{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:45:37Z","timestamp":1792784737904,"version":"4.5.0"},"reference-count":92,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2027,9,14]],"date-time":"2027-09-14T00:00:00Z","timestamp":1820880000000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","award":["41035"],"award-info":[{"award-number":["41035"]}],"id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009192","name":"Alberta Innovates","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009192","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Sciences and Engineering Research Council of Canada (NSERC)","award":["RGPIN-2021-02545"],"award-info":[{"award-number":["RGPIN-2021-02545"]}],"id":[{"id":"https:\/\/ror.org\/01h531d29","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The neurotransmitter dopamine (DA) is central to synaptic regulation that supports diverse behavioral functions, including both learning and forgetting. This multifunctional role of DA is due to receptor-specific signaling in specific subcellular environments that remain uncharacterized. Here we used Turbo-mediated proximity labeling in human cells to characterize the proximal environments of two Drosophila D1-like DA receptors (Dop1R1 and Dop1R2) in basal and DA-activation environments. DA drives both Dop1R1-Turbo and Dop1R2-Turbo to recruit \u03b2-arrestin 2, and Dop1R1-Turbo showed ligand-driven proximity to G-protein receptor kinase 3, members of clathrin-mediated endocytosis pathways, and WASH complex-mediated endosomal trafficking pathways. Additionally, we show evidence that Dop1R1 and Dop1R2 reside in distinct domains on the cell surface. In vivo disruption of Drosophila orthologues of Dop1R proximal proteins revealed three trafficking proteins, Sec24AB, Krz (beta-arrestin 2), and CG13887, that regulate R1-mediated learning, starvation-induced attraction to odors, and DA-mediated cAMP responses in memory circuits. In addition to revealing DA receptor trafficking proteins that support learning, our comparative characterization of the cellular environments of D1-like receptors offers insights into how DA differentially regulates diverse behavioral and synaptic functions.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00259","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:01:38Z","timestamp":1789426898000},"page":"5339-5355","source":"Crossref","is-referenced-by-count":0,"title":["Proximity\nLabeling of D1-Like Dopamine Receptors Captures\nDistinct Cellular Environments and Uncovers Trafficking Proteins That\nRegulate DA-Mediated Behaviors in\n                    <i>Drosophila<\/i>"],"prefix":"10.1021","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1640-0954","authenticated-orcid":true,"given":"Dana C.","family":"Guhle","sequence":"first","affiliation":[{"name":"University of Alberta , , 11455 Saskatchewan Drive , , ,","place":["Edmonton, Alberta, Canada, T6G 2E9"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavana","family":"Kanagala","sequence":"additional","affiliation":[{"name":"University of Alberta , , 11455 Saskatchewan Drive , , ,","place":["Edmonton, Alberta, Canada, T6G 2E9"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Dust","sequence":"additional","affiliation":[{"name":"University of Alberta , , 11455 Saskatchewan Drive , , ,","place":["Edmonton, Alberta, Canada, T6G 2E9"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Evashkevich","sequence":"additional","affiliation":[{"name":"University of Alberta , , 11455 Saskatchewan Drive , , ,","place":["Edmonton, Alberta, Canada, T6G 2E9"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L.","family":"Davis","sequence":"additional","affiliation":[{"name":"Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology , , 130 Scripps Way , , ,","place":["Jupiter, Florida, United States, 33458"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-1720","authenticated-orcid":true,"given":"Jacob A.","family":"Berry","sequence":"additional","affiliation":[{"name":"University of Alberta , , 11455 Saskatchewan Drive , , ,","place":["Edmonton, Alberta, Canada, T6G 2E9"]},{"name":"University of Alberta , , 87 Avenue & 112 Street , , ,","place":["Edmonton, Alberta, Canada, T6G 2E1"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"issue":"33","key":"2026100208422086100_cit1","doi-asserted-by":"publisher","first-page":"10495","DOI":"10.1523\/JNEUROSCI.23-33-10495.2003","article-title":"Dopamine and Octopamine Differentiate\nbetween Aversive and Appetitive Olfactory Memories in Drosophila","volume":"23","author":"Schwaerzel","year":"2003","journal-title":"J. Neurosci."},{"issue":"29","key":"2026100208422086100_cit2","doi-asserted-by":"publisher","first-page":"7640","DOI":"10.1523\/JNEUROSCI.1167-07.2007","article-title":"D1 Dopamine\nReceptor dDA1 Is Required\nin the Mushroom Body Neurons for Aversive and Appetitive Learning\nin Drosophila","volume":"27","author":"Kim","year":"2007","journal-title":"J. Neurosci."},{"issue":"2","key":"2026100208422086100_cit3","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s12264-014-1507-3","article-title":"Dopaminergic\nModulation of Synaptic Plasticity in Rat\nPrefrontal Neurons","volume":"31","author":"Otani","year":"2015","journal-title":"Neurosci. Bull."},{"key":"2026100208422086100_cit4","doi-asserted-by":"publisher","first-page":"105674","DOI":"10.1016\/j.nbd.2022.105674","article-title":"Dopaminergic\nModulation of Primary Motor Cortex: From Cellular and Synaptic Mechanisms\nUnderlying Motor Learning to Cognitive Symptoms in Parkinson\u2019s\nDisease","volume":"167","author":"Cousineau","year":"2022","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"2026100208422086100_cit5","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1124\/pr.110.002642","article-title":"The Physiology, Signaling, and Pharmacology\nof Dopamine\nReceptors","volume":"63","author":"Beaulieu","year":"2011","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"2026100208422086100_cit6","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3390\/cells10040735","article-title":"Dopamine:\nThe Neuromodulator of Long-Term Synaptic\nPlasticity, Reward and Movement Control","volume":"10","author":"Speranza","year":"2021","journal-title":"Cells"},{"issue":"8","key":"2026100208422086100_cit7","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1016\/j.celrep.2017.10.108","article-title":"Dopamine Receptor\nDAMB Signals via Gq to Mediate Forgetting in Drosophila","volume":"21","author":"Himmelreich","year":"2017","journal-title":"Cell Rep."},{"issue":"1","key":"2026100208422086100_cit8","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.cell.2019.05.040","article-title":"Distinct Dopamine Receptor\nPathways Underlie the Temporal Sensitivity of Associative Learning","volume":"178","author":"Handler","year":"2019","journal-title":"Cell"},{"key":"2026100208422086100_cit9","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/bcpt.13277","article-title":"Come Fly with Me: An Overview of\nDopamine Receptors in Drosophila Melanogaster","volume":"126","author":"Karam","year":"2020","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"2","key":"2026100208422086100_cit10","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0014-5793(95)00224-W","article-title":"A Primordial\nDopamine D1-like Adenylyl Cyclase-Linked Receptor from Drosophila\nMelanogaster Displaying Poor Affinity for Benzazepines","volume":"362","author":"Sugamori","year":"1995","journal-title":"FEBS Lett."},{"issue":"6","key":"2026100208422086100_cit11","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/S0896-6273(00)80139-7","article-title":"DAMB, a Novel Dopamine\nReceptor Expressed Specifically in Drosophila Mushroom Bodies","volume":"16","author":"Han","year":"1996","journal-title":"Neuron"},{"key":"2026100208422086100_cit12","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3389\/fphar.2018.00332","article-title":"Compartmentalized\ncAMP Signaling Associated With Lipid\nRaft and Non-Raft Membrane Domains in Adult Ventricular Myocytes","volume":"9","author":"Agarwal","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"6","key":"2026100208422086100_cit13","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1016\/j.cell.2020.07.035","article-title":"Optical Mapping of cAMP Signaling\nat the Nanometer Scale","volume":"182","author":"Bock","year":"2020","journal-title":"Cell"},{"issue":"7","key":"2026100208422086100_cit14","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1016\/j.cell.2022.02.011","article-title":"Receptor-Associated Independent cAMP Nanodomains\nMediate Spatiotemporal Specificity of GPCR Signaling","volume":"185","author":"Anton","year":"2022","journal-title":"Cell"},{"issue":"24","key":"2026100208422086100_cit15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1406459111","article-title":"Probing\nNuclear Pore Complex Architecture\nwith Proximity-Dependent Biotinylation","volume":"111","author":"Kim","year":"2014","journal-title":"Proc.\nNatl. Acad. Sci. U. S. A."},{"issue":"9","key":"2026100208422086100_cit16","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/nbt.4201","article-title":"Efficient\nProximity Labeling in Living Cells and Organisms with TurboID","volume":"36","author":"Branon","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"2026100208422086100_cit17","doi-asserted-by":"publisher","first-page":"RP99650","DOI":"10.7554\/eLife.99650","article-title":"Executioner Caspase\nIs Proximal to Fasciclin 3 Which\nFacilitates Non-Lethal Activation in Drosophila Olfactory Receptor\nNeurons","volume":"13","author":"Muramoto","year":"2025","journal-title":"Elife"},{"issue":"11","key":"2026100208422086100_cit18","doi-asserted-by":"publisher","first-page":"7515","DOI":"10.1021\/jacs.3c13183","article-title":"Tyrosinase-Based\nProximity Labeling in Living Cells and In Vivo","volume":"146","author":"Zhu","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"2026100208422086100_cit19","doi-asserted-by":"publisher","first-page":"4855","DOI":"10.1038\/s41467-021-25144-y","article-title":"Cell-Type and Subcellular Compartment-Specific APEX2\nProximity Labeling Reveals Activity-Dependent Nuclear Proteome Dynamics\nin the Striatum","volume":"12","author":"Dumrongprechachan","year":"2021","journal-title":"Nat. Commun."},{"key":"2026100208422086100_cit20","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70921","article-title":"Subcellular Proteomics\nof Dopamine Neurons in the Mouse\nBrain","volume":"11","author":"Hobson","year":"2022","journal-title":"Elife"},{"issue":"2","key":"2026100208422086100_cit21","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.cell.2017.03.028","article-title":"Multidimensional\nTracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling","volume":"169","author":"Paek","year":"2017","journal-title":"Cell"},{"issue":"5147","key":"2026100208422086100_cit22","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1126\/science.8303280","article-title":"Associative Odor Learning in Drosophila\nAbolished by Chemical Ablation of Mushroom Bodies","volume":"263","author":"de Belle","year":"1994","journal-title":"Science"},{"issue":"7","key":"2026100208422086100_cit23","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1002\/bies.1083","article-title":"Molecular Biology\nand Anatomy of Drosophila Olfactory\nAssociative Learning","volume":"23","author":"Roman","year":"2001","journal-title":"Bioessays"},{"issue":"3","key":"2026100208422086100_cit24","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.conb.2013.01.005","article-title":"Reinforcement\nSignalling in Drosophila; Dopamine Does It All after All","volume":"23","author":"Waddell","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"issue":"6","key":"2026100208422086100_cit25","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1007\/s12264-021-00665-0","article-title":"The Role of Dopamine\nin Associative Learning in Drosophila:\nAn Updated Unified Model","volume":"37","author":"Adel","year":"2021","journal-title":"Neurosci. Bull."},{"issue":"9","key":"2026100208422086100_cit26","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.1038\/s41380-024-02521-9","article-title":"Active Forgetting and Neuropsychiatric\nDiseases","volume":"29","author":"Berry","year":"2024","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"2026100208422086100_cit27","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S1567-133X(02)00098-4","article-title":"Expression of a\nD1 Dopamine Receptor dDA1\/DmDOP1 in the Central Nervous System of\nDrosophila Melanogaster","volume":"3","author":"Kim","year":"2003","journal-title":"Gene Expression Patterns"},{"issue":"7","key":"2026100208422086100_cit28","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.cub.2012.02.014","article-title":"Gamma Neurons Mediate\nDopaminergic Input during Aversive\nOlfactory Memory Formation in Drosophila","volume":"22","author":"Qin","year":"2012","journal-title":"Curr.\nBiol."},{"issue":"3","key":"2026100208422086100_cit29","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.neuron.2012.04.007","article-title":"Dopamine\nIs Required\nfor Learning and Forgetting in Drosophila","volume":"74","author":"Berry","year":"2012","journal-title":"Neuron"},{"issue":"6","key":"2026100208422086100_cit30","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/j.neuron.2016.05.010","article-title":"Scribble Scaffolds\na Signalosome for Active Forgetting","volume":"90","author":"Cervantes-Sandoval","year":"2016","journal-title":"Neuron"},{"issue":"4","key":"2026100208422086100_cit31","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nn.3055","article-title":"Slow Oscillations in Two Pairs of\nDopaminergic Neurons Gate Long-Term Memory Formation in Drosophila","volume":"15","author":"Plac\u0327ais","year":"2012","journal-title":"Nat. Neurosci."},{"issue":"11","key":"2026100208422086100_cit32","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1016\/j.cub.2018.04.040","article-title":"A GABAergic Feedback\nShapes Dopaminergic Input on the Drosophila Mushroom Body to Promote\nAppetitive Long-Term Memory","volume":"28","author":"Pavlowsky","year":"2018","journal-title":"Curr. Biol."},{"issue":"2","key":"2026100208422086100_cit33","doi-asserted-by":"publisher","first-page":"112026","DOI":"10.1016\/j.celrep.2023.112026","article-title":"Innate and Learned\nOdor-Guided Behaviors Utilize Distinct\nMolecular Signaling Pathways in a Shared Dopaminergic Circuit","volume":"42","author":"Noyes","year":"2023","journal-title":"Cell Rep."},{"issue":"5","key":"2026100208422086100_cit34","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.neuron.2019.01.045","article-title":"Chemoconnectomics:\nMapping Chemical Transmission in Drosophila","volume":"101","author":"Deng","year":"2019","journal-title":"Neuron"},{"issue":"2","key":"2026100208422086100_cit35","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.3","article-title":"Novel, Primate-Specific PDE10A Isoform Highlights Gene\nExpression Complexity in Human Striatum with Implications on the Molecular\nPathology of Bipolar Disorder","volume":"6","author":"MacMullen","year":"2016","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"2026100208422086100_cit36","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nmeth763","article-title":"An Inducible\nTranslocation Strategy to Rapidly Activate and Inhibit Small GTPase\nSignaling Pathways","volume":"2","author":"Inoue","year":"2005","journal-title":"Nat. Methods"},{"issue":"18","key":"2026100208422086100_cit37","doi-asserted-by":"publisher","first-page":"8392","DOI":"10.1073\/pnas.90.18.8392","article-title":"Production\nof High-Titer Helper-Free Retroviruses by Transient Transfection","volume":"90","author":"Pear","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"2026100208422086100_cit38","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1021\/cb200248h","article-title":"A Luminescent Biosensor with Increased Dynamic Range\nfor Intracellular cAMP","volume":"6","author":"Binkowski","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"2026100208422086100_cit39","doi-asserted-by":"publisher","first-page":"13268","DOI":"10.1038\/ncomms13268","article-title":"Coupling Optogenetic Stimulation\nwith NanoLuc-Based Luminescence (BRET) Ca++ Sensing","volume":"7","author":"Yang","year":"2016","journal-title":"Nat. Commun."},{"key":"2026100208422086100_cit40","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/978-1-4939-2914-6_8","article-title":"Monitoring G Protein Activation in\nCells with BRET","volume":"1335","author":"Masuho","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"2026100208422086100_cit41","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING\ndatabase in 2021: customizable protein\u2013protein\nnetworks, and functional characterization of user-uploaded gene\/measurement\nsets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"2026100208422086100_cit42","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/s12859-017-1866-7","article-title":"A Strategy for Evaluating Pathway Analysis Methods","volume":"18","author":"Yu","year":"2017","journal-title":"BMC Bioinf."},{"key":"2026100208422086100_cit43","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1186\/1471-2105-12-357","article-title":"An Integrative Approach to Ortholog\nPrediction for Disease-Focused and Other Functional Studies","volume":"12","author":"Hu","year":"2011","journal-title":"BMC Bioinf."},{"key":"2026100208422086100_cit44","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49257","article-title":"Nitric\noxide acts as a cotransmitter in\na subset of dopaminergic neurons to diversify memory dynamics","volume":"8","author":"Aso","year":"2019","journal-title":"Elife"},{"issue":"2","key":"2026100208422086100_cit45","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/BF01350033","article-title":"Classical Conditioning\nand Retention in Normal and\nMutant Drosophila Melanogaster","volume":"157","author":"Tully","year":"1985","journal-title":"J. Comp. Physiol.\nA"},{"issue":"4","key":"2026100208422086100_cit46","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.neuron.2009.09.029","article-title":"Dynamics of Learning-Related cAMP Signaling and Stimulus\nIntegration in the Drosophila Olfactory Pathway","volume":"64","author":"Tomchik","year":"2009","journal-title":"Neuron"},{"issue":"36","key":"2026100208422086100_cit47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411087111","article-title":"Ultrafast\nTissue Staining with Chemical Tags","volume":"111","author":"Kohl","year":"2014","journal-title":"Proc. Natl.\nAcad. Sci. U. S. A."},{"issue":"8","key":"2026100208422086100_cit48","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/nrm3151","article-title":"Molecular Mechanism\nand Physiological Functions of\nClathrin-Mediated Endocytosis","volume":"12","author":"McMahon","year":"2011","journal-title":"Nat. Rev. Mol.\nCell Biol."},{"issue":"13","key":"2026100208422086100_cit49","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.1523\/JNEUROSCI.4338-05.2006","article-title":"B-Ephrin Reverse Signaling Is Required\nfor NMDA-Independent Long-Term Potentiation of Mossy Fibers in the\nHippocampus","volume":"26","author":"Armstrong","year":"2006","journal-title":"J. Neurosci."},{"issue":"1","key":"2026100208422086100_cit50","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.mcn.2012.03.004","article-title":"Ephrin Regulation\nof Synapse Formation, Function and\nPlasticity","volume":"50","author":"Hruska","year":"2012","journal-title":"Mol. Cell. Neurosci."},{"issue":"3","key":"2026100208422086100_cit51","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/jnc.12816","article-title":"The Neuroplastin\nAdhesion Molecules: Key Regulators of Neuronal Plasticity and Synaptic\nFunction","volume":"131","author":"Beesley","year":"2014","journal-title":"J. Neurochem."},{"issue":"13","key":"2026100208422086100_cit52","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1016\/j.cub.2025.05.047","article-title":"Rapid Memory Shift between Different\nSynaptic Ensembles Promotes Forgetting in Drosophila","volume":"35","author":"Huang","year":"2025","journal-title":"Curr. Biol."},{"issue":"1","key":"2026100208422086100_cit53","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41594-017-0011-7","article-title":"Structure and Dynamics\nof GPCR Signaling\nComplexes","volume":"25","author":"Hilger","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2026100208422086100_cit54","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/bs.pmbts.2022.09.005","article-title":"Endocytosis of Dopamine\nReceptor: Signaling in Brain","volume":"196","author":"Kawahata","year":"2023","journal-title":"Prog. Mol. Biol.\nTransl. Sci."},{"issue":"2","key":"2026100208422086100_cit55","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0301-0082(01)00023-5","article-title":"Endocytosis\nof G Protein-Coupled Receptors: Roles of G Protein-Coupled Receptor\nKinases and \u00df-Arrestin Proteins","volume":"66","author":"Claing","year":"2002","journal-title":"Prog.\nNeurobiol."},{"issue":"9","key":"2026100208422086100_cit56","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.tips.2011.05.002","article-title":"\u03b2-Arrestin-Mediated Receptor\nTrafficking and\nSignal Transduction","volume":"32","author":"Shenoy","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"issue":"4","key":"2026100208422086100_cit57","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1080\/21541248.2017.1282402","article-title":"New Insights into Mechanisms of Nuclear\nTranslocation of G-Protein Coupled Receptors","volume":"10","author":"Bhosle","year":"2019","journal-title":"Small GTPases"},{"issue":"10","key":"2026100208422086100_cit58","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.3390\/biom12101343","article-title":"GPCRs in Intracellular Compartments: New Targets for Drug Discovery","volume":"12","author":"Fasciani","year":"2022","journal-title":"Biomolecules"},{"issue":"4","key":"2026100208422086100_cit59","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.celrep.2012.09.011","article-title":"A GAL4-Driver\nLine Resource for Drosophila Neurobiology","volume":"2","author":"Jenett","year":"2012","journal-title":"Cell\nRep."},{"issue":"11","key":"2026100208422086100_cit60","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.ibmb.2008.09.003","article-title":"Functional\nCharacterization of Kurtz, a Drosophila Non-Visual Arrestin, Reveals\nConservation of GPCR Desensitization Mechanisms","volume":"38","author":"Johnson","year":"2008","journal-title":"Insect Biochem. Mol. Biol."},{"issue":"20","key":"2026100208422086100_cit61","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1016\/j.neuron.2021.08.001","article-title":"Memory\nSuppressor Genes: Modulating\nAcquisition, Consolidation, and Forgetting","volume":"109","author":"Noyes","year":"2021","journal-title":"Neuron"},{"issue":"12","key":"2026100208422086100_cit62","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/tra.12817","article-title":"A Systematic Review\nof Sec24 Cargo\nInteractome","volume":"22","author":"Chatterjee","year":"2021","journal-title":"Traffic"},{"issue":"1","key":"2026100208422086100_cit63","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.celrep.2019.12.018","article-title":"Neurochemical Organization of the Drosophila Brain\nVisualized by Endogenously Tagged Neurotransmitter Receptors","volume":"30","author":"Kondo","year":"2020","journal-title":"Cell Rep."},{"issue":"4","key":"2026100208422086100_cit64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019170","article-title":"A mTurquoise-Based\ncAMP Sensor for Both FLIM and Ratiometric Read-Out Has Improved Dynamic\nRange","volume":"6","author":"Klarenbeek","year":"2011","journal-title":"PLoS One"},{"issue":"7","key":"2026100208422086100_cit65","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1016\/j.cell.2015.05.027","article-title":"Sleep Facilitates\nMemory by Blocking Dopamine Neuron-Mediated Forgetting","volume":"161","author":"Berry","year":"2015","journal-title":"Cell"},{"issue":"3","key":"2026100208422086100_cit66","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.celrep.2018.09.051","article-title":"Dopamine Neurons\nMediate Learning\nand Forgetting through Bidirectional Modulation of a Memory Trace","volume":"25","author":"Berry","year":"2018","journal-title":"Cell Rep."},{"key":"2026100208422086100_cit67","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76712","article-title":"Associative Learning Drives Longitudinally\nGraded Presynaptic Plasticity of Neurotransmitter Release along Axonal\nCompartments","volume":"11","author":"Stahl","year":"2022","journal-title":"Elife"},{"issue":"8036","key":"2026100208422086100_cit68","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1038\/s41586-024-07819-w","article-title":"Dopamine-Mediated\nInteractions between Short- and Long-Term Memory Dynamics","volume":"634","author":"Huang","year":"2024","journal-title":"Nature"},{"issue":"5","key":"2026100208422086100_cit69","doi-asserted-by":"publisher","first-page":"115593","DOI":"10.1016\/j.celrep.2025.115593","article-title":"Functional Dissection\nof a Neuronal Brain Circuit Mediating Higher-Order\nAssociative Learning","volume":"44","author":"Rachad","year":"2025","journal-title":"Cell Rep."},{"issue":"19","key":"2026100208422086100_cit70","doi-asserted-by":"publisher","first-page":"3850","DOI":"10.1016\/j.jmb.2016.08.002","article-title":"Regulation, Signaling\nand Physiological Functions of G-Proteins","volume":"428","author":"Syrovatkina","year":"2016","journal-title":"J.\nMol. Biol."},{"issue":"1","key":"2026100208422086100_cit71","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1161\/CIRCRESAHA.124.323067","article-title":"G Protein-Coupled Receptors: A Century of Research\nand Discovery","volume":"135","author":"Liu","year":"2024","journal-title":"Circ. Res."},{"key":"2026100208422086100_cit72","doi-asserted-by":"publisher","first-page":"3445","DOI":"10.1016\/j.csbj.2024.09.014","article-title":"Uncovering Conserved\nNetworks and Global Conformational Changes in\nG Protein-Coupled Receptor Kinases","volume":"23","author":"Seo","year":"2024","journal-title":"Comput.\nStruct. Biotechnol. J."},{"issue":"1","key":"2026100208422086100_cit73","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1113\/jphysiol.2012.242909","article-title":"Long-Term\nEnhancement of Synaptic Transmission between Antennal Lobe and Mushroom\nBody in Cultured Drosophila Brain","volume":"591","author":"Ueno","year":"2013","journal-title":"J. Physiol."},{"issue":"5","key":"2026100208422086100_cit74","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.neuron.2011.12.032","article-title":"Dopaminergic Modulation of Sucrose\nAcceptance Behavior in Drosophila","volume":"73","author":"Marella","year":"2012","journal-title":"Neuron"},{"key":"2026100208422086100_cit75","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35264","article-title":"Drosophila\nMushroom Bodies Integrate Hunger and Satiety Signals to Control Innate\nFood-Seeking Behavior","volume":"7","author":"Tsao","year":"2018","journal-title":"Elife"},{"issue":"17","key":"2026100208422086100_cit76","doi-asserted-by":"publisher","first-page":"3941","DOI":"10.1016\/j.cub.2024.07.056","article-title":"Light and Dopamine Impact Two Circadian\nNeurons to Promote Morning Wakefulness","volume":"34","author":"Le","year":"2024","journal-title":"Curr.\nBiol."},{"key":"2026100208422086100_cit77","doi-asserted-by":"publisher","first-page":"1581307","DOI":"10.3389\/finsc.2025.1581307","article-title":"The Role of Dopamine in Foraging\nDecisions in Social Insects","volume":"5","author":"Ye","year":"2025","journal-title":"Front. Insect Sci."},{"key":"2026100208422086100_cit78","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/bs.mcb.2015.11.008","article-title":"Localization and\nSignaling of GPCRs in Lipid Rafts","volume":"132","author":"Villar","year":"2016","journal-title":"Methods Cell\nBiol."},{"issue":"23","key":"2026100208422086100_cit79","doi-asserted-by":"publisher","first-page":"8909","DOI":"10.3390\/ijms21238909","article-title":"Lipid Rafts and\nDopamine Receptor Signaling","volume":"21","author":"Martinez","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"2026100208422086100_cit80","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.3390\/biom13101552","article-title":"G Protein-Coupled\nReceptor Kinase 2 Selectively Enhances \u03b2-Arrestin Recruitment\nto the D2 Dopamine Receptor through Mechanisms That Are Independent\nof Receptor Phosphorylation","volume":"13","author":"Sa\u0301nchez-Soto","year":"2023","journal-title":"Biomolecules"},{"key":"2026100208422086100_cit81","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1186\/1471-2105-9-529","article-title":"The APEX Quantitative\nProteomics Tool: Generating Protein Quantitation Estimates from LC-MS\/MS\nProteomics Results","volume":"9","author":"Braisted","year":"2008","journal-title":"BMC Bioinf."},{"issue":"6","key":"2026100208422086100_cit82","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s41592-023-01880-5","article-title":"Engineered Allostery in Light-Regulated\nLOV-Turbo Enables\nPrecise Spatiotemporal Control of Proximity Labeling in Living Cells","volume":"20","author":"Lee","year":"2023","journal-title":"Nat. Methods"},{"issue":"3","key":"2026100208422086100_cit83","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/cm.20437","article-title":"WASH and the Arp2\/3 Complex Regulate\nEndosome Shape\nand Trafficking","volume":"67","author":"Duleh","year":"2010","journal-title":"Cytoskeleton"},{"issue":"38","key":"2026100208422086100_cit84","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207011109","article-title":"Molecular Basis for\nCoupling the Plasma Membrane to\nthe Actin Cytoskeleton during Clathrin-Mediated Endocytosis","volume":"109","author":"Skruzny","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"2026100208422086100_cit85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019942","article-title":"Receptor Sorting within\nEndosomal Trafficking Pathway Is Facilitated\nby Dynamic Actin Filaments","volume":"6","author":"Ohashi","year":"2011","journal-title":"PLoS One"},{"key":"2026100208422086100_cit86","doi-asserted-by":"publisher","first-page":"618652","DOI":"10.3389\/fcell.2020.618652","article-title":"Export Control:\nPost-Transcriptional Regulation of the COPII Trafficking Pathway","volume":"8","author":"Bisnett","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"6663","key":"2026100208422086100_cit87","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/34438","article-title":"COPII-Cargo Interactions Direct Protein\nSorting into ER-Derived Transport Vesicles","volume":"391","author":"Kuehn","year":"1998","journal-title":"Nature"},{"issue":"11","key":"2026100208422086100_cit88","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.1016\/j.febslet.2007.01.091","article-title":"Mechanisms of COPII Vesicle Formation and Protein Sorting","volume":"581","author":"Sato","year":"2007","journal-title":"FEBS Lett."},{"issue":"10","key":"2026100208422086100_cit89","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1177\/002215540104901005","article-title":"Endoplasmic Reticulum\nMembrane-Sorting Protein of Lymphocytes\n(BAP31) Is Highly Expressed in Neurons and Discrete Endocrine Cells","volume":"49","author":"Manley","year":"2001","journal-title":"J. Histochem. Cytochem."},{"issue":"3","key":"2026100208422086100_cit90","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.ajhg.2013.07.023","article-title":"Mutations in BCAP31 Cause a Severe X-Linked Phenotype\nwith Deafness, Dystonia, and Central Hypomyelination and Disorganize\nthe Golgi Apparatus","volume":"93","author":"Cacciagli","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"2026100208422086100_cit91","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.biochi.2021.04.008","article-title":"BAP31:\nPhysiological Functions and Roles in Disease","volume":"186","author":"Quistgaard","year":"2021","journal-title":"Biochimie"},{"issue":"9","key":"2026100208422086100_cit92","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1038\/s41431-021-00821-0","article-title":"Further Delineation\nof BCAP31-Linked Intellectual Disability: Description of 17 New Families\nwith LoF and Missense Variants","volume":"29","author":"Whalen","year":"2021","journal-title":"Eur. J. Hum.\nGenet."}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.6c00259","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/10\/5339\/68506060\/acs.jproteome.6c00259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/10\/5339\/68506060\/acs.jproteome.6c00259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:10:38Z","timestamp":1790946638000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jprobs\/article\/25\/10\/5339\/5429687\/Proximity-Labeling-of-D1-Like-Dopamine-Receptors"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":92,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,14]]},"published-print":{"date-parts":[[2026,10,2]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.6c00259","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]}}}