{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:52:57Z","timestamp":1790949177460,"version":"4.1.0"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda??o de Amparo ? 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We refined this model by inoculating 9.5 day embryos via allantois with a low SP dose and evaluating outcomes at 24 and 48 h postinfection. This approach aims to provide a framework for systematically exploring early molecular events triggered by infection and inflammation while using the CE as an ethically acceptable and biologically relevant model of systemic inflammation. Clinical parameters (mortality and weight), serum proteomics, and untargeted metabolomics were assessed. Proteomics was performed by LC\u2013MS\/MS, followed by PANTHER and KEGG functional enrichment; metabolomics was performed to assess serum alterations. Mortality increased at 48 h postinfection (30%), and surviving embryos showed a trend toward reduced weight. Proteomic profiling revealed an increase in overall protein concentrations in the infected group compared to the control, despite high zero inflation, with \u03b1-2-macroglobulin significantly upregulated at 48 h, indicating an endogenous immune response. For pathway-level enrichment, Bayesian analysis suggested subtle effects on proteome dynamics. Metabolomics identified time-dependent changes, including increased levels of \u03b1-tocopherol-related and phenylalanine-derived metabolites and decreased levels of oxidized fatty acid derivatives at 48 h. These findings support the CE model before 12 days as an ethically refined and sensitive system for studying acute inflammatory responses.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00153","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:57:30Z","timestamp":1788429450000},"page":"5159-5172","source":"Crossref","is-referenced-by-count":0,"title":["Integrated\nProteomics and Metabolomics Can Shed Light\non Potential Biomarkers of Inflammation and Infection in Chicken Embryos\nas an Experimental Model"],"prefix":"10.1021","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1882-4158","authenticated-orcid":true,"given":"Simone","family":"Sommerfeld","sequence":"first","affiliation":[{"name":"Graduate Program of Veterinary Science of Federal University of Uberla\u0302ndia , Rua Ceara\u0301 Bloco2D, Campus Umuarama\u2500Bairro Umuarama , , ,","place":["Uberla\u0302ndia, MG, Brazil, CEP 38405-302"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebreia Oliveira Almeida","family":"Souza","sequence":"additional","affiliation":[{"name":"Graduate Program of Genetics and Biochemistry of Federal University of Uberla\u0302ndia Rua AcreBloco 2E , Campus Umuarama\u2500Bairro Umuarama , , ,","place":["Uberla\u0302ndia, MG, Brazil, CEP 38400-902"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Machado","family":"Martins","sequence":"additional","affiliation":[{"name":"Graduate Program of Genetics and Biochemistry of Federal University of Uberla\u0302ndia Rua AcreBloco 2E , Campus Umuarama\u2500Bairro Umuarama , , ,","place":["Uberla\u0302ndia, MG, Brazil, CEP 38400-902"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Uliana","family":"Picolo","sequence":"additional","affiliation":[{"name":"Graduate Program of Genetics and Biochemistry of Federal University of Uberla\u0302ndia Rua AcreBloco 2E , Campus 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Biochemistry of Federal University of Uberla\u0302ndia Rua AcreBloco 2E , Campus Umuarama\u2500Bairro Umuarama , , ,","place":["Uberla\u0302ndia, MG, Brazil, CEP 38400-902"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Silva Vieira","sequence":"additional","affiliation":[{"name":"Graduate Program of Veterinary Science of Federal University of Uberla\u0302ndia , Rua Ceara\u0301 Bloco2D, Campus Umuarama\u2500Bairro Umuarama , , ,","place":["Uberla\u0302ndia, MG, Brazil, CEP 38405-302"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara Reis","family":"Gomes","sequence":"additional","affiliation":[{"name":"Graduate Program of Veterinary Science of Federal University of Uberla\u0302ndia , Rua Ceara\u0301 Bloco2D, Campus Umuarama\u2500Bairro Umuarama , , ,","place":["Uberla\u0302ndia, MG, Brazil, CEP 38405-302"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo Vieira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Graduate Program of Veterinary Science of Federal University of Uberla\u0302ndia , Rua Ceara\u0301 Bloco2D, Campus Umuarama\u2500Bairro Umuarama , , ,","place":["Uberla\u0302ndia, MG, Brazil, CEP 38405-302"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Aguiar de Souza Penha","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Foundation , , , ,","place":["Rio de Janeiro, Rio de Janeiro, Brazil, 21040-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8485-078X","authenticated-orcid":true,"given":"Belchiolina Beatriz","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Graduate Program of Veterinary Science of Federal University of Uberla\u0302ndia , Rua Ceara\u0301 Bloco2D, Campus Umuarama\u2500Bairro Umuarama , , ,","place":["Uberla\u0302ndia, MG, Brazil, CEP 38405-302"]},{"name":"Graduate Program of Genetics and 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Macromol."},{"key":"2026100208413804600_cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2021.104258","article-title":"Proteomic\nAnalysis of Liver Tissues in Chicken Embryo at Day 16 and Day 20 Reveals\nAntioxidant Mechanisms","volume":"243","author":"Yang","year":"2021","journal-title":"J. Proteomics"},{"issue":"1","key":"2026100208413804600_cit30","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-4427-6","article-title":"Proteomics\nReveals Changes in Hepatic Proteins during Chicken Embryonic Development:\nAn Alternative Model to Study Human Obesity","volume":"19","author":"Peng","year":"2018","journal-title":"BMC Genomics"},{"issue":"3","key":"2026100208413804600_cit31","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1189\/jlb.0212056","article-title":"Plasmin as a Proinflammatory\nCell\nActivator","volume":"92","author":"Syrovets","year":"2012","journal-title":"J. Leukoc. 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