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In this study, we performed a six-week longitudinal proteomic analysis of 197 plasma samples collected weekly from 44 hospitalized COVID-19 patients. Temporal profiling revealed 828 proteins with significant time-dependent abundance changes, clustering into an early acute-phase and inflammatory response group that gradually declined toward the cohort\u2019s overall mean profile over time and a group of late vesicle-mediated transport and antigen binding that were decreased in the first weeks. Global correlation mapping identified six coregulated protein modules, notably including insulin-like growth factor binding proteins. Proteomic divergence between survivors and nonsurvivors became pronounced from week 4 onward. The proteins HPR, IGFALS, PF4, LPA, and COLEC11 achieved AUCs &amp;gt; 0.72 for mortality prediction in the first 2 weeks, and an SVM model combining these markers yielded an AUC of 0.801. These findings demonstrate that plasma proteome trajectories capture dynamic host responses and generate candidate prognostic markers, offering a promising strategy for risk stratification and guiding targeted interventions in COVID-19.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00129","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:19:18Z","timestamp":1785849558000},"page":"4086-4098","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Proteomic\nProfiling of Hospitalized COVID-19\nPatients Reveals Prognostic Biomarkers"],"prefix":"10.1021","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3958-8190","authenticated-orcid":true,"given":"Mauricio","family":"Quin\u0303ones-Vega","sequence":"first","affiliation":[{"name":"Federal University of Rio de Janeiro (UFRJ) , , ,","place":["Rio de Janeiro, Brazil, 21941-901"]},{"name":"Federal University of Rio de Janeiro (UFRJ) , , ,","place":["Rio de Janeiro, Brazil, 21941-901"]},{"name":"Federal University of Rio de Janeiro (UFRJ) , , ,","place":["Rio de Janeiro, Brazil, 21941-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3112-2329","authenticated-orcid":true,"given":"Patricia","family":"Sosa-Acosta","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro (UFRJ) , , ,","place":["Rio de Janeiro, Brazil, 21941-901"]},{"name":"Federal University of Rio de Janeiro (UFRJ) , , ,","place":["Rio de Janeiro, Brazil, 21941-901"]},{"name":"Federal University of Rio de Janeiro (UFRJ) , , ,","place":["Rio de Janeiro, Brazil, 21941-901"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Ca\u0302mara","family":"Giudicelli","sequence":"additional","affiliation":[{"name":"Hospital de Cli\u0301nicas de Porto Alegre (HCPA) , , ,","place":["Porto Alegre, Brazil, 90035-903"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marile\u0301a Furtado","family":"Feira","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Sul (UFRGS) , , ,","place":["Porto Alegre, Brazil, 90035-903"]},{"name":"Hospital de Cli\u0301nicas de Porto Alegre (HCPA) , , ,","place":["Porto Alegre, Brazil, 90035-903"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibiana S. 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