{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:14:51Z","timestamp":1786122891902,"version":"build-2736575974"},"reference-count":78,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["KCXFZ20211020163408012"],"award-info":[{"award-number":["KCXFZ20211020163408012"]}],"id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62103397"],"award-info":[{"award-number":["62103397"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017607","name":"Shenzhen Municipal Fundamental Research Program","doi-asserted-by":"publisher","award":["JCYJ20220818102811024"],"award-info":[{"award-number":["JCYJ20220818102811024"]}],"id":[{"id":"10.13039\/501100017607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Shenzhen High-level Hospital Construction Fund","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Amnestic mild cognitive impairment (aMCI) is often considered an early clinical stage of Alzheimer\u2019s disease (AD), but its subtle presentation leads to infrequent neurological evaluations. Early plasma biomarker screening during routine check-ups in community hospitals could enhance aMCI detection rates. Advances in proteomics, particularly mass spectrometry, have enabled the detection of low-abundance plasma proteins, opening new possibilities for aMCI biomarker identification. This study included 84 participants from the STAR cohort. We utilized deep plasma proteomics to detect low-abundance proteins, enriched with nanoparticle magnetic beads. An early diagnostic model for aMCI was developed through bioinformatics and machine learning, with performance compared to the Simoa assay. We identified 4268 low-abundance plasma proteins and constructed a 12-protein diagnostic panel (AUC = 0.992 in the training set, AUC = 0.933 in the testing set), outperforming the Simoa assay (accuracy: 93.9% vs 24.4%). In conclusion, the 12-protein panel provides a cost-effective method for early aMCI detection, potentially improving screening efficacy.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00231","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:11:04Z","timestamp":1783451464000},"page":"4237-4250","source":"Crossref","is-referenced-by-count":0,"title":["Deep Plasma\nProteomics-Based Diagnostic Panel for\nEarly Detection of Amnestic Mild Cognitive Impairment"],"prefix":"10.1021","volume":"25","author":[{"given":"Hui","family":"Shan","sequence":"first","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3734-8800","authenticated-orcid":true,"given":"Gaigai","family":"Lu","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-0696","authenticated-orcid":true,"given":"Yuyao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Peking University Health Science Center , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongye","family":"Dong","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongzhou","family":"Fang","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuonan","family":"Wei","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Hu","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wu","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silin","family":"Tao","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchen","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Luo","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Qi","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hu","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanxun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Fan","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Yin","sequence":"additional","affiliation":[{"name":"Peking University Shenzhen Hospital , , ,","place":["Shenzhen, China, 518036"]},{"name":"Peking University Health Science Center , , ,","place":["Beijing, China, 100191"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"2026080709075491400_cit1","doi-asserted-by":"publisher","first-page":"3708","DOI":"10.1002\/alz.13809","article-title":"2024 Alzheimer\u2019s\nDisease Facts and Figures","volume":"20","author":"Alzheimer\u2019s Association.","year":"2024","journal-title":"Alzheimer\u2019s\nDementia"},{"key":"2026080709075491400_cit2","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12385","article-title":"Alzheimer\u2019s\nDisease Drug Development Pipeline: 2023","volume":"9","author":"Cummings","year":"2023","journal-title":"Alzheimer\u2019s\nDementia"},{"key":"2026080709075491400_cit3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"Alzheimers\nDement NIA-AA Research Framework: Toward a Biological Definition of\nAlzheimer\u2019s Disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer\u2019s\nDementia"},{"key":"2026080709075491400_cit4","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised Criteria for Diagnosis and Staging of Alzheimer\u2019s\nDisease: Alzheimer\u2019s Association Workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2026080709075491400_cit5","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2022-100751","article-title":"The China\nAlzheimer Report 2022","volume":"35","author":"Ren","year":"2022","journal-title":"Gen. Psychiatry"},{"key":"2026080709075491400_cit6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147907","article-title":"Prognosis of Alzheimer\u2019s Disease\nUsing Quantitative Mass Spectrometry of Human Blood Plasma Proteins\nand Machine Learning","volume":"23","author":"Kononikhin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026080709075491400_cit7","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1038\/s41591-025-03565-2","article-title":"A Cerebrospinal\nFluid Synaptic Protein Biomarker for\nPrediction of Cognitive Resilience versus Decline in Alzheimer\u2019s\nDisease","volume":"31","author":"Oh","year":"2025","journal-title":"Nat. Med."},{"key":"2026080709075491400_cit8","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01578-6","article-title":"Multi-Omics\nAnalysis Reveals the Key Factors Involved\nin the Severity of the Alzheimer\u2019s Disease","volume":"16","author":"Meng","year":"2024","journal-title":"Alzheimer\u2019s Res. Ther"},{"key":"2026080709075491400_cit9","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70900","article-title":"Longitudinal Plasma Proteomics: Relation to Incident Alzheimer\u2019s\nDisease Dementia and Biomarkers","volume":"21","author":"Lee","year":"2025","journal-title":"Alzheimer\u2019s\nDementia"},{"key":"2026080709075491400_cit10","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70851","article-title":"Plasma Proteomic Alzheimer\u2019s\nRisk Score: Biological Age Clock and Pseudotime Trajectory","volume":"21","author":"Liu","year":"2025","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2026080709075491400_cit11","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70579","article-title":"Plasma Proteomic Analysis Identifies\nProteins and Pathways Related to Alzheimer\u2019s Risk","volume":"21","author":"Huang","year":"2025","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2026080709075491400_cit12","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70505","article-title":"Novel Set of Plasma Proteins Classifies Alzheimer\u2019s\nDementia in African American Individuals with High Accuracy","volume":"21","author":"Kuchenbecker","year":"2025","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2026080709075491400_cit13","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.818141","article-title":"Discovering New Peripheral Plasma Biomarkers to Identify\nCognitive Decline in Type 2 Diabetes","volume":"10","author":"Yu","year":"2022","journal-title":"Front.\nCell Dev. Biol."},{"key":"2026080709075491400_cit14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098117","article-title":"Blood-Based Proteomic\nProfiling Identifies Potential Biomarker Candidates and Pathogenic\nPathways in Dementia","volume":"24","author":"Ehtewish","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2026080709075491400_cit15","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70276","article-title":"LC-MS\/MS\nProteomics Identifies Plasma Proteins Related to Cognition over 9-Year\nFollow-Up","volume":"21","author":"Adegboye","year":"2025","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2026080709075491400_cit16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s43587-023-00550-7","article-title":"Cerebrospinal Fluid\nProteomics in Patients with Alzheimer\u2019s Disease Reveals Five\nMolecular Subtypes with Distinct Genetic Risk Profiles","volume":"4","author":"Tijms","year":"2024","journal-title":"Nat. Aging"},{"key":"2026080709075491400_cit17","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.1002\/alz.13821","article-title":"Proteomic\nChanges in the Human Cerebrovasculature in Alzheimer\u2019s Disease\nand Related Tauopathies Linked to Peripheral Biomarkers in Plasma\nand Cerebrospinal Fluid","volume":"20","author":"Wojtas","year":"2024","journal-title":"Alzheimer\u2019s\nDementia"},{"key":"2026080709075491400_cit18","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70051","article-title":"CSF Proteomics Reveals Changes in\nMyelin and Synaptic Biology after Spectris Treatment","volume":"11","author":"Hajo\u0301s","year":"2025","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2026080709075491400_cit19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nature19949","article-title":"Mass-Spectrometric Exploration of Proteome Structure and Function","volume":"537","author":"Aebersold","year":"2016","journal-title":"Nature"},{"key":"2026080709075491400_cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2024.100721","article-title":"Alzheimer\u2019s\nDisease Biomarker Analysis Using Targeted Mass Spectrometry","volume":"23","author":"Gobom","year":"2024","journal-title":"Mol. Cell Proteomics"},{"key":"2026080709075491400_cit21","doi-asserted-by":"publisher","first-page":"4085","DOI":"10.1021\/acs.jproteome.9b00503","article-title":"Mass Spectrometry-Based\nPlasma Proteomics: Considerations from Sample Collection to Achieving\nTranslational Data","volume":"18","author":"Ignjatovic","year":"2019","journal-title":"J. Proteome Res."},{"key":"2026080709075491400_cit22","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1177\/0022034510380414","article-title":"Comparative Human Salivary and Plasma\nProteomes","volume":"89","author":"Loo","year":"2010","journal-title":"J. Dent. Res."},{"key":"2026080709075491400_cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2025.101003","article-title":"Recent Advances in Mass Spectrometry-Based\nStudies of Post-Translational Modifications in Alzheimer\u2019s\nDisease","volume":"24","author":"Wu","year":"2025","journal-title":"Mol. Cell Proteomics"},{"key":"2026080709075491400_cit24","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1007\/s40120-024-00658-x","article-title":"Navigating\nthe Landscape of Plasma Biomarkers in Alzheimer\u2019s Disease:\nFocus on Past, Present, and Future Clinical Applications","volume":"13","author":"Ankeny","year":"2024","journal-title":"Neurol. Ther."},{"key":"2026080709075491400_cit25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17033-7","article-title":"Rapid, Deep and Precise Profiling\nof the Plasma Proteome\nwith Multi-Nanoparticle Protein Corona","volume":"11","author":"Blume","year":"2020","journal-title":"Nat.\nCommun."},{"key":"2026080709075491400_cit26","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1038\/s41591-023-02476-4","article-title":"Cerebrospinal Fluid Proteomics Define the Natural History\nof Autosomal Dominant Alzheimer\u2019s Disease","volume":"29","author":"Johnson","year":"2023","journal-title":"Nat. Med."},{"key":"2026080709075491400_cit27","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27010015","article-title":"Plasma Protein Panel for Assessing\nthe Risk of Alzheimer\u2019s Disease by MRM-MS Analysis: The Study\nof Two Independent Clinical Cohorts","volume":"27","author":"Strelnikova","year":"2026","journal-title":"Int. J.\nMol. Sci."},{"key":"2026080709075491400_cit28","doi-asserted-by":"publisher","first-page":"4270","DOI":"10.1021\/acs.jproteome.5c00513","article-title":"Plasma Proteomic\nAnalysis for Alzheimer\u2019s Disease Biomarkers, Pathways, and\nSubgroup Identification","volume":"24","author":"Pen\u0303a-Bautista","year":"2025","journal-title":"J. Proteome Res."},{"key":"2026080709075491400_cit29","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The Diagnosis of\nMild Cognitive Impairment Due to Alzheimer\u2019s\nDisease: Recommendations from the National Institute on Aging-Alzheimer\u2019s\nAssociation Workgroups on Diagnostic Guidelines for Alzheimer\u2019s\nDisease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2026080709075491400_cit30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2796.2004.01388.x","article-title":"Mild Cognitive\nImpairment as a Diagnostic Entity","volume":"256","author":"Petersen","year":"2004","journal-title":"J. Int. Med."},{"key":"2026080709075491400_cit31","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1136\/jnnp-2024-333467","article-title":"BALTAZAR study group.\nClinical Value of Plasma ALZpath pTau217 Immunoassay for Assessing\nMild Cognitive Impairment","volume":"95","author":"Lehmann","year":"2024","journal-title":"J. Neurol. Neurosurg.\nPsychiatry"},{"key":"2026080709075491400_cit32","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1001\/jamaneurol.2023.5319","article-title":"Diagnostic\nAccuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer\nDisease Pathology","volume":"81","author":"Ashton","year":"2024","journal-title":"JAMA Neurol."},{"key":"2026080709075491400_cit33","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01458-z","article-title":"Pathophysiology Characterization of Alzheimer\u2019s\nDisease in South China\u2019s Aging Population: For the Greater-Bay-Area\nHealthy Aging Brain Study (GHABS)","volume":"16","author":"Liu","year":"2024","journal-title":"Alzheimer\u2019s\nRes. Ther."},{"key":"2026080709075491400_cit34","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1016\/j.immuni.2022.10.016","article-title":"Emerging Roles of\nInnate and Adaptive Immunity in Alzheimer\u2019s\nDisease","volume":"55","author":"Chen","year":"2022","journal-title":"Immunity"},{"key":"2026080709075491400_cit35","doi-asserted-by":"publisher","DOI":"10.3390\/cells11121885","article-title":"Innate\nImmune Cell Death in Neuroinflammation and Alzheimer\u2019s\nDisease","volume":"11","author":"Rajesh","year":"2022","journal-title":"Cells"},{"key":"2026080709075491400_cit36","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s Disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"2026080709075491400_cit37","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/alz.12683","article-title":"The Role\nof Mitochondrial Dysfunction\nin Alzheimer\u2019s Disease Pathogenesis","volume":"19","author":"Ashleigh","year":"2023","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2026080709075491400_cit38","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3233\/JAD-170585","article-title":"Mitochondria\nand Mitochondrial Cascades in Alzheimer\u2019s Disease","volume":"62","author":"Swerdlow","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"2026080709075491400_cit39","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02613-9","article-title":"Mitochondrial Dysfunction in Microglia:\nA Novel Perspective for Pathogenesis of Alzheimer\u2019s Disease","volume":"19","author":"Li","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"2026080709075491400_cit40","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/s41593-023-01257-z","article-title":"Perivascular Cells Induce Microglial\nPhagocytic States and Synaptic Engulfment via SPP1 in Mouse Models\nof Alzheimer\u2019s Disease","volume":"26","author":"De Schepper","year":"2023","journal-title":"Nat. Neurosci."},{"key":"2026080709075491400_cit41","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement\nand Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"2026080709075491400_cit42","doi-asserted-by":"publisher","first-page":"p2111","DOI":"10.1016\/j.celrep.2019.07.060","article-title":"Complement\nC3 Is Activated in Human AD Brain and Is Required for Neurodegeneration\nin Mouse Models of Amyloidosis and Tauopathy","volume":"28","author":"Wu","year":"2019","journal-title":"Cell Rep."},{"key":"2026080709075491400_cit43","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.neuron.2018.10.031","article-title":"Complement C3aR Inactivation\nAttenuates Tau Pathology and Reverses\nan Immune Network Deregulated in Tauopathy Models and Alzheimer\u2019s\nDisease","volume":"100","author":"Litvinchuk","year":"2018","journal-title":"Neuron"},{"key":"2026080709075491400_cit44","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/glia.23760","article-title":"mTOR-Mediated Metabolic\nReprogramming Shapes Distinct Microglia Functions in Response to Lipopolysaccharide\nand ATP","volume":"68","author":"Hu","year":"2020","journal-title":"Glia"},{"key":"2026080709075491400_cit45","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.cmet.2022.02.013","article-title":"Positive Feedback Regulation\nof Microglial Glucose\nMetabolism by Histone H4 Lysine 12 Lactylation in Alzheimer\u2019s\nDisease","volume":"34","author":"Pan","year":"2022","journal-title":"Cell Metab."},{"key":"2026080709075491400_cit46","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1111\/bpa.12704","article-title":"Iron Accumulation\nin Microglia Triggers\na Cascade of Events That Leads to Altered Metabolism and Compromised\nFunction in APP\/PS1Mice","volume":"29","author":"McIntosh","year":"2019","journal-title":"Brain Pathol."},{"key":"2026080709075491400_cit47","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.1016\/j.neuron.2023.07.005","article-title":"Neuronal\n\u03b3-Secretase Regulates Lipid Metabolism,\nLinking Cholesterol to Synaptic Dysfunction in Alzheimer\u2019s\nDisease","volume":"111","author":"Essayan-Perez","year":"2023","journal-title":"Neuron"},{"key":"2026080709075491400_cit48","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1111\/febs.16344","article-title":"Lipid Metabolism\nand Alzheimer\u2019s Disease: Clinical Evidence, Mechanistic Link\nand Therapeutic Promise","volume":"290","author":"Yin","year":"2023","journal-title":"FEBS J."},{"key":"2026080709075491400_cit49","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41586-024-07185-7","article-title":"APOE4\/4 Is\nLinked to Damaging Lipid Droplets in Alzheimer\u2019s Disease Microglia","volume":"628","author":"Haney","year":"2024","journal-title":"Nature"},{"key":"2026080709075491400_cit50","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26195979","article-title":"Detection\nof Circulating Serum microRNA\/Protein Complexes in ASD Using Functionalized\nChips for an Atomic Force Microscope","volume":"26","author":"Kaysheva","year":"2021","journal-title":"Molecules"},{"key":"2026080709075491400_cit51","doi-asserted-by":"publisher","DOI":"10.3390\/genes12101507","article-title":"Neuroplastin in Neuropsychiatric\nDiseases","volume":"12","author":"Lin","year":"2021","journal-title":"Genes"},{"key":"2026080709075491400_cit52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035785","article-title":"Kidins220\/ARMS Is a Novel Modulator of Short-Term Synaptic\nPlasticity in Hippocampal GABAergic Neurons","volume":"7","author":"Scholz-Starke","year":"2012","journal-title":"PLoS One"},{"key":"2026080709075491400_cit53","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1096\/fj.11-202853","article-title":"Thioesterase\nSuperfamily Member 2\/Acyl-CoA Thioesterase 13 (Them2\/Acot13) Regulates\nHepatic Lipid and Glucose Metabolism","volume":"26","author":"Kang","year":"2012","journal-title":"FASEB\nJ."},{"key":"2026080709075491400_cit54","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/0014-5793(91)80886-8","article-title":"Electron Transfer Properties of NADH:Ubiquinone Reductase\nin the ND1\/3460 and the ND4\/11778 Mutations of the Leber Hereditary\nOptic Neuroretinopathy (LHON)","volume":"292","author":"Majander","year":"1991","journal-title":"FEBS Lett."},{"key":"2026080709075491400_cit55","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1074\/jbc.273.1.329","article-title":"Characterization of a Fungal Maleylacetoacetate Isomerase\nGene and Identification of Its Human Homologue","volume":"273","author":"Ferna\u0301ndez-Can\u0303o\u0301n","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2026080709075491400_cit56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20796-8","article-title":"SVIP Is a Molecular Determinant of Lysosomal Dynamic\nStability, Neurodegeneration and Lifespan","volume":"12","author":"Johnson","year":"2021","journal-title":"Nat.\nCommun."},{"key":"2026080709075491400_cit57","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.cell.2017.07.011","article-title":"Cryo-EM Structure of\na Pre-Catalytic\nHuman Spliceosome Primed for Activation","volume":"170","author":"Bertram","year":"2017","journal-title":"Cell"},{"key":"2026080709075491400_cit58","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00688-18","article-title":"Human Cytomegalovirus\nTropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That\nGoverns Endoplasmic Reticulum-Associated Degradation of the Viral\nEnvelope Glycoprotein gO","volume":"92","author":"Nguyen","year":"2018","journal-title":"J. Virol."},{"key":"2026080709075491400_cit59","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1136\/jmedgenet-2012-101375","article-title":"Whole-Exome\nSequencing Identifies\na Mutation in the Mitochondrial Ribosome Protein MRPL44 to Underlie\nMitochondrial Infantile Cardiomyopathy","volume":"50","author":"Carroll","year":"2013","journal-title":"J. Med.\nGenet."},{"key":"2026080709075491400_cit60","doi-asserted-by":"publisher","DOI":"10.1186\/s41065-022-00252-x","article-title":"Bioinformatics Analysis of Diagnostic\nBiomarkers for Alzheimer\u2019s Disease in Peripheral Blood Based\non Sex Differences and Support Vector Machine Algorithm","volume":"159","author":"Ji","year":"2022","journal-title":"Hereditas"},{"key":"2026080709075491400_cit61","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00233","article-title":"The Predicted\nKey Molecules, Functions, and Pathways That Bridge Mild Cognitive\nImpairment (MCI) and Alzheimer\u2019s Disease (AD)","volume":"11","author":"Tao","year":"2020","journal-title":"Front. Neurol."},{"key":"2026080709075491400_cit62","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1111\/jcmm.13998","article-title":"Hippocampal Expression of Cell-Adhesion\nGlycoprotein Neuroplastin Is Altered in Alzheimer\u2019s Disease","volume":"23","author":"Ilic","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"2026080709075491400_cit63","doi-asserted-by":"publisher","DOI":"10.3390\/biology12070972","article-title":"Mitochondrial\nNeurodegenerative Diseases: Three Mitochondrial Ribosomal Proteins\nas Intermediate Stage in the Pathway That Associates Damaged Genes\nwith Alzheimer\u2019s and Parkinson\u2019s","volume":"12","author":"Del Giudice","year":"2023","journal-title":"Biology"},{"key":"2026080709075491400_cit64","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.mito.2022.02.006","article-title":"Mitochondrial\nRibosomal Protein Genes Connected with Alzheimer\u2019s and Tellurite\nToxicity","volume":"64","author":"Del Giudice","year":"2022","journal-title":"Mitochondrion"},{"key":"2026080709075491400_cit65","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1002\/alz.12319","article-title":"Whole-Genome Sequencing Reveals New Alzheimer\u2019s\nDisease-Associated Rare Variants in Loci Related to Synaptic Function\nand Neuronal Development","volume":"17","author":"Prokopenko","year":"2021","journal-title":"Alzheimer\u2019s\nDementia"},{"key":"2026080709075491400_cit66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.134466","article-title":"The Involvement\nof SigmaR1K142 Degradation Mediated\nby ERAD in Neural Senescence Linked with CdCl2 Exposure","volume":"472","author":"Qian","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"2026080709075491400_cit67","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.581882","article-title":"Mitochondrial RNA in Alzheimer\u2019s\nDisease Circulating\nExtracellular Vesicles","volume":"8","author":"Kim","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"2026080709075491400_cit68","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.neurobiolaging.2016.12.029","article-title":"Mitochondrial\nGenes Are Altered in Blood Early in Alzheimer\u2019s\nDisease","volume":"53","author":"Lunnon","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"2026080709075491400_cit69","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.3233\/JAD-160639","article-title":"Kidins220 Correlates with Tau in\nAlzheimer\u2019s Disease Brain and Cerebrospinal Fluid","volume":"55","author":"Gamir-Morralla","year":"2016","journal-title":"J. Alzheimer\u2019s Dis"},{"key":"2026080709075491400_cit70","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1093\/hmg\/dds446","article-title":"Kidins220 Accumulates with Tau in\nHuman Alzheimer\u2019s Disease and Related Models: Modulation of\nIts Calpain-Processing by GSK3\u03b2\/PP1 Imbalance","volume":"22","author":"Lo\u0301pez-Mene\u0301ndez","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"2026080709075491400_cit71","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1001\/jamaneurol.2020.4201","article-title":"Associations of Plasma Phospho-Tau217\nLevels with Tau Positron Emission Tomography in Early Alzheimer Disease","volume":"78","author":"Janelidze","year":"2021","journal-title":"JAMA Neurol."},{"key":"2026080709075491400_cit72","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1002\/alz.12724","article-title":"Plasma A\u03b242\/40 Ratio, p-Tau181,\nGFAP, and NfL\nacross the Alzheimer\u2019s Disease Continuum: A Cross-Sectional\nand Longitudinal Study in the AIBL Cohort","volume":"19","author":"Chatterjee","year":"2023","journal-title":"Alzheimer\u2019s\nDementia"},{"key":"2026080709075491400_cit73","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1002\/alz.12283","article-title":"The Diagnostic and Prognostic Capabilities of Plasma\nBiomarkers in Alzheimer\u2019s Disease","volume":"17","author":"Simre\u0301n","year":"2021","journal-title":"Alzheimer\u2019s\nDementia"},{"key":"2026080709075491400_cit74","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00682-7","article-title":"Combination of Plasma Amyloid Beta(1\u201342\/1\u201340)\nand Glial Fibrillary Acidic Protein Strongly Associates with Cerebral\nAmyloid Pathology","volume":"12","author":"Verberk","year":"2020","journal-title":"Alzheimer\u2019s Res. Ther"},{"key":"2026080709075491400_cit75","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.jalz.2019.09.004","article-title":"Plasma Biomarkers\nof Astrocytic and Neuronal Dysfunction in Early- and Late-Onset Alzheimer\u2019s\nDisease","volume":"16","author":"Elahi","year":"2020","journal-title":"Alzheimer\u2019s Dementia"},{"key":"2026080709075491400_cit76","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay8826","article-title":"Autosomal Dominant VCP Hypomorph Mutation Impairs Disaggregation\nof PHF-Tau","volume":"370","author":"Darwich","year":"2020","journal-title":"Science"},{"key":"2026080709075491400_cit77","doi-asserted-by":"publisher","first-page":"6220","DOI":"10.1093\/nar\/gkae266","article-title":"Growth-Regulated\nCo-Occupancy of Mediator and Lsm3 at Intronic Ribosomal Protein Genes","volume":"52","author":"Abdel-Fattah","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"2026080709075491400_cit78","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/cr.2013.152","article-title":"Lsm2 and Lsm3 Bridge the Interaction\nof the Lsm1\u20137 Complex with Pat1 for Decapping Activation","volume":"24","author":"Wu","year":"2014","journal-title":"Cell Res."}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.6c00231","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/8\/4237\/65812932\/acs.jproteome.6c00231.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/8\/4237\/65812932\/acs.jproteome.6c00231.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T13:20:38Z","timestamp":1786108838000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jprobs\/article\/25\/8\/4237\/5202616\/Deep-Plasma-Proteomics-Based-Diagnostic-Panel-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":78,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,7]]},"published-print":{"date-parts":[[2026,8,7]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.6c00231","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]}}}