{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:56:23Z","timestamp":1790733383929,"version":"4.1.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1R35GM154953"],"award-info":[{"award-number":["1R35GM154953"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2026,1,2]]},"DOI":"10.1021\/acs.jproteome.5c00980","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:02:22Z","timestamp":1764676942000},"page":"471-483","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating and Optimizing Mass Spectrometry Proteomics Data to Deconvolve Cell-Type-Specific Protein Expression in Tumors"],"prefix":"10.1021","volume":"25","author":[{"given":"Yingnan","family":"Song","sequence":"first","affiliation":[{"name":"Department of Genetics","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Genetics","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2777-7365","authenticated-orcid":true,"given":"Chen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Genetics","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]},{"name":"O\u2019Neal Comprehensive Cancer Center","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.02.016"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-042020-042741"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3225"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00446-5"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2022.102736"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.14670\/HH-11-622"},{"key":"ref8\/cit8a","doi-asserted-by":"publisher","DOI":"10.1074\/mcpM115054585"},{"key":"ref8\/cit8b","doi-asserted-by":"publisher","DOI":"10.1186\/s12014-022-09373-x"},{"key":"ref8\/cit8c","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.3c00164"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.09.022"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.023"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae267"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3612"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbae234"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.06.009"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.5114\/wo.2014.47136"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1024-4_8"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1526-y"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19015-1"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.04.008"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.007"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/nature13438"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1210-1248"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.057"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3612"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1507"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.08.013"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/nargab\/lqaa110"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1439"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1101\/gr.268722.120"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae456"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2203"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1177\/001316446002000104"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2012.031"},{"key":"ref36\/cit36a","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2344"},{"key":"ref36\/cit36b","doi-asserted-by":"publisher","DOI":"10.1038\/nature16965"},{"key":"ref37\/cit37a","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.08.033"},{"key":"ref37\/cit37b","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317706"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0300-1"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3398"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(62)90042-8"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c00713"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.09.028"},{"key":"ref43\/cit43a","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.07.014"},{"key":"ref43\/cit43b","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.05.039"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/pr201185r"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00980","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c00980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:04:34Z","timestamp":1768568674000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.5c00980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,2]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,2]]}},"alternative-id":["10.1021\/acs.jproteome.5c00980"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.5c00980","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,2]]}}}