actin, profilin, calponin, and myosin, as well as overexpression of galectin, a stress- and inflammation-associated protein. By day 7, the 15D7 animals exhibited developmental signatures related to ribosome biogenesis, signal transduction, and vesicle trafficking, whereas abundance levels of proteins associated with stress response pathways such as proteostasis, protein folding, and cytoskeletal remodeling were observed to be increased in the 128D7 worms. These findings demonstrate the stage-dependent, nonlinear nature of HD-associated proteome disruption associated with peripheral expression of HD.<\/jats:p>","DOI":"10.1021\/acs.jproteome.5c00850","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:15:35Z","timestamp":1782749735000},"page":"3845-3860","source":"Crossref","is-referenced-by-count":0,"title":["Proteomic\nImpact of Peripheral Expression of Mutant\nHuntingtin in\n                    <i>C. elegans<\/i>"],"prefix":"10.1021","volume":"25","author":[{"given":"Ephraim","family":"Ezeigbo","sequence":"first","affiliation":[{"name":"West Virginia University , , 217 Clark Hall , , ,","place":["Morgantown, West Virginia, United States, 26506"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa","family":"Stonebraker","sequence":"additional","affiliation":[{"name":"West Virginia University , , 217 Clark Hall , , ,","place":["Morgantown, West Virginia, United States, 26506"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5067-8509","authenticated-orcid":true,"given":"Herbi","family":"Yuliantoro","sequence":"additional","affiliation":[{"name":"West Virginia University , , 217 Clark Hall , , ,","place":["Morgantown, West Virginia, United States, 26506"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjola","family":"Adewoye","sequence":"additional","affiliation":[{"name":"West Virginia University , , 217 Clark Hall , , ,","place":["Morgantown, West Virginia, United States, 26506"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Debastiani","sequence":"additional","affiliation":[{"name":"West Virginia University , , 217 Clark Hall , , ,","place":["Morgantown, West Virginia, United States, 26506"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Roefer","sequence":"additional","affiliation":[{"name":"University of Nevada , , 1664 N. Virginia Street , , ,","place":["Reno, Nevada, United States, 89557"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritom Kumar","family":"Biswas","sequence":"additional","affiliation":[{"name":"University of Nevada , , 1664 N. Virginia Street , , ,","place":["Reno, Nevada, United States, 89557"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"West Virginia University , , 217 Clark Hall , , ,","place":["Morgantown, West Virginia, United States, 26506"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-1867","authenticated-orcid":true,"given":"Justin","family":"Legleiter","sequence":"additional","affiliation":[{"name":"University of Nevada , , 1664 N. Virginia Street , , ,","place":["Reno, Nevada, United States, 89557"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4360-2928","authenticated-orcid":true,"given":"Stephen J.","family":"Valentine","sequence":"additional","affiliation":[{"name":"University of Louisvile , , 2301 S third St , , ,","place":["Louisville, Kentucky, United States, 40208"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"2026080709083553400_cit1","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/B978-0-12-381328-2.00014-6","article-title":"Genetics and Neuropathology\nof Huntington\u2019s Disease","volume-title":"International\nReview of Neurobiology","author":"Reiner","year":"2011"},{"key":"2026080709083553400_cit2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/B978-0-12-381328-2.00013-4","article-title":"Huntington\u2019s\nDisease: Clinical Presentation and Treatment","volume-title":"International Review of Neurobiology","author":"Novak","year":"2011"},{"issue":"1","key":"2026080709083553400_cit3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington\u2019s\nDisease: A Clinical Review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur. J. Neurol."},{"issue":"1","key":"2026080709083553400_cit4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1177\/18796397251319209","article-title":"Economic Burden\nof Huntington\u2019s Disease: A Systematic\nReview","volume":"14","author":"Gokhale","year":"2025","journal-title":"J. Huntingt. Dis."},{"issue":"6","key":"2026080709083553400_cit5","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A Novel Gene\nContaining a Trinucleotide Repeat That Is Expanded and Unstable on\nHuntington\u2019s Disease Chromosomes","volume":"72","author":"Macdonald","year":"1993","journal-title":"Cell"},{"issue":"4","key":"2026080709083553400_cit6","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/s41593-022-01033-5","article-title":"Exome Sequencing of Individuals with Huntington\u2019s\nDisease Implicates FAN1 Nuclease Activity in Slowing CAG Expansion\nand Disease Onset","volume":"25","author":"McAllister","year":"2022","journal-title":"Nat. Neurosci."},{"issue":"18","key":"2026080709083553400_cit7","doi-asserted-by":"publisher","first-page":"3044","DOI":"10.1093\/hmg\/ddaa196","article-title":"Promotion\nof Somatic CAG Repeat Expansion by Fan1 Knock-out in Huntington\u2019s\nDisease Knock-in Mice Is Blocked by Mlh1 Knock-Out","volume":"29","author":"Loupe","year":"2020","journal-title":"Hum. Mol. Genet."},{"issue":"12","key":"2026080709083553400_cit8","doi-asserted-by":"publisher","first-page":"4119","DOI":"10.1080\/15548627.2021.1904489","article-title":"Modulating\nFKBP5\/FKBP51 and Autophagy Lowers HTT (Huntingtin)\nLevels","volume":"17","author":"Bailus","year":"2021","journal-title":"Autophagy"},{"issue":"5","key":"2026080709083553400_cit9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030082","article-title":"Huntingtin\nInteracting Proteins Are Genetic Modifiers of Neurodegeneration","volume":"3","author":"Kaltenbach","year":"2007","journal-title":"PLoS Genet."},{"key":"2026080709083553400_cit10","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa066","article-title":"Subcellular Localisation and Formation\nof Huntingtin\nAggregates Correlates with Symptom Onset and Progression in a Huntington\u2019s\nDisease Model","author":"Landles","year":"2020","journal-title":"Brain Commun."},{"issue":"31","key":"2026080709083553400_cit11","doi-asserted-by":"publisher","first-page":"19287","DOI":"10.1074\/jbc.M114.623561","article-title":"Integration-Independent\nTransgenic Huntington Disease\nFragment Mouse Models Reveal Distinct Phenotypes and Life Span in\nVivo","volume":"290","author":"O\u2019Brien","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"1","key":"2026080709083553400_cit12","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s40478-021-01172-z","article-title":"Correlative\nLight and Electron Microscopy\nSuggests That Mutant Huntingtin Dysregulates the Endolysosomal Pathway\nin Presymptomatic Huntington\u2019s Disease","volume":"9","author":"Zhou","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"2026080709083553400_cit13","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1038\/s41467-021-21637-y","article-title":"Mutant Huntingtin\nStalls Ribosomes and Represses Protein\nSynthesis in a Cellular Model of Huntington Disease","volume":"12","author":"Eshraghi","year":"2021","journal-title":"Nat. Commun."},{"key":"2026080709083553400_cit14","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.mcn.2017.12.005","article-title":"Aberrant Subcellular\nLocalization of SQSTM1\/P62 Contributes to Increased Vulnerability\nto Proteotoxic Stress Recovery in Huntington\u2019s Disease","volume":"88","author":"Huang","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"issue":"12","key":"2026080709083553400_cit15","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1002\/jnr.24505","article-title":"Circadian\nDysfunction\nin the Q175 Model of Huntington\u2019s Disease: Network Analysis","volume":"97","author":"Smarr","year":"2019","journal-title":"J. Neurosci. Res."},{"issue":"8","key":"2026080709083553400_cit16","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/S1474-4422(09)70178-4","article-title":"Beyond the Brain: Widespread\nPathology in Huntington\u2019s Disease","volume":"8","author":"Van Der Burg","year":"2009","journal-title":"Lancet\nNeurol."},{"issue":"2","key":"2026080709083553400_cit17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3233\/JHD-200465","article-title":"Taming the Huntington\u2019s Disease\nProteome: What\nHave We Learned?","volume":"10","author":"Seeley","year":"2021","journal-title":"J. Huntingt. Dis."},{"issue":"5","key":"2026080709083553400_cit18","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1074\/mcp.M200016-MCP200","article-title":"Alterations\nin the Mouse and Human\nProteome Caused by Huntington\u2019s Disease","volume":"1","author":"Zabel","year":"2002","journal-title":"Mol. Cell. Proteomics"},{"issue":"2","key":"2026080709083553400_cit19","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1093\/toxsci\/kft199","article-title":"Oxidizing\nEffects of Exogenous Stressors in Huntington\u2019s Disease Knock-in\nStriatal Cells\u2500Protective Effect of Cystamine and Creatine","volume":"136","author":"Ribeiro","year":"2013","journal-title":"Toxicol. Sci."},{"issue":"5667","key":"2026080709083553400_cit20","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1126\/science.1092194","article-title":"SUMO Modification of Huntingtin and\nHuntington\u2019s\nDisease Pathology","volume":"304","author":"Steffan","year":"2004","journal-title":"Science"},{"issue":"3","key":"2026080709083553400_cit21","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3233\/JHD-220538","article-title":"Mutant Huntingtin\nProtein Interaction Map Implicates Dysregulation\nof Multiple Cellular Pathways in Neurodegeneration of Huntington\u2019s\nDisease","volume":"11","author":"Podvin","year":"2022","journal-title":"J. Huntingt. Dis."},{"issue":"4","key":"2026080709083553400_cit22","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nn.4256","article-title":"Integrated\nGenomics and Proteomics Define Huntingtin\nCAG Length\u2013Dependent Networks in Mice","volume":"19","author":"Langfelder","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"5","key":"2026080709083553400_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2023.100534","article-title":"Proteomic Analysis\nof Huntington\u2019s Disease Medium Spiny Neurons Identifies Alterations\nin Lipid Droplets","volume":"22","author":"Tshilenge","year":"2023","journal-title":"Mol. Cell. Proteomics"},{"issue":"1","key":"2026080709083553400_cit24","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3390\/brainsci15010076","article-title":"A Pilot Proteomic Analysis of Huntington\u2019s Disease\nby Functional Capacity","volume":"15","author":"McGarry","year":"2025","journal-title":"Brain Sci."},{"issue":"8","key":"2026080709083553400_cit25","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1016\/j.celrep.2017.10.097","article-title":"Spatiotemporal\nProteomic Profiling\nof Huntington\u2019s Disease Inclusions Reveals Widespread Loss\nof Protein Function","volume":"21","author":"Hosp","year":"2017","journal-title":"Cell Rep."},{"issue":"3","key":"2026080709083553400_cit26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173644","article-title":"A New Caenorhabditis\nElegans Model of Human Huntingtin 513 Aggregation and Toxicity in\nBody Wall Muscles","volume":"12","author":"Lee","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"2026080709083553400_cit27","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1534\/genetics.115.176099","article-title":"A Transparent\nWindow into Biology:\nA Primer on Caenorhabditis Elegans","volume":"200","author":"Corsi","year":"2015","journal-title":"Genetics"},{"key":"2026080709083553400_cit28","doi-asserted-by":"publisher","first-page":"52321","DOI":"10.3791\/52321","article-title":"Investigating\nthe Spreading and Toxicity of Prion-like Proteins Using the Metazoan\nModel Organism C. Elegans","volume":"95","author":"Nussbaum-Krammer","year":"2015","journal-title":"J. Vis. Exp."},{"issue":"7","key":"2026080709083553400_cit29","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An Open-Source\nPlatform for Biological-Image Analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat.\nMethods"},{"issue":"D1","key":"2026080709083553400_cit30","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING\nDatabase in 2021: Customizable Protein\u2013Protein Networks, and\nFunctional Characterization of User-Uploaded Gene\/Measurement Sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"2026080709083553400_cit31","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1074\/mcp.M500061-MCP200","article-title":"Exponentially Modified Protein Abundance Index (emPAI) for Estimation\nof Absolute Protein Amount in Proteomics by the Number of Sequenced\nPeptides per Protein","volume":"4","author":"Ishihama","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"issue":"3","key":"2026080709083553400_cit32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032339","article-title":"The Optimal\nExponent Base for emPAI Is 6.5","volume":"7","author":"Kudlicki","year":"2012","journal-title":"PLoS One"},{"key":"2026080709083553400_cit33","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/978-1-4939-0685-7_14","article-title":"Spectral Counting Label-Free Proteomics","year":"2014","journal-title":"Methods in Molecular Biology"},{"key":"2026080709083553400_cit34","doi-asserted-by":"publisher","first-page":"5710","DOI":"10.1021\/acs.jproteome.5c00414","article-title":"New Method of Enhanced\nExtraction of Protein Signatures of Renal Cell Carcinoma from Proteomics\nData","volume":"24","author":"Liu","year":"2025","journal-title":"J. Proteome Res."},{"key":"2026080709083553400_cit35","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.1021\/acs.jproteome.4c00783","article-title":"Data-Independent Acquisition-Based\nQuantitative Proteomics for Pairwise Comparison of Serum and Plasma","volume":"24","author":"Li","year":"2025","journal-title":"J. Proteome Res."},{"key":"2026080709083553400_cit36","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1021\/acs.jproteome.7b00487","article-title":"Identification of\nMature Atherosclerotic\nPlaque Proteome Signatures Using Data-Independent Acquisition Mass\nSpectrometry","volume":"17","author":"Hansmeier","year":"2018","journal-title":"J. Proteome Res."},{"key":"2026080709083553400_cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.117827","article-title":"The Role of Mitochondrial\nDysfunction in Huntington\u2019s\nDisease: Implications for Therapeutic Targeting","volume":"183","author":"Joshi","year":"2025","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"2026080709083553400_cit38","doi-asserted-by":"publisher","first-page":"4269","DOI":"10.18632\/aging.101721","article-title":"Protein Synthesis and Quality Control in Aging","volume":"10","author":"Anisimova","year":"2018","journal-title":"Aging"},{"key":"2026080709083553400_cit39","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.98363","article-title":"Pathogenic Huntingtin Aggregates Alter Actin Organization\nand Cellular Stiffness Resulting in Stalled Clathrin-Mediated Endocytosis","volume":"13","author":"Singh","year":"2024","journal-title":"eLife"},{"issue":"10","key":"2026080709083553400_cit40","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.1074\/jbc.RA117.000357","article-title":"Profilin Reduces Aggregation and\nPhase Separation of Huntingtin N-Terminal Fragments by Preferentially\nBinding to Soluble Monomers and Oligomers","volume":"293","author":"Posey","year":"2018","journal-title":"J.\nBiol. Chem."},{"issue":"11","key":"2026080709083553400_cit41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166106","article-title":"Fast-to-Slow Transition of Skeletal\nMuscle Contractile\nFunction and Corresponding Changes in Myosin Heavy and Light Chain\nFormation in the R6\/2 Mouse Model of Huntington\u2019s Disease","volume":"11","author":"Hering","year":"2016","journal-title":"PLoS One"},{"key":"2026080709083553400_cit42","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.854321","article-title":"Mitochondrial\nATP Synthase Is a Target of Oxidative\nStress in Neurodegenerative Diseases","volume":"9","author":"Ebanks","year":"2022","journal-title":"Front.\nMol. Biosci."},{"issue":"4","key":"2026080709083553400_cit43","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.bbrc.2009.10.139","article-title":"Overexpression of\nF0F1-ATP Synthase \u03b1 Suppresses Mutant Huntingtin Aggregation\nand Toxicity in Vitro","volume":"390","author":"Wang","year":"2009","journal-title":"Biochem. Biophys. Res.\nCommun."},{"issue":"3","key":"2026080709083553400_cit44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000334","article-title":"Mechanisms of Copper\nIon Mediated Huntington\u2019s\nDisease Progression","volume":"2","author":"Fox","year":"2007","journal-title":"PLoS One"},{"issue":"1","key":"2026080709083553400_cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166928","article-title":"Copper Enhances\nAggregational Toxicity of Mutant Huntingtin\nin a Drosophila Model of Huntington\u2019s Disease","volume":"1870","author":"Lobato","year":"2024","journal-title":"Biochim. Biophys. Acta BBA - Mol. Basis Dis."},{"issue":"8","key":"2026080709083553400_cit46","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1212\/WNL.40.8.1231","article-title":"Evidence for a Defect\nin NADH: Ubiquinone Oxidoreductase (Complex I) in Huntington\u2019s\nDisease","volume":"40","author":"Parker","year":"1990","journal-title":"Neurology"},{"issue":"23","key":"2026080709083553400_cit47","doi-asserted-by":"publisher","first-page":"3806","DOI":"10.1002\/1873-3468.13082","article-title":"The Role of\nHeparan Sulfates in Protein Aggregation and Their Potential Impact\non Neurodegeneration","volume":"592","author":"Mai\u0308za","year":"2018","journal-title":"FEBS Lett."},{"key":"2026080709083553400_cit48","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3389\/fnmol.2014.00077","article-title":"Ubiquitina\u0302\u20ac\u201cproteasome System\nInvolvement in Huntingtona\u0302\u20acTMs Disease","volume":"7","author":"Ortega","year":"2014","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"2026080709083553400_cit49","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1038\/s41467-018-03509-0","article-title":"A Common Mechanism of Proteasome\nImpairment by Neurodegenerative Disease-Associated Oligomers","volume":"9","author":"Thibaudeau","year":"2018","journal-title":"Nat. Commun."},{"issue":"26","key":"2026080709083553400_cit50","doi-asserted-by":"publisher","first-page":"21599","DOI":"10.1074\/jbc.M112.359307","article-title":"Proteomic\nAnalysis\nof Wild-Type and Mutant Huntingtin-Associated Proteins in Mouse Brains\nIdentifies Unique Interactions and Involvement in Protein Synthesis","volume":"287","author":"Culver","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"2","key":"2026080709083553400_cit51","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1042\/BJ20071619","article-title":"Huntington\u2019s Disease: From\nPathology and Genetics to Potential Therapies","volume":"412","author":"Imarisio","year":"2008","journal-title":"Biochem. J."},{"issue":"1","key":"2026080709083553400_cit52","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1021\/pr015504q","article-title":"DTASelect and Contrast: Tools for\nAssembling and Comparing Protein Identifications from Shotgun Proteomics","volume":"1","author":"Tabb","year":"2002","journal-title":"J. Proteome Res."},{"issue":"1","key":"2026080709083553400_cit53","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41392-022-01285-4","article-title":"Ribosome Biogenesis\nin Disease: New\nPlayers and Therapeutic Targets","volume":"8","author":"Jiao","year":"2023","journal-title":"Signal Transduct.\nTarget. 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