{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:53:50Z","timestamp":1790679230302,"version":"4.1.0"},"reference-count":93,"publisher":"American Chemical Society (ACS)","issue":"10","funder":[{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000317","name":"Action Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000601","name":"De Montfort University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001320","name":"Wolfson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000861","name":"Sparks","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000861","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Niemann-Pick Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2016,10,7]]},"DOI":"10.1021\/acs.jproteome.6b00238","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T09:54:47Z","timestamp":1470736487000},"page":"3511-3527","source":"Crossref","is-referenced-by-count":20,"title":["<sup>1<\/sup>H NMR-Linked Metabolomics Analysis of Liver from a Mouse Model of NP-C1 Disease"],"prefix":"10.1021","volume":"15","author":[{"given":"Victor","family":"Ruiz-Rodado","sequence":"first","affiliation":[{"name":"Leicester\rSchool of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena-Raluca","family":"Nicoli","sequence":"additional","affiliation":[{"name":"Department\rof Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fay","family":"Probert","sequence":"additional","affiliation":[{"name":"Leicester\rSchool of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department\rof Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Morris","sequence":"additional","affiliation":[{"name":"Department\rof Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Wassif","sequence":"additional","affiliation":[{"name":"Department\rof Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom"},{"name":"Eunice\rKennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.","family":"Platt","sequence":"additional","affiliation":[{"name":"Department\rof Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Grootveld","sequence":"additional","affiliation":[{"name":"Leicester\rSchool of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-16"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2009.06.008"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2003.00147.x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1086\/320599"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R047837"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81695-6"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R100057200"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20868"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22327"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810895106"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.2174\/2213235X03666141219203205"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.07.009"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.2174\/2213235X01666131203230512"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.2174\/2213235X02666141112215616"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082685"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds193"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/pr901203w"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5323.232"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00345-5"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1016\/S0021-9258(18)91082-3","volume":"259","author":"Pentchev P. G.","year":"1984","journal-title":"J. Biol. Chem."},{"key":"ref21\/cit21","first-page":"140","volume":"108","author":"Morris M. D.","year":"1982","journal-title":"Am. J. Pathol."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311591200"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/tx010067f"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066786"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1065"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti476"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv380"},{"key":"ref28\/cit28","first-page":"18","volume":"2","author":"Liaw A.","year":"2002","journal-title":"R News"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-4-S1-S64"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-012-0482-9"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbl022"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.10.007"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/tx049869b"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M007211"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800415-JLR200"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00429-4"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.12.008"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i44.6926"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.19.2.317"},{"key":"ref41\/cit41","first-page":"2261","volume":"45","author":"Toyoki Y.","year":"1998","journal-title":"Hepatogastroenterology"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2010.563"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1080\/03601238809372615"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4908(80)80030-5"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.526392"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M007211"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad9407"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M040618"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(95)03177-H"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"1539S","DOI":"10.1093\/jn\/137.6.1539S","volume":"137","author":"Fernstrom J. D.","year":"2007","journal-title":"J. Nutr."},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2013.05.016"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024429032116"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i17.2005"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)90541-9"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/pr0601584"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00161.2015"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00597-6"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.11.028"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.28.061807.155438"},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"1557S","DOI":"10.1093\/jn\/135.6.1557S","volume":"135","author":"Hutson S. M.","year":"2005","journal-title":"J. Nutr."},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/736837"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1876"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M604370200"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23639"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.8.1040"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(89)80010-5"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P000331"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/jf048662l"},{"key":"ref70\/cit70","first-page":"292","volume":"13","author":"Lord R. S.","year":"2008","journal-title":"Altern. Med. Rev."},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20156487"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/jf9028392"},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1093\/ajcn\/77.4.912","volume":"77","author":"Rios L. Y.","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1021\/jf0108056"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309332992"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1065"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1080\/10715760801999727"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001417"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2012.07.002"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.09-91"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.09.026"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2000.03322.x"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.05.005"},{"key":"ref84\/cit84","volume-title":"Principles of Biochemistry","author":"Lehninger A. L.","year":"1993"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.7.2101013"},{"key":"ref86\/cit86","volume-title":"Redox Biochemistry","author":"Banerjee R.","year":"2008"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.07.010"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds193"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-009-0249-0"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114669"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-015-0274-1"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2013.05.017"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2016.06.004"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.6b00238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T07:52:12Z","timestamp":1682149932000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.6b00238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,30]]},"references-count":93,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10,7]]}},"alternative-id":["10.1021\/acs.jproteome.6b00238"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.6b00238","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,30]]}}}