{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:36:17Z","timestamp":1789677377712,"version":"4.0.1"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","award":["CB11285"],"award-info":[{"award-number":["CB11285"]}],"id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Microphysiological systems (MPSs) are gaining traction as a viable alternative model for toxicity studies. Further characterization is necessary to explore the full translational potential of MPSs to human physiology, along with the utility of these platforms to serve as a diagnostic tool. Multiomics analyses have emerged as a key means for identifying host biomarkers associated with chemical and drug exposure. Correlations between published human omics and MPS technology omics data will inform the potential of organ chips to accurately represent human responses and provide an alternative approach for improved biomarker discovery for toxicity assessment and exposure identification. To interrogate these potential overlaps, TissUse Chip3 multiorgan chips (MOCs) seeded with kidney organoids, liver organoids, and respiratory tract tissue were exposed to low, therapeutic, and toxic doses of acetaminophen (n = 4 for each condition) for 24 h and subjected to proteomic and metabolomic analysis. The data from our organ chips are largely consistent with biomarkers and dysregulations identified in published human omics data, in vitro and in vivo data, to include the identification of several known acetaminophen metabolites and biotransformation products. These data suggest that organ chips may be a suitable surrogate for human biomarker identification and drug or hazardous chemical exposure diagnosis.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00120","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T17:02:09Z","timestamp":1785949329000},"page":"4599-4613","source":"Crossref","is-referenced-by-count":1,"title":["Exploring\nthe Translation of Organ-on-a-Chip Technology\nfor Human-Relevant Diagnostic Biomarkers"],"prefix":"10.1021","volume":"25","author":[{"given":"Conor C.","family":"Jenkins","sequence":"first","affiliation":[{"name":"U.S. Army Combat Capabilities Development Command (DEVCOM) Chemical Biological Center (CBC) , 5183 Blackhawk Rd., Aberdeen Proving Ground , , ,","place":["Gunpowder, Maryland, United States, 21010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0630-7577","authenticated-orcid":true,"given":"Priscilla E.","family":"Lee","sequence":"additional","affiliation":[{"name":"U.S. Army Combat Capabilities Development Command (DEVCOM) Chemical Biological Center (CBC) , 5183 Blackhawk Rd., Aberdeen Proving Ground , , ,","place":["Gunpowder, Maryland, United States, 21010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan H.","family":"Fudge","sequence":"additional","affiliation":[{"name":"U.S. Army Combat Capabilities Development Command (DEVCOM) Chemical Biological Center (CBC) , 5183 Blackhawk Rd., Aberdeen Proving Ground , , ,","place":["Gunpowder, Maryland, United States, 21010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1291-9332","authenticated-orcid":true,"given":"Gabrielle M.","family":"Rizzo","sequence":"additional","affiliation":[{"name":"U.S. Army Combat Capabilities Development Command (DEVCOM) Chemical Biological Center (CBC) , 5183 Blackhawk Rd., Aberdeen Proving Ground , , ,","place":["Gunpowder, Maryland, United States, 21010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6509-6053","authenticated-orcid":true,"given":"Allison E.","family":"Clay","sequence":"additional","affiliation":[{"name":"Precise Systems , 22290 Exploration Dr. , , ,","place":["Lexington Park, Maryland, United States, 20653"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel L.","family":"Shortt-Jackson","sequence":"additional","affiliation":[{"name":"Precise Systems , 22290 Exploration Dr. , , ,","place":["Lexington Park, Maryland, United States, 20653"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoshanah M.","family":"Myska","sequence":"additional","affiliation":[{"name":"Muhlenberg College , 2400 Chew Street , , ,","place":["Allentown, Pennsylvania, United States, 18104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Angelini","sequence":"additional","affiliation":[{"name":"U.S. Army Combat Capabilities Development Command (DEVCOM) Chemical Biological Center (CBC) , 5183 Blackhawk Rd., Aberdeen Proving Ground , , ,","place":["Gunpowder, Maryland, United States, 21010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-5598","authenticated-orcid":true,"given":"Elizabeth S.","family":"Dhummakupt","sequence":"additional","affiliation":[{"name":"U.S. Army Combat Capabilities Development Command (DEVCOM) Chemical Biological Center (CBC) , 5183 Blackhawk Rd., Aberdeen Proving Ground , , ,","place":["Gunpowder, Maryland, United States, 21010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler D. P.","family":"Goralski","sequence":"additional","affiliation":[{"name":"U.S. Army Combat Capabilities Development Command (DEVCOM) Chemical Biological Center (CBC) , 5183 Blackhawk Rd., Aberdeen Proving Ground , , ,","place":["Gunpowder, Maryland, United States, 21010"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"2026090409134550100_cit1","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1039\/D3LC00994G","article-title":"From Animal\nTesting to in Vitro Systems: Advancing Standardization in Microphysiological\nSystems","volume":"24","author":"Reyes","year":"2024","journal-title":"Lab Chip."},{"issue":"2","key":"2026090409134550100_cit2","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1089\/aivt.2018.0004","article-title":"Prevalidation of\nan Acute Inhalation Toxicity Test Using the EpiAirway in Vitro Human\nAirway Model","volume":"4","author":"Jackson","year":"2018","journal-title":"Appl. In Vitro Toxicol."},{"issue":"1","key":"2026090409134550100_cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42171-z","article-title":"A Human Lung Alveolus-on-a-Chip\nModel of Acute Radiation-Induced Lung Injury","volume":"14","author":"Dasgupta","year":"2023","journal-title":"Nat. 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Res."},{"key":"2026090409134550100_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106388","article-title":"Acetaminophen Metabolism Revisited Using Non-Targeted\nAnalyses: Implications for Human Biomonitoring","volume":"149","author":"David","year":"2021","journal-title":"Environ. Int."},{"issue":"3","key":"2026090409134550100_cit10","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.taap.2012.01.009","article-title":"Omics\nAnalysis of Low Dose Acetaminophen Intake Demonstrates Novel Response\nPathways in Humans","volume":"259","author":"Jetten","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2026090409134550100_cit11","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.12.1499","article-title":"Acetaminophen-Induced Hepatotoxicity","volume":"31","author":"James","year":"2003","journal-title":"Drug Metab. 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Pharmacol."},{"key":"2026090409134550100_cit30","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.fct.2018.03.014","article-title":"Lipin Deactivation\nafter Acetaminophen Overdose Causes Phosphatidic Acid Accumulation\nin Liver and Plasma in Mice and Humans and Enhances Liver Regeneration","volume":"115","author":"Lutkewitte","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"2026090409134550100_cit31","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/imr.12500","article-title":"Complement\nComponent C3 \u2013 The \u201cSwiss Army Knife\u201d of Innate\nImmunity and Host Defense","volume":"274","author":"Ricklin","year":"2016","journal-title":"Immunol. Rev."},{"issue":"2","key":"2026090409134550100_cit32","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1124\/jpet.111.189837","article-title":"Complement\nActivation in Acetaminophen-Induced\nLiver Injury in Mice","volume":"341","author":"Singhal","year":"2012","journal-title":"J. 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