{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:52:02Z","timestamp":1788267122782,"version":"build-2803163510"},"reference-count":126,"publisher":"American Chemical Society (ACS)","issue":"9","funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["1 U24 DK097193-01"],"award-info":[{"award-number":["1 U24 DK097193-01"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008199","name":"RTI International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2016,9,2]]},"DOI":"10.1021\/acs.jproteome.6b00430","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T09:27:46Z","timestamp":1469179666000},"page":"3225-3240","source":"Crossref","is-referenced-by-count":52,"title":["Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences"],"prefix":"10.1021","volume":"15","author":[{"given":"Delisha A.","family":"Stewart","sequence":"first","affiliation":[{"name":"NIH Eastern Regional Comprehensive Metabolomics Resource Core, RTI International, Research Triangle Park, North Carolina 27709, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason H.","family":"Winnike","sequence":"additional","affiliation":[{"name":"David H. Murdock Research Institute, Kannapolis, North Carolina 28081, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"McRitchie","sequence":"additional","affiliation":[{"name":"NIH Eastern Regional Comprehensive Metabolomics Resource Core, RTI International, Research Triangle Park, North Carolina 27709, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Clark","sequence":"additional","affiliation":[{"name":"NIH Eastern Regional Comprehensive Metabolomics Resource Core, RTI International, Research Triangle Park, North Carolina 27709, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wimal W.","family":"Pathmasiri","sequence":"additional","affiliation":[{"name":"NIH Eastern Regional Comprehensive Metabolomics Resource Core, RTI International, Research Triangle Park, North Carolina 27709, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Sumner","sequence":"additional","affiliation":[{"name":"NIH Eastern Regional Comprehensive Metabolomics Resource Core, RTI International, Research Triangle Park, North Carolina 27709, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"ref1\/cit1","unstructured":"LBBC Living BeyondBreast Cancer Guide To UnderstandingTriple-Negative Breast Cancer. http:\/\/www.tnbcfoundation.org\/LBBCGuideUnderstandingTripleNegPrint2013.pdf."},{"key":"ref2\/cit2","unstructured":"Surveillance, Epidemiology, and End Results (SEER) Program SEER Stat Fact Sheets: Breast Cancer.http:\/\/seer.cancer.gov\/statfacts\/html\/breast.html(accessed 26 April 2015) ."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1109"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/219869"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2013.00250"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1001389"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3205-1"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.05.037"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2780"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3156"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3556"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.21.2492"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-007-9632-6"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp036"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9472-2"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25862"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3341"},{"key":"ref18\/cit18","unstructured":"ACS Guidelines for the Early Detection of Cancer.http:\/\/www.cancer.org\/healthy\/findcancerearly\/cancerscreeningguidelines\/american-cancer-society-guidelines-for-the-early-detection-of-cancer(accessed 28 April 2015) ."},{"issue":"1","key":"ref19\/cit19","first-page":"55","volume":"14","author":"Warburg O.","year":"1958","journal-title":"Acta Unio Int. Cancrum"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.02.024"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2012.08644.x"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/nature11706"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/srep04927"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.02.016"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2009.01.005"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.12.007"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201200143"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-013-0517-x"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/pr300111x"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2004.00142.x"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-11-0110"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.69"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28623"},{"issue":"9","key":"ref35\/cit35","first-page":"3118","volume":"40","author":"Brinkley B. R.","year":"1980","journal-title":"Cancer Res."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1007\/BF02616120"},{"issue":"3","key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/jnci\/53.3.661","volume":"53","author":"Cailleau R.","year":"1974","journal-title":"J. Natl. Cancer Inst."},{"issue":"2","key":"ref38\/cit38","first-page":"263","volume":"62","author":"Pathak S.","year":"1979","journal-title":"J. Natl. Cancer Inst."},{"issue":"3","key":"ref39\/cit39","first-page":"919","volume":"39","author":"Siciliano M. J.","year":"1979","journal-title":"Cancer Res."},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2013.10.002"},{"issue":"6","key":"ref41\/cit41","first-page":"279","volume":"11","author":"Kanaan Y. M.","year":"2014","journal-title":"Cancer Genomics Proteomics"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.02.006"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-011-0388-y"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-010-0249-0"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.376"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1462"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1503"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-010-0197-8"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-012-0404-x"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-011-0396-y"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu094"},{"issue":"1","key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Benjamini Y.","year":"1995","journal-title":"J. R. Stat. Soc., Ser. B-Methodological"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/35021093"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191367098"},{"issue":"1","key":"ref55\/cit55","first-page":"80","volume":"59","author":"Aboagye E. O.","year":"1999","journal-title":"Cancer Res."},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3829"},{"issue":"7","key":"ref57\/cit57","first-page":"1966","volume":"62","author":"Katz-Brull R.","year":"2002","journal-title":"Cancer Res."},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2012.15.3.306"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-3043"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1554"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-013-9484-y"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00301.2013"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15069422"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-013-1490-y"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000045"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.4103\/2278-330X.119895"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2160"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4037"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.2217\/fon.14.117"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.01.008"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.2217\/fon.13.199"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210097"},{"issue":"6","key":"ref73\/cit73","first-page":"639","volume":"6","author":"Li J.","year":"2005","journal-title":"Curr. Opin Invest. Drugs"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0714-607b"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2291"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0149"},{"issue":"2","key":"ref77\/cit77","first-page":"61","volume":"13","author":"Ahmed O. I.","year":"2006","journal-title":"Egypt J. Immunol."},{"key":"ref78\/cit78","first-page":"82","volume":"48","author":"Kozlowski L.","year":"2003","journal-title":"Rocz. Akad. Med. Bialymstoku"},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1359\/jbmr.0301212","volume":"19","author":"Tometsko M.","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063153"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.277"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.4161\/auto.34398"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-015-0538-7"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.19.14307"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2013.08.002"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-70"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-11-0604"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(00)00023-8"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs387"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.634"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24441"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1827"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2014.05.007"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1683"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-63"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2009.09.003"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283335277"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra072067"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1152"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2010.13"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100011"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1292"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2012.63"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.08.022"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2010.487163"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.075"},{"issue":"3","key":"ref108\/cit108","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0022-3565(25)38591-5","volume":"268","author":"Kumar G. N.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"ref109\/cit109","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S0022-3565(25)12102-2","volume":"275","author":"Sonnichsen D. S.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200110000-00006"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500434"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2345"},{"issue":"1","key":"ref113\/cit113","first-page":"65","volume":"58","author":"Bailey L. R.","year":"1998","journal-title":"Cancer Res."},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4801"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2009.04.009"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2013.17.6.479"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e3182277e3b"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-012-0592-z"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.3109\/10409239509083491"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(96)00051-2"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1081\/DMR-120015695"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.2165\/00129785-200303030-00002"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206940"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00778.2003"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-012-0185-y"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1822"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.6b00430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T23:57:33Z","timestamp":1748995053000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.6b00430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":126,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9,2]]}},"alternative-id":["10.1021\/acs.jproteome.6b00430"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.6b00430","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}