{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:28:28Z","timestamp":1788532108205,"version":"build-2803163510"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Science and Technology Plan of Guilin"},{"name":"Guangdong Provincial Autoimmune Disease Precision Medicine Engineering Research Center"},{"name":"Shenzhen Autoimmune Disease Engineering Research Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Delayed graft function (DGF) is a common early complication of kidney transplantation characterized by immune activation. The duration of DGF may significantly affect long-term graft survival, yet the immune mechanisms underlying the different DGF durations remain unclear. Using a functional definition of delayed graft function (fDGF), defined as a failure of serum creatinine to decrease by at least 10% per day for three consecutive days within the first postoperative week, patients were stratified into short-term DGF (SDGF) and long-term DGF (LDGF) groups according to recovery periods. In this exploratory study, targeted proteomic analysis indicated that proteins enriched in SDGF were primarily involved in innate immune responses and acute inflammatory processes, including neutrophil chemotaxis and migration, whereas LDGF exhibited features related to adaptive immune responses and chronic inflammation, such as T-cell differentiation and activation. IL-7 and CCL20 were identified as candidate molecules potentially associated with different DGF durations. Targeted metabolomics revealed disturbances in amino acid metabolism, particularly alanine, aspartate, and glutamate metabolism, as well as in energy metabolism, including the tricarboxylic acid (TCA) cycle, which may be involved in LDGF. These findings provide preliminary insights into immune metabolic features associated with different DGF recovery durations.<\/jats:p>","DOI":"10.1021\/acs.jproteome.5c01139","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T16:01:39Z","timestamp":1786896099000},"page":"4496-4510","source":"Crossref","is-referenced-by-count":0,"title":["Immune Regulatory\nSignatures Associated with Different\nRecovery Durations of Delayed Graft Function after Kidney Transplantation"],"prefix":"10.1021","volume":"25","author":[{"given":"Yaxin","family":"Zheng","sequence":"first","affiliation":[{"name":"The 924th Hospital of the Chinese People\u2019s Liberation Army Joint Logistic Support Force , , , ,","place":["Guilin, Guangxi, China, 541002"]},{"name":"Guangxi Normal University , , , ,","place":["Guilin, Guangxi, China, 541006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-9158","authenticated-orcid":true,"given":"Yong","family":"Dai","sequence":"additional","affiliation":[{"name":"The 924th Hospital of the Chinese People\u2019s Liberation Army Joint Logistic Support Force , , , ,","place":["Guilin, Guangxi, China, 541002"]},{"name":"Southern University of Science and Technology, The Second ClinicalMedical College, Jinan University) , , , ,","place":["Shenzhen, Guangdong, China, 518020"]},{"name":"Anhui University of Science & Technology , , , ,","place":["Huainan, Anhui, China, 232001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengying","family":"Zhou","sequence":"additional","affiliation":[{"name":"The 924th Hospital of the Chinese People\u2019s Liberation Army Joint Logistic Support Force , , , ,","place":["Guilin, Guangxi, China, 541002"]},{"name":"Guangxi Normal University , , , ,","place":["Guilin, Guangxi, China, 541006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyu","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangxi Normal University , , , ,","place":["Guilin, Guangxi, China, 541006"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyao","family":"Wang","sequence":"additional","affiliation":[{"name":"The 924th Hospital of the Chinese People\u2019s Liberation Army Joint Logistic Support Force , , , ,","place":["Guilin, Guangxi, China, 541002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liusheng","family":"Lai","sequence":"additional","affiliation":[{"name":"The 924th Hospital of the Chinese People\u2019s Liberation Army Joint Logistic Support Force , , , ,","place":["Guilin, Guangxi, China, 541002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Liao","sequence":"additional","affiliation":[{"name":"The 924th Hospital of the Chinese People\u2019s Liberation Army Joint Logistic 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541002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengying","family":"Wang","sequence":"additional","affiliation":[{"name":"The 924th Hospital of the Chinese People\u2019s Liberation Army Joint Logistic Support Force , , , ,","place":["Guilin, Guangxi, China, 541002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaizhou","family":"Chen","sequence":"additional","affiliation":[{"name":"The 924th Hospital of the Chinese People\u2019s Liberation Army Joint Logistic Support Force , , , ,","place":["Guilin, Guangxi, China, 541002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-196X","authenticated-orcid":true,"given":"Donge","family":"Tang","sequence":"additional","affiliation":[{"name":"The 924th Hospital of the Chinese People\u2019s Liberation Army Joint Logistic Support Force , , , ,","place":["Guilin, Guangxi, China, 541002"]},{"name":"Guangxi Normal University , , , ,","place":["Guilin, Guangxi, China, 541006"]},{"name":"Southern University of Science and Technology, The Second ClinicalMedical College, Jinan University) , , , ,","place":["Shenzhen, Guangdong, China, 518020"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3527-7868","authenticated-orcid":true,"given":"Qiang","family":"Yan","sequence":"additional","affiliation":[{"name":"The 924th Hospital of the Chinese People\u2019s Liberation Army Joint Logistic Support Force , , , ,","place":["Guilin, Guangxi, China, 541002"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,16]]},"reference":[{"issue":"5","key":"2026090409135163700_cit1","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1097\/CM9.0000000000000666","article-title":"Delayed graft function is correlated with graft loss\nin recipients of expanded-criteria rather than standard-criteria donor\nkidneys: a retrospective, multicenter, 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Biochem."},{"key":"2026090409135163700_cit26","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12111125","article-title":"Identification of\nserum metabolites for predicting chronic kidney disease progression\naccording to chronic kidney disease cause","volume":"12","author":"Kang","year":"2022","journal-title":"Metabolites"},{"key":"2026090409135163700_cit27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144188","article-title":"Prolonged delayed graft function\nis associated with inferior patient and kidney allograft survivals","volume":"10","author":"de Sandes-Freitas","year":"2015","journal-title":"PLoS One"},{"key":"2026090409135163700_cit28","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1093\/ndt\/gfab304","article-title":"Evaluation\nof severity of delayed graft function in kidney transplant recipients","volume":"37","author":"Schrezenmeier","year":"2022","journal-title":"Nephrol. Dial. 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