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Despite its prevalence, no FDA-approved therapies exist for CIPN prevention or treatment, highlighting the need for target prioritzation studies. Using label-free liquid chromatography\u2013electrospray ionization tandem mass spectrometry (LC-ESI-MS\/MS), we examined the effects of four doses of paclitaxel (8 mg\/kg) on the lumbar (L4\u2013L6) spinal cord proteome in MMTV-PyMT-derived breast cancer bearing C57BL\/6J mice. Breast cancer altered the expression of 551 proteins relative to nai\u0308ve mice, while paclitaxel treatment in tumor-bearing mice altered 112 proteins relative to vehicle-treated cancer controls. Thirty-eight proteins were commonly affected by both conditions. Gene ontology enrichment and STRING protein\u2013protein interaction analyses identified pathways linked to mitochondrial metabolism, ion transport, and neurotransmitter signaling. Pathway mapping further revealed convergent effects of breast cancer and paclitaxel on neuronal activation, neurotransmitter uptake, and mitochondrial dysfunction. Together, these findings define spinal cord proteomic alterations associated with acute paclitaxel-induced peripheral neuropathy and identify pain-relevant pathways for future mechanistic studies.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00124","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:11:27Z","timestamp":1784819487000},"page":"4072-4085","source":"Crossref","is-referenced-by-count":1,"title":["Proteomic Adaptations\nin the Spinal Cord of a Breast\nCancer Model of Paclitaxel-Induced Peripheral Neuropathy"],"prefix":"10.1021","volume":"25","author":[{"given":"Samantha P.","family":"Schwarting","sequence":"first","affiliation":[{"name":"George Mason University , , , ,","place":["Manassas, Virginia, United States, 20110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-5972","authenticated-orcid":true,"given":"Virginia","family":"Espina","sequence":"additional","affiliation":[{"name":"Center for Applied Proteomics and Molecular Medicine , , ,","place":["Manassas, Virginia, United States, 20110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Russo","sequence":"additional","affiliation":[{"name":"Center for Applied Proteomics and Molecular Medicine , , ,","place":["Manassas, Virginia, United States, 20110"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Herz","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University , , , ,","place":["Richmond, Virginia, United States, 23298"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrar","family":"Khan","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University , , , ,","place":["Richmond, Virginia, United States, 23298"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2963-9995","authenticated-orcid":true,"given":"Yogesh","family":"Rakholia","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University , , , ,","place":["Richmond, Virginia, United States, 23298"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Makar","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University School of Medicine , , , ,","place":["Richmond, Virginia, United States, 23298"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula D.","family":"Bos","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University School of Medicine , , , ,","place":["Richmond, Virginia, United States, 23298"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8859-029X","authenticated-orcid":true,"given":"M. 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