{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:44:40Z","timestamp":1784072680828,"version":"3.55.0"},"reference-count":77,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["R.12015\/01\/2022-HR"],"award-info":[{"award-number":["R.12015\/01\/2022-HR"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","award":["R.12015\/01\/2022-HR"],"award-info":[{"award-number":["R.12015\/01\/2022-HR"]}],"id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2026,3,6]]},"DOI":"10.1021\/acs.jproteome.5c01121","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:41:13Z","timestamp":1770943273000},"page":"1724-1736","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive Serum Proteomics Uncovers Epigenetic and Inflammatory Pathways Underlying Primary Open-Angle Glaucoma"],"prefix":"10.1021","volume":"25","author":[{"given":"Vinayak","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Medical Devices, NIPER, SAS Nagar, Mohali, Punjab 160062, India"},{"name":"Department of Biophysics","place":["Chandigarh, India"]},{"name":"PGIMER","place":["Chandigarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ojas","family":"Tikoo","sequence":"additional","affiliation":[{"name":"Department of Biophysics","place":["Chandigarh, India"]},{"name":"PGIMER","place":["Chandigarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Bhagat","sequence":"additional","affiliation":[{"name":"Department of Biophysics","place":["Chandigarh, India"]},{"name":"PGIMER","place":["Chandigarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag","family":"Gala","sequence":"additional","affiliation":[{"name":"Department of Medical Devices, NIPER, SAS Nagar, Mohali, Punjab 160062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit Kumar","family":"Nadda","sequence":"additional","affiliation":[{"name":"Department of Hepatology","place":["Chandigarh, India"]},{"name":"PGIMER","place":["Chandigarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Advance Eye Centre","place":["Chandigarh, India"]},{"name":"PGIMER","place":["Chandigarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Thattaruthody","sequence":"additional","affiliation":[{"name":"Advance Eye Centre","place":["Chandigarh, India"]},{"name":"PGIMER","place":["Chandigarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipun","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Hepatology","place":["Chandigarh, India"]},{"name":"PGIMER","place":["Chandigarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalmoli","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Biophysics","place":["Chandigarh, India"]},{"name":"PGIMER","place":["Chandigarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surinder Singh","family":"Pandav","sequence":"additional","affiliation":[{"name":"Advance Eye Centre","place":["Chandigarh, India"]},{"name":"PGIMER","place":["Chandigarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3412-1823","authenticated-orcid":true,"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medical Devices, NIPER, SAS Nagar, Mohali, Punjab 160062, India"},{"name":"Department of Biophysics","place":["Chandigarh, India"]},{"name":"PGIMER","place":["Chandigarh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-016-0220-6"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108506"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2019.103483"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14938-0"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2011.01.001"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000000106"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03345-1"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-14800"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26346-0"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201500423"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.8b00244"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-017-0791-0"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0324806"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-018-0885-3"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2174\/1874609811104020110"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-018-0723-4"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12858-7"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2007.08.010"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2005.11.001"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2017.05.004"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5269"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2017.1327605"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2005.04.004"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-23434"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.020024"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01284.x"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.5.899"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5300.668"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1039\/C1MB05357D"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0693"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000002341"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1080\/13816810.2018.1432061"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.14.4"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16008"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153354"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9171536"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101070"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1151185"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081239"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8152"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/812503"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2013.07.017"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2018.3623"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2007.02.001"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-013-0837-3"},{"key":"ref47\/cit47","first-page":"1667","volume":"19","author":"Kim H. S.","year":"2013","journal-title":"Mol. Vis"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12157"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9259"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2015.1050736"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-020-0657-6"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-13-74"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp307"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt614"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146915"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi.20-00002"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.3390\/biology11010090"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01024"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.8.e101"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2016.08.002"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.4161\/auto.23458"},{"key":"ref62\/cit62","doi-asserted-by":"crossref","unstructured":"Tanihara, H.; Inatani, M.; Koga, T.; Yano, T.; Kimura, A.\n                      Proteoglycans in the Eye\n                      ; Lippincott Williams & Wilkins: Inc, Philadelphia, 2002; Vol. 21, pp S62\u2013S69.","DOI":"10.1097\/01.ico.0000263121.45898.d2"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-0736"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24826"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1159\/000089523"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1016\/s0041-1345(97)00564-2"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.80.6.1681"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/pr1005372"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05273-0"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69071"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1313769110"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-017-0005-3"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703707104"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4081-y"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205160"},{"key":"ref76\/cit76","first-page":"473","volume-title":"Brain Res. Bull","volume":"62","author":"Tezel G.","year":"2004"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00381"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c01121","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.5c01121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:32:51Z","timestamp":1773214371000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.5c01121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,6]]}},"alternative-id":["10.1021\/acs.jproteome.5c01121"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.5c01121","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]}}}