{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:45:53Z","timestamp":1790703953378,"version":"4.1.0"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T00:00:00Z","timestamp":1486598400000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100007436","name":"Familjen Erling-Perssons Stiftelse","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100007436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The underlying molecular mechanisms of autoimmune diseases are poorly understood. To unravel the autoimmune processes across diseases, comprehensive and unbiased analyses of proteins targets recognized by the adaptive immune system are needed. Here we present an approach starting from high-density peptide arrays to characterize autoantibody repertoires and to identify new autoantigens. A set of ten plasma and serum samples from subjects with multiple sclerosis, narcolepsy, and without any disease diagnosis were profiled on a peptide array representing the whole proteome, hosting 2.2 million 12-mer peptides with a six amino acid lateral shift. On the basis of the IgG reactivities found on these whole-proteome peptide microarrays, a set of 23 samples was then studied on a targeted array with 174\u202f000 12-mer peptides of single amino acid lateral shift. Finally, verification of IgG reactivities was conducted with a larger sample set (n = 448) using the bead-based peptide microarrays. The presented workflow employed three different peptide microarray formats to discover and resolve the epitopes of human autoantibodies and revealed two potentially new autoantigens: MAP3K7 in multiple sclerosis and NRXN1 in narcolepsy. The presented strategy provides insights into antibody repertoire reactivity at a peptide level and may accelerate the discovery and validation of autoantigens in human diseases.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6b00916","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T12:28:33Z","timestamp":1485347313000},"page":"1300-1314","source":"Crossref","is-referenced-by-count":72,"title":["Whole-Proteome\nPeptide Microarrays for Profiling Autoantibody\nRepertoires within Multiple Sclerosis and Narcolepsy"],"prefix":"10.1021","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1242-0873","authenticated-orcid":true,"given":"Arash","family":"Zandian","sequence":"first","affiliation":[{"name":"KTH - Royal Institute of Technology , , ,","place":["Solna, Sweden, SE-171 21"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjo\u0308rn","family":"Forsstro\u0308m","sequence":"additional","affiliation":[{"name":"KTH - Royal Institute of Technology , , ,","place":["Solna, Sweden, SE-171 21"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ha\u0308ggmark-Ma\u030anberg","sequence":"additional","affiliation":[{"name":"KTH - Royal Institute of Technology , , ,","place":["Solna, Sweden, SE-171 21"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen M.","family":"Schwenk","sequence":"additional","affiliation":[{"name":"KTH - Royal Institute of Technology , , ,","place":["Solna, Sweden, SE-171 21"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Uhle\u0301n","sequence":"additional","affiliation":[{"name":"KTH - Royal Institute of Technology , , ,","place":["Solna, Sweden, SE-171 21"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nilsson","sequence":"additional","affiliation":[{"name":"KTH - Royal Institute of Technology , , ,","place":["Solna, Sweden, SE-171 21"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-2960","authenticated-orcid":true,"given":"Burcu","family":"Ayoglu","sequence":"additional","affiliation":[{"name":"KTH - Royal Institute of Technology , , ,","place":["Solna, Sweden, SE-171 21"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,1,25]]},"reference":[{"issue":"42","key":"2026090309363843700_cit1","doi-asserted-by":"publisher","first-page":"9217","DOI":"10.1016\/S0040-4020(01)85612-X","article-title":"Spot-synthesis:\nan easy technique for the positionally addressable, parallel chemical\nsynthesis on a membrane support","volume":"48","author":"Frank","year":"1992","journal-title":"Tetrahedron"},{"issue":"4995","key":"2026090309363843700_cit2","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1126\/science.1990438","article-title":"Light-directed, spatially addressable parallel chemical synthesis","volume":"251","author":"Fodor","year":"1991","journal-title":"Science"},{"issue":"10","key":"2026090309363843700_cit3","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/13664","article-title":"Maskless fabrication\nof light-directed\noligonucleotide microarrays using a digital micromirror array","volume":"17","author":"Singh-Gasson","year":"1999","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"2026090309363843700_cit4","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1021\/cc100009g","article-title":"Automated maskless\nphotolithography\nsystem for peptide microarray synthesis on a chip","volume":"12","author":"Shin","year":"2010","journal-title":"J. Comb. Chem."},{"issue":"11","key":"2026090309363843700_cit5","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1002\/pmic.200300597","article-title":"Light directed\nmassively parallel\non-chip synthesis of peptide arrays with t-Boc chemistry","volume":"3","author":"Gao","year":"2003","journal-title":"Proteomics"},{"issue":"9","key":"2026090309363843700_cit6","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/nm.2913","article-title":"On silico peptide\nmicroarrays for high-resolution mapping\nof antibody epitopes and diverse protein-protein interactions","volume":"18","author":"Price","year":"2012","journal-title":"Nat. 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Neurol."},{"issue":"8","key":"2026090309363843700_cit28","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1212\/WNL.0b013e318247f9f3","article-title":"Antigen microarrays identify CNS-produced autoantibodies\nin RRMS","volume":"78","author":"Quintana","year":"2012","journal-title":"Neurology"},{"issue":"2","key":"2026090309363843700_cit29","doi-asserted-by":"publisher","first-page":"e204","DOI":"10.1212\/NXI.0000000000000204","article-title":"Serum peptide reactivities may distinguish\nneuromyelitis optica subgroups and multiple sclerosis","volume":"3","author":"Metz","year":"2016","journal-title":"Neurology Neuroimmunology & Neuroinflammation"},{"issue":"6","key":"2026090309363843700_cit30","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/ng.372","article-title":"Narcolepsy\nis strongly associated\nwith the T-cell receptor alpha locus","volume":"41","author":"Hallmayer","year":"2009","journal-title":"Nat. Genet."},{"key":"2026090309363843700_cit31","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.phrs.2014.10.005","article-title":"Is narcolepsy\na classical autoimmune\ndisease?","volume":"92","author":"Arango","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"5","key":"2026090309363843700_cit32","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.conb.2013.04.013","article-title":"The autoimmune basis\nof narcolepsy","volume":"23","author":"Mahlios","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"issue":"3","key":"2026090309363843700_cit33","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1002\/ana.22587","article-title":"Narcolepsy\nonset is seasonal and increased following the 2009 H1N1 pandemic in\nchina","volume":"70","author":"Han","year":"2011","journal-title":"Ann. 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Rev. Allergy Immunol."},{"issue":"1\u20132","key":"2026090309363843700_cit49","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.molimm.2012.06.001","article-title":"Structural analysis\nof B-cell epitopes in antibody:protein complexes","volume":"53","author":"Kringelum","year":"2013","journal-title":"Mol. Immunol."},{"issue":"8","key":"2026090309363843700_cit50","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1073\/pnas.1518553113","article-title":"Anoctamin 2 identified as an autoimmune target in multiple\nsclerosis","volume":"113","author":"Ayoglu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"2026090309363843700_cit51","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4049\/jimmunol.138.2.593","article-title":"The glycine-alanine\nrepeating region is the major epitope of the Epstein-Barr nuclear\nantigen-1 (EBNA-1)","volume":"138","author":"Rumpold","year":"1987","journal-title":"J. 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