{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:29:55Z","timestamp":1788532195899,"version":"build-2803163510"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["HCP0008"],"award-info":[{"award-number":["HCP0008"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["HCP0023"],"award-info":[{"award-number":["HCP0023"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["JCB\/2021\/000042"],"award-info":[{"award-number":["JCB\/2021\/000042"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CSIR-Centre for Cellular and Molecular Biology, Hyderabad","award":["MLP002604"],"award-info":[{"award-number":["MLP002604"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sickle Cell Anaemia (SCA) is a monogenic blood disorder caused by a mutation in the \u03b2-globin gene, yet it presents with marked clinical variability. Although hydroxyurea (HU) is an established therapy, its precise mechanism of action remains incompletely understood. Plasma proteins represent valuable biomarkers for elucidating disease mechanisms and treatment responses. In this study, plasma proteome profiling of 31 healthy controls and 76 SCA patients identified 43 differentially abundant proteins (DAPs) that form a highly interconnected interaction network. Proteins with increased abundance in SCA were largely associated with immune and inflammatory responses, whereas those with reduced levels were linked to coagulation and proteolytic pathways. HU therapy was associated with elevated levels of haptoglobin (HP) and hemopexin (HPX), key mediators of free hemoglobin scavenging. We also identified several previously unreported plasma proteins altered in SCA, broadening the landscape of potential biomarkers and HU-responsive targets. Many DAPs significantly correlated with clinical indices, such as transfusion frequency, vaso-occlusive crises, white blood cell counts, and platelet counts, offering insights into disease mechanisms and potential utility in disease management. Notably, overlap with \u03b2-thalassemia-associated signatures suggests shared pathophysiological pathways between these hemoglobinopathies. Collectively, these findings provide a strong foundation for translational validation in larger, independent cohorts.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00158","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:02:33Z","timestamp":1786716153000},"page":"4624-4635","source":"Crossref","is-referenced-by-count":0,"title":["Plasma Proteome\nSignatures in Sickle Cell Anemia and\nthe Effect of Hydroxyurea Treatment"],"prefix":"10.1021","volume":"25","author":[{"given":"Neha","family":"Kumari","sequence":"first","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Paliwal","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushri","family":"Umesh","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4696-1372","authenticated-orcid":true,"given":"Gopinath","family":"Palanisamy","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayalakshmi","family":"Marneni","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6345-3353","authenticated-orcid":true,"given":"Sristi","family":"Chakroborty","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raman","family":"Bakthisaran","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kameswari","family":"Yele","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjith Kumar","family":"K.","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj Singh","family":"Nongmaithem","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasupuleti Sri Kanya Durga Bhavani","family":"Punyasri","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep K.","family":"Patra","sequence":"additional","affiliation":[{"name":"Pt. Deendayal Upadhyay Memorial Health Science and Ayush University of Chhattisgarh , , ,","place":["Naya Raipur, Chhattisgarh, India, 493661"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipty","family":"Jain","sequence":"additional","affiliation":[{"name":"Arihant Multispeciality Hospital , , ,","place":["Nagpur, Maharashtra, India, 440026"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swasti","family":"Raychaudhuri","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-9453","authenticated-orcid":true,"given":"Giriraj Ratan","family":"Chandak","sequence":"additional","affiliation":[{"name":"CSIR-Centre for Cellular and Molecular Biology , , ,","place":["Hyderabad, Telangana, India, 500007"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"issue":"1","key":"2026090409133257300_cit1","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1136\/archdischild-2013-303773","article-title":"Sickle Cell Disease:\nA Neglected Chronic Disease of\nIncreasing Global Health Importance","volume":"100","author":"Chakravorty","year":"2015","journal-title":"Arch. Dis.\nChild."},{"issue":"8","key":"2026090409133257300_cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00118-7","article-title":"Global,\nregional, and national prevalence and\nmortality burden of sickle cell disease, 2000\u20132021: a systematic\nanalysis from the Global Burden of Disease Study 2021","volume":"10","author":"Thomson","year":"2023","journal-title":"Lancet Haematol."},{"key":"2026090409133257300_cit3","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/ncomms1104","article-title":"Global Distribution\nof the Sickle Cell Gene and Geographical Confirmation of the Malaria\nHypothesis","volume":"1","author":"Piel","year":"2010","journal-title":"Nat. Commun."},{"issue":"1","key":"2026090409133257300_cit4","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4103\/ijmr.ijmr_1435_21","article-title":"Sickle Cell Disease: More than a Century of Progress.\nWhere Do We Stand Now?","volume":"154","author":"Brousse","year":"2021","journal-title":"Indian J. Med. Res."},{"issue":"3","key":"2026090409133257300_cit5","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1097\/MOH.0000000000000582","article-title":"Effective Use of Hydroxyurea for Sickle Cell Anemia\nin Low-Resource Countries","volume":"27","author":"Power-Hays","year":"2020","journal-title":"Curr. Opin. Hematol."},{"issue":"1","key":"2026090409133257300_cit6","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0006-291X(68)90266-0","article-title":"Effect\nof Hydroxyurea on Ribonucleotide Reductase","volume":"33","author":"Elford","year":"1968","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"2026090409133257300_cit7","doi-asserted-by":"publisher","first-page":"4701","DOI":"10.1182\/blood.V88.12.4701.bloodjournal88124701","article-title":"A Multiparameter\nAnalysis of Sickle Erythrocytes in Patients Undergoing Hydroxyurea\nTherapy","volume":"88","author":"Bridges","year":"1996","journal-title":"Blood"},{"issue":"3","key":"2026090409133257300_cit8","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/1096-8652(200011)65:3&lt;227::AID-AJH9&gt;3.0.CO;2-V","article-title":"Mechanism\nfor Fetal Hemoglobin Induction by Hydroxyurea in Sickle Cell Erythroid\nProgenitors","volume":"65","author":"Baliga","year":"2000","journal-title":"Am. J. Hematol."},{"issue":"1","key":"2026090409133257300_cit9","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1074\/jbc.M303952200","article-title":"Hydroxyurea Arrests\nDNA Replication by a Mechanism That Preserves Basal dNTP Pools","volume":"279","author":"Koc\u0327","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"18","key":"2026090409133257300_cit10","doi-asserted-by":"publisher","first-page":"6396","DOI":"10.1128\/MCB.00719-07","article-title":"Replication\nin Hydroxyurea: It\u2019s a Matter of\nTime","volume":"27","author":"Alvino","year":"2007","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"2026090409133257300_cit11","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1172\/JCI16672","article-title":"Hydroxyurea\nInduces Fetal Hemoglobin\nby the Nitric Oxide-Dependent Activation of Soluble Guanylyl Cyclase","volume":"111","author":"Cokic","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"11","key":"2026090409133257300_cit12","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1517\/14740338.2015.1088827","article-title":"Hydroxyurea Therapy\nfor Sickle Cell Anemia","volume":"14","author":"McGann","year":"2015","journal-title":"Expert Opin. Drug Saf."},{"issue":"23","key":"2026090409133257300_cit13","doi-asserted-by":"publisher","first-page":"6326","DOI":"10.1002\/pmic.200600284","article-title":"Human Body Fluid Proteome Analysis","volume":"6","author":"Hu","year":"2006","journal-title":"Proteomics"},{"issue":"3","key":"2026090409133257300_cit14","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.jprot.2009.07.001","article-title":"The Dynamic Range Problem\nin the Analysis of the Plasma\nProteome","volume":"73","author":"Hortin","year":"2010","journal-title":"J. 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Biol."},{"issue":"1","key":"2026090409133257300_cit17","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1093\/bioinformatics\/btr597","article-title":"MissForest\u2013Non-Parametric\nMissing Value Imputation\nfor Mixed-Type Data","volume":"28","author":"Stekhoven","year":"2012","journal-title":"Bioinforma. Oxf. Engl."},{"issue":"1","key":"2026090409133257300_cit18","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1038\/s41598-021-81279-4","article-title":"A Comparative\nStudy of Evaluating Missing Value Imputation Methods\nin Label-Free Proteomics","volume":"11","author":"Jin","year":"2021","journal-title":"Sci. Rep."},{"issue":"8","key":"2026090409133257300_cit19","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: A\nGraphical Gene-Set Enrichment\nTool for Animals and Plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinforma. Oxf.\nEngl."},{"issue":"3","key":"2026090409133257300_cit20","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/s41588-025-02089-2","article-title":"Plasma Proteome Variation and Its\nGenetic Determinants in Children and Adolescents","volume":"57","author":"Niu","year":"2025","journal-title":"Nat. Genet."},{"issue":"4","key":"2026090409133257300_cit21","doi-asserted-by":"publisher","first-page":"104091","DOI":"10.1016\/j.isci.2022.104091","article-title":"Plasma Proteome Profiling Combined\nwith Clinical and Genetic Features\nReveals the Pathophysiological Characteristics of \u03b2-Thalassemia","volume":"25","author":"Li","year":"2022","journal-title":"iScience"},{"issue":"7","key":"2026090409133257300_cit22","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1177\/1535370216636726","article-title":"Minireview: Genetic Basis of Heterogeneity\nand Severity\nin Sickle Cell Disease","volume":"241","author":"Habara","year":"2016","journal-title":"Exp. Biol. Med."},{"issue":"3","key":"2026090409133257300_cit23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1097\/MOH.0000000000000422","article-title":"Clinical Manifestations of Sickle Cell Disease in India:\nMisconceptions and Reality","volume":"25","author":"Jain","year":"2018","journal-title":"Curr. Opin. Hematol."},{"issue":"2","key":"2026090409133257300_cit24","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/ijns5020020","article-title":"Sickle Cell Disease-Genetics, Pathophysiology,\nClinical Presentation and Treatment","volume":"5","author":"Inusa","year":"2019","journal-title":"Int. J.\nNeonat. Screening"},{"issue":"6","key":"2026090409133257300_cit25","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1097\/01.NAJ.0000559779.40570.2c","article-title":"CE: Understanding\nthe Complications of Sickle Cell Disease","volume":"119","author":"Tanabe","year":"2019","journal-title":"Am.\nJ. Nurs."},{"issue":"13","key":"2026090409133257300_cit26","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.1182\/bloodadvances.2022009202","article-title":"Long-Term Survival\nwith Sickle Cell Disease: A Nationwide Cohort\nStudy of Medicare and Medicaid Beneficiaries","volume":"7","author":"Jiao","year":"2023","journal-title":"Blood Adv."},{"issue":"20","key":"2026090409133257300_cit27","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1056\/NEJM199505183322001","article-title":"Effect of Hydroxyurea\non the Frequency of Painful Crises in Sickle Cell Anemia. Investigators\nof the Multicenter Study of Hydroxyurea in Sickle Cell Anemia","volume":"332","author":"Charache","year":"1995","journal-title":"N. Engl. J. Med."},{"issue":"22","key":"2026090409133257300_cit28","doi-asserted-by":"publisher","first-page":"4304","DOI":"10.1182\/blood-2012-03-419879","article-title":"Impact\nof Hydroxyurea on Clinical Events in the BABY HUG Trial","volume":"120","author":"Thornburg","year":"2012","journal-title":"Blood"},{"issue":"2","key":"2026090409133257300_cit29","doi-asserted-by":"publisher","first-page":"299","DOI":"10.4103\/ijmr.ijmr_3447_21","article-title":"A Systematic\nReview on Hydroxyurea Therapy for Sickle Cell Disease in India","volume":"156","author":"Pandey","year":"2022","journal-title":"Indian J. Med. Res."},{"issue":"14","key":"2026090409133257300_cit30","doi-asserted-by":"publisher","first-page":"3585","DOI":"10.1182\/bloodadvances.2024015564","article-title":"Evaluating the Long-Term Benefits\nof Hydroxyurea in\nPediatric Sickle Cell Anemia","volume":"9","author":"George","year":"2025","journal-title":"Blood Adv."},{"key":"2026090409133257300_cit31","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.3389\/fimmu.2019.01760","article-title":"Gal-3BP\nNegatively Regulates NF-\u03baB Signaling by Inhibiting the Activation\nof TAK1","volume":"10","author":"Hong","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"2026090409133257300_cit32","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1365-2141.2011.08800.x","article-title":"Resveratrol Ameliorates TNF\u03b1-mediated\nSuppression of Erythropoiesis in Human CD34+ Cells via\nModulation of NF-\u03baB Signalling","volume":"155","author":"Jeong","year":"2011","journal-title":"Br. J.\nHamaetol."},{"issue":"1","key":"2026090409133257300_cit33","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/pbc.22471","article-title":"Elevated\nSoluble Transferrin Receptor\nLevels Reflect Increased Erythropoietic Drive Rather than Iron Deficiency\nin Pediatric Sickle Cell Disease","volume":"55","author":"Lulla","year":"2010","journal-title":"Pediatr. Blood\nCancer"},{"issue":"12","key":"2026090409133257300_cit34","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.96910","article-title":"Intravascular Hemolysis Activates Complement via Cell-Free\nHeme and Heme-Loaded Microvesicles","volume":"3","author":"Merle","year":"2018","journal-title":"JCI Insight"},{"issue":"5","key":"2026090409133257300_cit35","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/j.1365-2141.2006.06074.x","article-title":"Sickle Cell Leg Ulcers: Associations\nwith Haemolysis and SNPs in Klotho, TEK and Genes of the TGF-Beta\/BMP\nPathway","volume":"133","author":"Nolan","year":"2006","journal-title":"Br. J. Hamaetol."},{"key":"2026090409133257300_cit36","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.21037\/jtd.2016.11.19","article-title":"The Role\nof Transforming Growth Factor (TGF)-\u03b2 in the Infarcted Myocardium","volume":"9","author":"Frangogiannis","year":"2017","journal-title":"J. Thorac. Dis."},{"key":"2026090409133257300_cit37","doi-asserted-by":"publisher","first-page":"3185015","DOI":"10.1155\/2020\/3185015","article-title":"Transforming Growth\nFactor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated\nwith Lipid Profile and Clinical Manifestations","volume":"2020","author":"Santiago","year":"2020","journal-title":"Mediators Inflammation"},{"key":"2026090409133257300_cit38","doi-asserted-by":"publisher","first-page":"4651891","DOI":"10.1155\/2021\/4651891","article-title":"Associations\nbetween TGF-\u03921 Levels and Markers of Hemolysis, Inflammation,\nand Tissue Remodeling in Pediatric Sickle Cell Patients","volume":"2021","author":"Santiago","year":"2021","journal-title":"Mediators Inflammation"},{"issue":"5","key":"2026090409133257300_cit39","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1177\/0267659109354656","article-title":"Safe Time Limits of\nAortic Cross-Clamping and Cardiopulmonary Bypass in Adult Cardiac\nSurgery","volume":"24","author":"Nissinen","year":"2009","journal-title":"Perfusion"},{"issue":"11","key":"2026090409133257300_cit40","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.2215\/CJN.01330214","article-title":"Gene-Gene and Gene-Environment\nInteractions in Apolipoprotein\nL1 Gene-Associated Nephropathy","volume":"9","author":"Freedman","year":"2014","journal-title":"Clin. J. Am.\nSoc. Nephrol."},{"issue":"9","key":"2026090409133257300_cit41","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.212779","article-title":"Children with\nSickle Cell Anemia and APOL1 Genetic Variants Develop Albuminuria\nEarly in Life","volume":"104","author":"Zahr","year":"2019","journal-title":"Haematologica"},{"issue":"6","key":"2026090409133257300_cit42","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/s41581-022-00540-9","article-title":"The Nephropathy\nof Sickle Cell Trait\nand Sickle Cell Disease","volume":"18","author":"Ataga","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"issue":"3","key":"2026090409133257300_cit43","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/S1665-2681(19)30932-9","article-title":"Association between\nButyrylcholinesterase Activity and Low-Grade Systemic Inflammation","volume":"11","author":"Lampo\u0301n","year":"2012","journal-title":"Ann. Hepatol."},{"issue":"1","key":"2026090409133257300_cit44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.7869\/tg.158","article-title":"Serum Cholinesterase\nIs an Excellent Biomarker of Liver Cirrhosis","volume":"35","author":"Ramachandran","year":"2014","journal-title":"Trop. Gastroenterol."},{"issue":"1","key":"2026090409133257300_cit45","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/jcph.1297","article-title":"Pharmacoproteomics\nProfiling of Plasma From \u03b2-Thalassemia Patients in Response\nto Hydroxyurea Treatment","volume":"59","author":"Zohaib","year":"2019","journal-title":"J. Clin. Pharmacol."},{"issue":"1","key":"2026090409133257300_cit46","doi-asserted-by":"publisher","first-page":"4908","DOI":"10.1038\/s41598-022-09022-1","article-title":"Associations of Zinc-\u03b1-2-Glycoprotein\nwith Metabolic Syndrome and Its Components among Adult Arabs","volume":"12","author":"Alenad","year":"2022","journal-title":"Sci. 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