{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:17:08Z","timestamp":1786123028985,"version":"build-2736575974"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["24444"],"award-info":[{"award-number":["24444"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Fondazione Pisa PANOMIC","doi-asserted-by":"publisher","award":["Panomic grant 2022"],"award-info":[{"award-number":["Panomic grant 2022"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pancreatic ductal adenocarcinoma remains a formidable clinical challenge, with a very poor survival rate. It is highly metastatic and quickly exhibits chemoresistance, both of which are mediated by interactions of the tumor cells with their microenvironment. Extracellular vesicles are key mediators by which tumor cells interact with their microenvironment. Here, we utilized a data-independent acquisition proteomics workflow to characterize the protein cargo of extracellular vesicles isolated from patient-derived primary cells and cell lines of varying aggressiveness. Mapping 1432 unique proteins with high reproducibility, we identified protein signatures that robustly discriminated between short-term and long-term survival phenotypes. While the data set was highly enriched for established exosomal markers, differential expression and PLS-DA modeling revealed that the most significant indicators of short survival (high aggressiveness) were ribosomal proteins. STRING analysis confirmed these as highly connected interactome hubs. These findings suggest that the differential loading of translational machinery into the extracellular space\u2500likely via microvesicles or coisolated nonvesicular particles\u2500contributes to poor prognosis, offering new insights into the systemic secretome of aggressive tumors.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00168","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:25:57Z","timestamp":1784215557000},"page":"4202-4211","source":"Crossref","is-referenced-by-count":0,"title":["Proteomics of\nExtracellular Vesicles Derived from\nPrimary Cells of Pancreatic Ductal Adenocarcinoma Patients Identifies\nRibosomal Proteins Associated with Survival"],"prefix":"10.1021","volume":"25","author":[{"given":"Asia","family":"Botto","sequence":"first","affiliation":[{"name":"Fondazione Pisana per la Scienza ONLUS , ,","place":["San Giuliano Terme (PI), Italy, 56017"]},{"name":"University of Pisa , , ,","place":["Pisa, Italy, 56124"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Ndimurwanko","sequence":"additional","affiliation":[{"name":"Fondazione Pisana per la Scienza ONLUS , ,","place":["San Giuliano Terme (PI), Italy, 56017"]},{"name":"Scuola Normale Superiore , ,","place":["Pisa, Italy, 56126"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Finamore","sequence":"additional","affiliation":[{"name":"Fondazione Pisana per la Scienza ONLUS , ,","place":["San Giuliano Terme (PI), Italy, 56017"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Comandatore","sequence":"additional","affiliation":[{"name":"VU University , , ,","place":["HV Amsterdam, The Netherlands, 1081"]},{"name":"University of Pisa , , ,","place":["Pisa, Italy, 56126"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Morelli","sequence":"additional","affiliation":[{"name":"University of Pisa , , ,","place":["Pisa, Italy, 56126"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Giovannetti","sequence":"additional","affiliation":[{"name":"Fondazione Pisana per la Scienza ONLUS , ,","place":["San Giuliano Terme (PI), Italy, 56017"]},{"name":"VU University , , ,","place":["HV Amsterdam, The Netherlands, 1081"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0595-9491","authenticated-orcid":true,"given":"Liam A.","family":"McDonnell","sequence":"additional","affiliation":[{"name":"Fondazione Pisana per la Scienza ONLUS , ,","place":["San Giuliano Terme (PI), Italy, 56017"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"2026080709085124300_cit1","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","article-title":"Pancreatic cancer","volume":"395","author":"Mizrahi","year":"2020","journal-title":"Lancet"},{"key":"2026080709085124300_cit2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.semcancer.2017.04.006","article-title":"Never let\nit go: Stopping key mechanisms underlying\nmetastasis to fight pancreatic cancer","volume":"44","author":"Giovannetti","year":"2017","journal-title":"Semin.\nCancer Biol."},{"key":"2026080709085124300_cit3","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.4708","article-title":"Estimated Projection\nof US Cancer Incidence and Death to 2040","volume":"4","author":"Rahib","year":"2021","journal-title":"JAMA\nNetw. Open"},{"key":"2026080709085124300_cit4","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1016\/S1470-2045(19)30456-5","article-title":"Progress in cancer survival,\nmortality, and incidence in seven high-income countries 1995\u20132014\n(ICBP SURVMARK-2): a population-based study","volume":"20","author":"Arnold","year":"2019","journal-title":"Lancet Oncol."},{"key":"2026080709085124300_cit5","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.pharmthera.2015.08.006","article-title":"State of the art and future directions of pancreatic\nductal adenocarcinoma therapy","volume":"155","author":"Neuzillet","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"2026080709085124300_cit6","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/j.dld.2018.08.008","article-title":"Pancreatic cancer: French\nclinical practice guidelines for diagnosis, treatment and follow-up\n(SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, ACHBT, AFC)","volume":"50","author":"Neuzillet","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"2026080709085124300_cit7","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s13014-019-1345-6","article-title":"Pancreatic ductal adenocarcinoma:\nbiological hallmarks, current status, and future perspectives of combined\nmodality treatment approaches","volume":"14","author":"Orth","year":"2019","journal-title":"Radiat. Oncol."},{"key":"2026080709085124300_cit8","doi-asserted-by":"publisher","first-page":"403","DOI":"10.18632\/oncotarget.28597","article-title":"Targeting ABC\ntransporters in PDAC\n- past, present, or future?","volume":"15","author":"Bergonzini","year":"2024","journal-title":"Oncotarget"},{"key":"2026080709085124300_cit9","doi-asserted-by":"publisher","first-page":"6844","DOI":"10.3748\/wjg.v27.i40.6844","article-title":"Role of\nhuman nucleoside transporters\nin pancreatic cancer and chemoresistance","volume":"27","author":"Carter","year":"2021","journal-title":"World\nJ. Gastroenterol."},{"key":"2026080709085124300_cit10","doi-asserted-by":"publisher","first-page":"5723","DOI":"10.1158\/0008-5472.CAN-19-0960","article-title":"Deoxycytidine Release\nfrom Pancreatic Stellate Cells Promotes Gemcitabine Resistance","volume":"79","author":"Dalin","year":"2019","journal-title":"Cancer Res."},{"key":"2026080709085124300_cit11","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.3390\/cancers14102486","article-title":"Resistance\nto Gemcitabine\nin Pancreatic Ductal Adenocarcinoma: A Physiopathologic and Pharmacologic\nReview","volume":"14","author":"Koltai","year":"2022","journal-title":"Cancers (Basel)"},{"key":"2026080709085124300_cit12","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.semcancer.2024.09.002","article-title":"Unravelling the complexities\nof resistance mechanism in pancreatic cancer: Insights from in vitro\nand ex-vivo model systems","volume":"106\u2013107","author":"Lencioni","year":"2024","journal-title":"Semin. Cancer Biol."},{"key":"2026080709085124300_cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2018.e01055","article-title":"Pancreatic\ncancer chemo-resistance\nis driven by tumor phenotype rather than tumor genotype","volume":"4","author":"Swayden","year":"2018","journal-title":"Heliyon"},{"key":"2026080709085124300_cit14","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1136\/gutjnl-2021-324994","article-title":"Extracellular Vesicles\nfrom Pancreatic Cancer Stem Cells Lead an Intratumor Communication\nNetwork (EVNet) to fuel tumour progression","volume":"71","author":"Ruivo","year":"2022","journal-title":"Gut"},{"key":"2026080709085124300_cit15","doi-asserted-by":"publisher","first-page":"286","DOI":"10.3390\/diagnostics12020286","article-title":"Potential Role of Exosomes\nin the Chemoresistance to Gemcitabine and Nab-Paclitaxel in Pancreatic\nCancer","volume":"12","author":"Comandatore","year":"2022","journal-title":"Diagnostics"},{"key":"2026080709085124300_cit16","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/ncb3169","article-title":"Pancreatic cancer exosomes\ninitiate pre-metastatic niche formation in the liver","volume":"17","author":"Costa-Silva","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"2026080709085124300_cit17","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s12951-022-01382-0","article-title":"Extracellular\nvesicle-mediated crosstalk between pancreatic cancer and stromal cells\nin the tumor microenvironment","volume":"20","author":"Li","year":"2022","journal-title":"J. Nanobiotechnology"},{"key":"2026080709085124300_cit18","doi-asserted-by":"publisher","first-page":"218411","DOI":"10.1016\/j.canlet.2026.218411","article-title":"A MUC1-ALIX\ncomplex\nregulates extracellular vesicle cargo loading with activated SRC to\nenhance pancreatic cancer progression","volume":"646","author":"Huang","year":"2026","journal-title":"Cancer\nLett."},{"key":"2026080709085124300_cit19","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/j.ymthe.2025.01.023","article-title":"Pancreatic\ncancer-derived extracellular vesicles enhance chemoresistance by delivering\nKRAS(G12D) protein to cancer-associated fibroblasts","volume":"33","author":"Liu","year":"2025","journal-title":"Mol. Ther."},{"key":"2026080709085124300_cit20","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1002\/1878-0261.13442","article-title":"Pancreatic\ncancer-derived small extracellular\nvesical ezrin activates fibroblasts to exacerbate cancer metastasis\nthrough STAT3 and YAP-1 signaling pathways","volume":"17","author":"Chang","year":"2023","journal-title":"Mol. Oncol."},{"key":"2026080709085124300_cit21","doi-asserted-by":"publisher","DOI":"10.1172\/jci157644","article-title":"KRAS mutant-driven\nSUMOylation controls extracellular vesicle transmission to trigger\nlymphangiogenesis in pancreatic cancer","volume":"132","author":"Luo","year":"2022","journal-title":"J. Clin.\nInvest."},{"key":"2026080709085124300_cit22","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12943-025-02385-9","article-title":"CircERC1\nfacilitates chemoresistance through inhibiting pyroptosis and remodeling\nextracellular matrix in pancreatic cancer","volume":"24","author":"Zhang","year":"2025","journal-title":"Mol.\nCancer"},{"key":"2026080709085124300_cit23","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1038\/onc.2016.353","article-title":"Cancer-associated fibroblast\nexosomes regulate survival and proliferation\nof pancreatic cancer cells","volume":"36","author":"Richards","year":"2017","journal-title":"Oncogene"},{"key":"2026080709085124300_cit24","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/ncb2000","article-title":"Rab27a\nand Rab27b control\ndifferent steps of the exosome secretion pathway","volume":"12","author":"Ostrowski","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"2026080709085124300_cit25","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.21037\/tcr-24-54","article-title":"Construction\nof a prognostic model with exosome biogenesis-\nand release-related genes and identification of RAB27B in immune infiltration\nof pancreatic cancer","volume":"13","author":"Li","year":"2024","journal-title":"Transl. Cancer Res."},{"key":"2026080709085124300_cit26","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3233\/CBM-220460","article-title":"RAB27B expression in pancreatic cancer is predictive\nof poor survival but good response to chemotherapy","volume":"37","author":"Pecqueux","year":"2023","journal-title":"Cancer Biomark"},{"key":"2026080709085124300_cit27","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1097\/MPA.0000000000000910","article-title":"Effects of Rab27A and\nRab27B on Invasion, Proliferation, Apoptosis, and Chemoresistance\nin Human Pancreatic Cancer Cells","volume":"46","author":"Li","year":"2017","journal-title":"Pancreas"},{"key":"2026080709085124300_cit28","doi-asserted-by":"publisher","first-page":"111543","DOI":"10.1016\/j.yexcr.2019.111543","article-title":"Exosomal miRNA-106b from cancer-associated\nfibroblast promotes gemcitabine resistance in pancreatic cancer","volume":"383","author":"Fang","year":"2019","journal-title":"Exp. Cell Res."},{"key":"2026080709085124300_cit29","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/s41419-021-04258-7","article-title":"Extracellular vesicles\nin pancreatic cancer progression\nand therapies","volume":"12","author":"Chang","year":"2021","journal-title":"Cell Death Dis."},{"key":"2026080709085124300_cit30","doi-asserted-by":"publisher","first-page":"966661","DOI":"10.3389\/fimmu.2022.966661","article-title":"Delineating the role\nof extracellular\nvesicles in cancer metastasis: A comprehensive review","volume":"13","author":"Majood","year":"2022","journal-title":"Front. Immunol."},{"key":"2026080709085124300_cit31","doi-asserted-by":"publisher","first-page":"29","DOI":"10.21037\/tgh-23-53","article-title":"Extracellular\nvesicles in pancreatic\ncancer: a new era in precision medicine","volume":"9","author":"Panda","year":"2024","journal-title":"Transl.\nGastroenterol. Hepatol."},{"key":"2026080709085124300_cit32","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/bf00133561","article-title":"Correlation\nbetween spontaneous metastatic\npotential and type I collagenolytic activity in a human pancreatic\ncancer cell line (SUIT-2) and sublines","volume":"10","author":"Taniguchi","year":"1992","journal-title":"Clin.\nExp. Metastasis"},{"key":"2026080709085124300_cit33","doi-asserted-by":"publisher","first-page":"44686","DOI":"10.1038\/srep44686","article-title":"Development\nof bioluminescent chick chorioallantoic membrane (CAM) models for\nprimary pancreatic cancer cells: a platform for drug testing","volume":"7","author":"Rovithi","year":"2017","journal-title":"Sci. Rep."},{"key":"2026080709085124300_cit34","doi-asserted-by":"publisher","first-page":"20498","DOI":"10.1038\/s41598-020-77535-8","article-title":"Proteomics\nanalysis of serum small extracellular vesicles\nfor the longitudinal study of a glioblastoma multiforme mouse model","volume":"10","author":"Anastasi","year":"2020","journal-title":"Sci. Rep."},{"key":"2026080709085124300_cit35","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1021\/acs.jproteome.5c00082","article-title":"Novel PPT+SEC Workflow\nfor High-Sensitivity Extracellular Vesicle Proteomics from Cell Media","volume":"24","author":"Botto","year":"2025","journal-title":"J. Proteome Res."},{"key":"2026080709085124300_cit36","doi-asserted-by":"publisher","first-page":"4722","DOI":"10.1021\/acs.jproteome.6b00889","article-title":"Set of\nNovel Automated Quantitative Microproteomics Protocols for Small Sample\nAmounts and Its Application to Kidney Tissue Substructures","volume":"15","author":"de Graaf","year":"2016","journal-title":"J. Proteome Res."},{"key":"2026080709085124300_cit37","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.jmb.2015.09.019","article-title":"ExoCarta: A Web-Based\nCompendium of Exosomal Cargo","volume":"428","author":"Keerthikumar","year":"2016","journal-title":"J. Mol. Biol."},{"key":"2026080709085124300_cit38","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1136\/gutjnl-2020-323014","article-title":"Exosome-delivered CD44v6\/C1QBP complex drives\npancreatic cancer liver metastasis by promoting fibrotic liver microenvironment","volume":"71","author":"Xie","year":"2022","journal-title":"Gut"},{"key":"2026080709085124300_cit39","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.canlet.2021.03.010","article-title":"Exosomal integrins\nand their influence on pancreatic cancer progression and metastasis","volume":"507","author":"Casari","year":"2021","journal-title":"Cancer Lett."},{"key":"2026080709085124300_cit40","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/proteomes7020014","article-title":"Extracellular Vesicle Integrins Distinguish\nUnique Cancers","volume":"7","author":"Hurwitz","year":"2019","journal-title":"Proteomes"},{"key":"2026080709085124300_cit41","doi-asserted-by":"publisher","first-page":"010447","DOI":"10.1074\/mcp.m111.010447","article-title":"ApoptoProteomics, an\nintegrated database for analysis\nof proteomics data obtained from apoptotic cells","volume":"11","author":"Arntzen","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"2026080709085124300_cit42","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.3390\/ijms22062951","article-title":"Proteomics Profiling of Neuron-Derived\nSmall Extracellular\nVesicles from Human Plasma: Enabling Single-Subject Analysis","volume":"22","author":"Anastasi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026080709085124300_cit43","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12404","article-title":"Minimal information\nfor studies of extracellular vesicles (MISEV2023): From basic to advanced\napproaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"2026080709085124300_cit44","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1021\/acs.jproteome.8b00647","article-title":"Quantitative Proteomic Analysis of Small and Large\nExtracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins\nin Small EVs","volume":"18","author":"Jimenez","year":"2019","journal-title":"J. Proteome Res."},{"key":"2026080709085124300_cit45","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.1021\/acs.jproteome.5c00149","article-title":"Comprehensive Comparison of Methods\nfor Isolation of Extracellular\nVesicles from Human Plasma","volume":"24","author":"Suresh","year":"2025","journal-title":"J. Proteome Res."},{"key":"2026080709085124300_cit46","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.70142","article-title":"Assessment of Vault\nParticles in Cancer Cell Line-Derived Extracellular Vesicle Preparations","volume":"14","author":"Liu","year":"2025","journal-title":"J. Extracell. Vesicles"},{"key":"2026080709085124300_cit47","doi-asserted-by":"publisher","first-page":"7071","DOI":"10.2147\/IJN.S325448","article-title":"Roles of Microvesicles\nin Tumor Progression and Clinical Applications","volume":"16","author":"Zhu","year":"2021","journal-title":"Int. J. Nanomedicine"},{"key":"2026080709085124300_cit48","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12318","article-title":"The glycoprotein\nCD147 defines miRNA-enriched extracellular vesicles that derive from\ncancer cells","volume":"12","author":"Ko","year":"2023","journal-title":"J. Extracell. Vesicles"},{"key":"2026080709085124300_cit49","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1002\/cbin.11040","article-title":"Heterogeneity of microvesicles from cancer cell lines under inflammatory\nstimulation with TNF-\u03b1","volume":"42","author":"Gieseler","year":"2018","journal-title":"Cell Biol. Int."},{"key":"2026080709085124300_cit50","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.3390\/ijms26041562","article-title":"Vault Particles in Cancer Progression,\nMultidrug Resistance, and Drug Delivery: Current Insights and Future\nApplications","volume":"26","author":"Maniatis","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"2026080709085124300_cit51","doi-asserted-by":"publisher","first-page":"1399222","DOI":"10.3389\/fimmu.2024.1399222","article-title":"Unraveling\nthe role of Major Vault Protein as a novel immune-related biomarker\nthat promotes the proliferation and migration in pancreatic adenocarcinoma","volume":"15","author":"Wu","year":"2024","journal-title":"Front. Immunol."},{"key":"2026080709085124300_cit52","doi-asserted-by":"publisher","first-page":"6319685","DOI":"10.1155\/2022\/6319685","article-title":"hnRNPC Promotes\nMalignancy in Pancreatic Cancer through Stabilization of IQGAP3","volume":"2022","author":"Yang","year":"2022","journal-title":"BioMed Res. Int."},{"key":"2026080709085124300_cit53","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.bbrc.2021.09.052","article-title":"Effects of ribosomal\nassociated protein hnRNP D in gemcitabine-resistant\npancreatic cancer","volume":"579","author":"Wang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026080709085124300_cit54","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1007\/s12015-026-11066-z","article-title":"HNRNPF Increases\nMAF and CCNB2 Levels To Promote Cancer Cell Stemness and Progression\nof Pancreatic Ductal Adenocarcinoma","volume":"22","author":"Dong","year":"2026","journal-title":"Stem Cell\nRev. Rep."},{"key":"2026080709085124300_cit55","doi-asserted-by":"publisher","first-page":"5195","DOI":"10.1038\/s41467-023-40798-6","article-title":"A super-enhancer-regulated\nRNA-binding protein cascade\ndrives pancreatic cancer","volume":"14","author":"Antal","year":"2023","journal-title":"Nat. Commun."},{"key":"2026080709085124300_cit56","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1002\/ijc.24744","article-title":"Increased expression of the heterogeneous nuclear ribonucleoprotein\nK in pancreatic cancer and its association with the mutant p53","volume":"126","author":"Zhou","year":"2010","journal-title":"Int. J. Cancer"},{"key":"2026080709085124300_cit57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/5134050","article-title":"Identification of Upregulated\nHNRNPs Associated with Poor Prognosis\nin Pancreatic Cancer","volume":"2019","author":"Qiao","year":"2019","journal-title":"BioMed Res. 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