{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:23:04Z","timestamp":1788535384428,"version":"build-2803163510"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002836","name":"Chang Gung University","doi-asserted-by":"publisher","award":["URRPD1R0011"],"award-info":[{"award-number":["URRPD1R0011"]}],"id":[{"id":"10.13039\/501100002836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["115-2314-B-182-036"],"award-info":[{"award-number":["115-2314-B-182-036"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alterations in circulating bile acids (BAs) have been reported in inflammatory bowel disease (IBD), but the consistency of these changes across clinically relevant comparisons remains unclear. Our goal was to investigate systemic BA alterations in IBD using a metabolomics meta-analysis with an exploratory analysis of BA-related gene expression as a supporting context. A systematic review and meta-analysis of 28 metabolomics studies examined blood BA profiles associated with IBD, IBD diagnosis, and disease activity assessment. Univariate analysis and logistic regression modeling of two independent IBD cohorts explored the blood BA-related genes and IBD. Across 28 studies that comprised 5056 IBD patients, 1721 healthy controls, and 314 non-IBD patients, 131 BAs were reported. Eight predefined clinical comparisons were eligible for the meta-analysis. Lower secondary BA levels were consistently observed in IBD patients compared with controls, between UC and CD, and in active versus remission patients. Deoxycholic acid, glycodeoxycholic acid, and taurodeoxycholic acid were frequently decreased, whereas glycocholic acid was increased in certain comparisons. Transcriptomics analyses revealed differential expression of several BA-related genes in blood, including SLC51A, ABCB4, and ACOT8, across the comparisons. Our findings identify consistent circulating BA alterations in IBD and highlight the relevance of blood BA for future biomarker research in the diagnosis and disease activity assessment.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00383","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:45:20Z","timestamp":1788212720000},"page":"4847-4858","source":"Crossref","is-referenced-by-count":0,"title":["Blood Bile\nAcids for Inflammatory Bowel Disease Diagnosis\nand Disease Activity Assessment: A Metabolomics Meta-Analysis"],"prefix":"10.1021","volume":"25","author":[{"given":"Nguyen Quang","family":"Thu","sequence":"first","affiliation":[{"name":"Chang Gung University , , ,","place":["Taoyuan, Taiwan, 333"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vo Thuy","family":"An","sequence":"additional","affiliation":[{"name":"Chang Gung University , , ,","place":["Taoyuan, Taiwan, 333"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Hoang Bach","family":"Dat","sequence":"additional","affiliation":[{"name":"University of Science , , ,","place":["Ho Chi Minh City, Vietnam, 700000"]},{"name":"Vietnam National University Ho Chi Minh City (VNU-HCM) , ,","place":["Ho Chi Minh City, Vietnam, 700000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Minh","family":"Hung","sequence":"additional","affiliation":[{"name":"Ton Duc Thang University , , ,","place":["Ho Chi Minh City, Vietnam, 700000"]},{"name":"Ton Duc Thang University , , ,","place":["Ho Chi Minh City, Vietnam, 700000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy Truong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Ton Duc Thang University , , ,","place":["Ho Chi Minh City, Vietnam, 700000"]},{"name":"Ton Duc Thang University , , ,","place":["Ho Chi Minh City, Vietnam, 700000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4678-0546","authenticated-orcid":true,"given":"Nguyen Phuoc","family":"Long","sequence":"additional","affiliation":[{"name":"Chang Gung University , , ,","place":["Taoyuan, Taiwan, 333"]},{"name":"Chang Gung University , , ,","place":["Taoyuan, Taiwan, 333"]},{"name":"Linkou Branch , , ,","place":["Taoyuan, Taiwan, 333"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"issue":"6","key":"2026090409125131400_cit1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41575-022-00593-y","article-title":"Multiomics\nto elucidate inflammatory bowel disease risk factors and pathways","volume":"19","author":"Agrawal","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"10","key":"2026090409125131400_cit2","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/s41575-025-01097-1","article-title":"The global\nburden of inflammatory bowel disease: from 2025 to 2045","volume":"22","author":"Kaplan","year":"2025","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"2026090409125131400_cit3","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"2026090409125131400_cit4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","article-title":"Crohn\u2019s disease","volume":"6","author":"Roda","year":"2020","journal-title":"Nat.\nRev. Dis. Primers"},{"issue":"27","key":"2026090409125131400_cit5","doi-asserted-by":"publisher","first-page":"2652","DOI":"10.1056\/NEJMra2002697","article-title":"Pathophysiology\nof Inflammatory Bowel Diseases","volume":"383","author":"Chang","year":"2020","journal-title":"N. Engl. J.\nMed."},{"issue":"10","key":"2026090409125131400_cit6","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nrgastro.2016.128","article-title":"Current\nbest practice for disease\nactivity assessment in IBD","volume":"13","author":"Walsh","year":"2016","journal-title":"Nat. Rev. Gastroenterol.\nHepatol."},{"issue":"10","key":"2026090409125131400_cit7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s44321-024-00129-8","article-title":"Multiomics\nreveals microbial metabolites as key actors in intestinal fibrosis\nin Crohn\u2019s disease","volume":"16","author":"Li","year":"2024","journal-title":"EMBO Mol. Med."},{"issue":"3","key":"2026090409125131400_cit8","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1093\/ibd\/izad185","article-title":"Microbial\nand Metabolite\nSignatures of Stress Reactivity in Ulcerative Colitis Patients in\nClinical Remission Predict Clinical Flare Risk","volume":"30","author":"Jacobs","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"issue":"4","key":"2026090409125131400_cit9","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1136\/gutjnl-2012-302578","article-title":"Connecting\ndysbiosis, bile-acid dysmetabolism and gut\ninflammation in inflammatory bowel diseases","volume":"62","author":"Duboc","year":"2013","journal-title":"Gut"},{"issue":"7758","key":"2026090409125131400_cit10","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/s41586-019-1237-9","article-title":"Multi-omics\nof the gut microbial ecosystem\nin inflammatory bowel diseases","volume":"569","author":"Lloyd-Price","year":"2019","journal-title":"Nature"},{"issue":"11","key":"2026090409125131400_cit11","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1136\/gutjnl-2023-329969","article-title":"Untargeted\nfaecal metabolomics for the discovery of biomarkers and treatment\ntargets for inflammatory bowel diseases","volume":"73","author":"Vich Vila","year":"2024","journal-title":"Gut"},{"issue":"2","key":"2026090409125131400_cit12","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41564-018-0306-4","article-title":"Gut microbiome structure and metabolic activity\nin inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"11","key":"2026090409125131400_cit13","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.3390\/metabo13111112","article-title":"Molecular\nand Metabolic Phenotyping of Hepatocellular Carcinoma for Biomarker\nDiscovery: A Meta-Analysis","volume":"13","author":"Anh","year":"2023","journal-title":"Metabolites"},{"issue":"16","key":"2026090409125131400_cit14","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.clinbiochem.2008.06.018","article-title":"QUADOMICS:\nAn adaptation\nof the Quality Assessment of Diagnostic Accuracy Assessment (QUADAS)\nfor the evaluation of the methodological quality of studies on the\ndiagnostic accuracy of \u2018-omics\u2019-based technologies","volume":"41","author":"Lumbreras","year":"2008","journal-title":"Clin. Biochem."},{"issue":"5","key":"2026090409125131400_cit15","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1021\/acs.jproteome.4c01051","article-title":"metLinkR:\nFacilitating Metaanalysis of Human Metabolomics Data through Automated\nLinking of Metabolite Identifiers","volume":"24","author":"Patt","year":"2025","journal-title":"J. Proteome\nRes."},{"issue":"5","key":"2026090409125131400_cit16","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/s42255-023-00777-z","article-title":"Human metabolome\nvariation along the upper intestinal tract","volume":"5","author":"Folz","year":"2023","journal-title":"Nat. Metab."},{"issue":"1","key":"2026090409125131400_cit17","doi-asserted-by":"publisher","first-page":"6980","DOI":"10.1038\/s41598-021-86465-y","article-title":"Powerful p-value combination\nmethods to detect incomplete association","volume":"11","author":"Yoon","year":"2021","journal-title":"Sci.\nRep."},{"issue":"2","key":"2026090409125131400_cit18","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1093\/bioinformatics\/btab591","article-title":"Amanida: an\nR package for meta-analysis of metabolomics non-integral data","volume":"38","author":"Llambrich","year":"2022","journal-title":"Bioinformatics"},{"issue":"1","key":"2026090409125131400_cit19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto Encyclopedia\nof Genes and Genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"2026090409125131400_cit20","doi-asserted-by":"publisher","first-page":"btac726","DOI":"10.1093\/bioinformatics\/btac726","article-title":"RaMP-DB\n2.0: a renovated knowledgebase for deriving biological and chemical\ninsight from metabolites, proteins, and genes","volume":"39","author":"Braisted","year":"2022","journal-title":"Bioinformatics"},{"issue":"12","key":"2026090409125131400_cit21","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB)\n3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"issue":"1","key":"2026090409125131400_cit22","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s12944-020-01390-9","article-title":"Lipid metabolism gene-wide\nprofile and survival signature of lung adenocarcinoma","volume":"19","author":"Li","year":"2020","journal-title":"Lipids Health Dis."},{"key":"2026090409125131400_cit23","doi-asserted-by":"publisher","first-page":"853468","DOI":"10.3389\/fcvm.2022.853468","article-title":"Screening of Lipid\nMetabolism-Related Gene Diagnostic Signature for Patients With Dilated\nCardiomyopathy","volume":"9","author":"Xu","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"2026090409125131400_cit24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41392-024-01811-6","article-title":"Bile acid metabolism and signaling\nin health and disease: molecular\nmechanisms and therapeutic targets","volume":"9","author":"Fleishman","year":"2024","journal-title":"Signal.\nTransduct. Target Ther"},{"key":"2026090409125131400_cit25","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/B978-0-12-824048-9.00016-X","article-title":"Chapter 12\n- Bile acid metabolism","volume-title":"Biochemistry of\nLipids, Lipoproteins and Membranes","author":"Truong","year":"2021","edition":"7"},{"issue":"7","key":"2026090409125131400_cit26","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1136\/gutjnl-2021-326451","article-title":"Biopsy and blood-based molecular biomarker of inflammation in IBD","volume":"72","author":"Argmann","year":"2023","journal-title":"Gut"},{"issue":"2","key":"2026090409125131400_cit27","doi-asserted-by":"publisher","first-page":"100988","DOI":"10.1016\/j.jhepr.2023.100988","article-title":"Whole blood RNA sequencing identifies\ntranscriptional differences between primary sclerosing cholangitis\nand ulcerative colitis","volume":"6","author":"Wacker","year":"2024","journal-title":"JHEP Reports"},{"issue":"12","key":"2026090409125131400_cit28","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated\nestimation of fold change\nand dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"5","key":"2026090409125131400_cit29","doi-asserted-by":"publisher","first-page":"1-26","DOI":"10.18637\/jss.v028.i05","article-title":"Building Predictive\nModels in R Using the caret Package","volume":"28","author":"Kuhn","year":"2008","journal-title":"J. Stat.\nSoftw."},{"key":"2026090409125131400_cit30","volume-title":"A Language\nand Environment for Statistical Computing","author":"R Core Team","year":"2023"},{"issue":"W1","key":"2026090409125131400_cit31","doi-asserted-by":"publisher","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data\nprocessing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic\nAcids Res."},{"issue":"4","key":"2026090409125131400_cit32","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.1021\/acs.jproteome.5c01022","article-title":"EasyFigAssembler: Enhance Omics Data Storytelling through\nEffective Figure Assembly","volume":"25","author":"Long","year":"2026","journal-title":"J. Proteome Res."},{"issue":"4","key":"2026090409125131400_cit33","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1021\/acs.jproteome.2c00820","article-title":"Serum Bile\nAcid Metabolites Predict the Therapeutic\nEffect of Mesalazine in Patients with Ulcerative Colitis","volume":"22","author":"Sun","year":"2023","journal-title":"J. Proteome Res."},{"issue":"5","key":"2026090409125131400_cit34","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1007\/s10238-022-00931-z","article-title":"Untargeted\nmetabolomics\nidentifies potential serum biomarkers associated with Crohn\u2019s\ndisease","volume":"23","author":"Chen","year":"2023","journal-title":"Clin. Exp. Med."},{"issue":"3","key":"2026090409125131400_cit35","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3390\/molecules24030449","article-title":"Serum Metabolomics Identifies Altered\nBioenergetics,\nSignaling Cascades in Parallel with Exposome Markers in Crohn\u2019s\nDisease","volume":"24","author":"Lai","year":"2019","journal-title":"Molecules"},{"issue":"6","key":"2026090409125131400_cit36","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1080\/00365521.2024.2328592","article-title":"Plasma\nbile acids in association with Crohn\u2019s disease","volume":"59","author":"Kiasat","year":"2024","journal-title":"Scand. J. Gastroenterol."},{"issue":"1","key":"2026090409125131400_cit37","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101088rrr","article-title":"Co-occurrence of gut microbiota dysbiosis\nand bile\nacid metabolism alteration is associated with psychological disorders\nin Crohn\u2019s disease","volume":"36","author":"Feng","year":"2022","journal-title":"FASEB J."},{"issue":"2","key":"2026090409125131400_cit38","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1021\/acs.jproteome.9b00440","article-title":"UPLC\u2013QTOF-MS-Based\nPlasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel\nDisease Diagnosis","volume":"19","author":"Guan","year":"2020","journal-title":"J. Proteome Res."},{"key":"2026090409125131400_cit39","doi-asserted-by":"publisher","first-page":"814839","DOI":"10.3389\/fmed.2022.814839","article-title":"Untargeted\nserum metabolomics reveals specific metabolite abnormalities in patients\nwith Crohn\u2019s disease","volume":"9","author":"Liu","year":"2022","journal-title":"Front. Med."},{"issue":"1","key":"2026090409125131400_cit40","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1038\/s41598-020-58644-w","article-title":"Attenuation\nof bile\nacid-mediated FXR and PXR activation in patients with Crohn\u2019s\ndisease","volume":"10","author":"Wilson","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"2026090409125131400_cit41","doi-asserted-by":"publisher","first-page":"1680008","DOI":"10.1155\/2022\/1680008","article-title":"Alterations\nof Serum Bile Acid Profile in Patients with Crohn\u2019s Disease","volume":"2022","author":"Sun","year":"2022","journal-title":"Gastroenterol. res. pract."},{"issue":"1","key":"2026090409125131400_cit42","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s11306-017-1311-y","article-title":"Alterations in Lipid, Amino Acid, and Energy\nMetabolism Distinguish Crohn\u2019s Disease from Ulcerative Colitis\nand Control Subjects by Serum Metabolomic Profiling","volume":"14","author":"Scoville","year":"2018","journal-title":"Metabolomics"},{"issue":"1","key":"2026090409125131400_cit43","doi-asserted-by":"publisher","first-page":"2323231","DOI":"10.1080\/19490976.2024.2323231","article-title":"Bile acid\nprofiling as an effective biomarker for staging in pediatric\ninflammatory bowel disease","volume":"16","author":"Chen","year":"2024","journal-title":"Gut Microbes"},{"issue":"4","key":"2026090409125131400_cit44","doi-asserted-by":"crossref","first-page":"44","DOI":"10.12998\/wjcc.v6.i4.44","article-title":"High prevalence\nof cholestasis, with\nincreased conjugated bile acids in inflammatory bowel diseases patients","volume":"6","author":"Girardin","year":"2018","journal-title":"World J. Clin. Cases"},{"issue":"23","key":"2026090409125131400_cit45","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000038457","article-title":"Bile acid profiles and classification\nmodel accuracy for inflammatory bowel disease diagnosis","volume":"103","author":"Xu","year":"2024","journal-title":"Medicine"},{"issue":"10","key":"2026090409125131400_cit46","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1093\/ibd\/izad080","article-title":"A Novel\nSerum Metabolomic Panel for the Diagnosis of Crohn\u2019s Disease","volume":"29","author":"Ma","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"2026090409125131400_cit47","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14842","article-title":"Deoxycholic acid exacerbates\nintestinal inflammation by modulating\ninterleukin-1\u03b2 expression and tuft cell proportion in dextran\nsulfate sodium-induced murine colitis","volume":"11","author":"Ju","year":"2023","journal-title":"PeerJ"},{"issue":"25","key":"2026090409125131400_cit48","doi-asserted-by":"publisher","first-page":"3134","DOI":"10.3748\/wjg.15.3134","article-title":"Serum\nbile acid profiling reflects enterohepatic detoxification state and\nintestinal barrier function in inflammatory bowel disease","volume":"15","author":"Gnewuch","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"2026090409125131400_cit49","doi-asserted-by":"publisher","first-page":"116639","DOI":"10.1016\/j.jpba.2024.116639","article-title":"Plasma bile\nacid profile analysis by liquid chromatography-tandem mass spectrometry\nand its application in healthy subjects and IBD patients","volume":"255","author":"Gong","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"3","key":"2026090409125131400_cit50","first-page":"321","article-title":"Faecal and\nSerum Metabolomics in Paediatric Inflammatory Bowel Disease","volume":"11","author":"Kolho","year":"2016","journal-title":"J. Crohns Colitis"},{"issue":"3","key":"2026090409125131400_cit51","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1093\/ecco-jcc\/jjac149","article-title":"Mucosal and Plasma Metabolomes in\nNew-onset Paediatric Inflammatory Bowel Disease: Correlations with\nDisease Characteristics and Plasma Inflammation Protein Markers","volume":"17","author":"Nystro\u0308m","year":"2023","journal-title":"J. Crohns Colitis"},{"issue":"2","key":"2026090409125131400_cit52","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.chom.2023.12.013","article-title":"Linking microbial genes\nto plasma and stool metabolites uncovers host-microbial interactions\nunderlying ulcerative colitis disease course","volume":"32","author":"Schirmer","year":"2024","journal-title":"Cell Host Microbe"},{"key":"2026090409125131400_cit53","doi-asserted-by":"publisher","first-page":"116652","DOI":"10.1016\/j.jpba.2024.116652","article-title":"An exploratory\nmulti-omics\nstudy reveals distinct molecular signatures of ulcerative colitis\nand Crohn\u2019s disease and their correlation with disease activity","volume":"255","author":"Tien","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"12","key":"2026090409125131400_cit54","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1093\/ecco-jcc\/jjae096","article-title":"Inflammatory\nBowel Disease\nAssociated with Primary Sclerosing Cholangitis is Associated with\nan Altered Gut Microbiome and Bile Acid Profile","volume":"18","author":"Leibovitzh","year":"2024","journal-title":"J. Crohns Colitis"},{"issue":"3","key":"2026090409125131400_cit55","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1053\/j.gastro.2021.11.015","article-title":"Integrative\nAnalysis of the Inflammatory Bowel Disease Serum Metabolome\nImproves Our Understanding of Genetic Etiology and Points to Novel\nPutative Therapeutic Targets","volume":"162","author":"Di\u2019Narzo","year":"2022","journal-title":"Gastroenterology"},{"issue":"15","key":"2026090409125131400_cit56","doi-asserted-by":"publisher","first-page":"3340","DOI":"10.3390\/nu15153340","article-title":"The Underlying\nChanges in Serum Metabolic Profiles\nand Efficacy Prediction in Patients with Extensive Ulcerative Colitis\nUndergoing Fecal Microbiota Transplantation","volume":"15","author":"Wu","year":"2023","journal-title":"Nutrients"},{"issue":"8","key":"2026090409125131400_cit57","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1093\/ecco-jcc\/jjaa039","article-title":"Metabonomics\nand the Gut Microbiome Associated With\nPrimary Response to Anti-TNF Therapy in Crohn\u2019s Disease","volume":"14","author":"Ding","year":"2020","journal-title":"J. Crohns Colitis"},{"issue":"8","key":"2026090409125131400_cit58","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.chom.2021.06.019","article-title":"Multi-omics\nreveal microbial determinants impacting\nresponses to biologic therapies in inflammatory bowel disease","volume":"29","author":"Lee","year":"2021","journal-title":"Cell Host Microbe"},{"issue":"8","key":"2026090409125131400_cit59","doi-asserted-by":"publisher","first-page":"817","DOI":"10.3390\/cells8080817","article-title":"Serum Bile Acids Profiling in Inflammatory\nBowel Disease Patients Treated with Anti-TNFs","volume":"8","author":"Roda","year":"2019","journal-title":"Cells"},{"issue":"9","key":"2026090409125131400_cit60","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1080\/00365521.2023.2200518","article-title":"Bile acid alterations\nassociated with indolent course of inflammatory bowel disease","volume":"58","author":"Liu","year":"2023","journal-title":"Scand. J. Gastroenterol."},{"issue":"1","key":"2026090409125131400_cit61","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/metabo10010008","article-title":"A Perspective\nand Framework for Developing\nSample Type Specific Databases for LC\/MS-Based Clinical Metabolomics","volume":"10","author":"Reisdorph","year":"2019","journal-title":"Metabolites"},{"issue":"e1","key":"2026090409125131400_cit62","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2022-102117","article-title":"Imaging in\ninflammatory bowel disease: current and future perspectives","volume":"13","author":"Shaban","year":"2022","journal-title":"Frontline Gastroenterol."},{"issue":"4","key":"2026090409125131400_cit63","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41575-019-0258-z","article-title":"Gut microbiota-derived metabolites\nas key actors in inflammatory\nbowel disease","volume":"17","author":"Lavelle","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"8","key":"2026090409125131400_cit64","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1007\/s11739-023-03343-3","article-title":"The interaction\nof bile acids and gut inflammation influences the pathogenesis of\ninflammatory bowel disease","volume":"18","author":"Di Ciaula","year":"2023","journal-title":"Int. Emerg. Med."},{"issue":"8","key":"2026090409125131400_cit65","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41579-019-0213-6","article-title":"Microbial genes\nand pathways in inflammatory bowel disease","volume":"17","author":"Schirmer","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"issue":"6","key":"2026090409125131400_cit66","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.1021\/acs.analchem.5c05677","article-title":"MS\/MS Mass Spectrometry\nFiltering Tree for Bile Acid Regio- and Stereoisomer Annotation","volume":"98","author":"Mohanty","year":"2026","journal-title":"Anal. Chem."},{"issue":"4","key":"2026090409125131400_cit67","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41579-022-00805-x","article-title":"Bile acids\nand the gut microbiota: metabolic interactions and impacts on disease","volume":"21","author":"Collins","year":"2023","journal-title":"Nat. Rev. Microbiol."},{"key":"2026090409125131400_cit68","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jare.2025.05.015","article-title":"The\nfunctions\nof gut microbiota-mediated bile acid metabolism in intestinal immunity","volume":"80","author":"He","year":"2026","journal-title":"J. Adv. Res."},{"issue":"3","key":"2026090409125131400_cit69","doi-asserted-by":"publisher","first-page":"167037","DOI":"10.1016\/j.bbadis.2024.167037","article-title":"Impact\nof non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis\n(NASH) on the expression and function of hepatobiliary transporters:\nA comprehensive mechanistic review","volume":"1870","author":"Laddha","year":"2024","journal-title":"BBA Mol.\nBasis. Dis."},{"issue":"7","key":"2026090409125131400_cit70","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.tem.2017.03.001","article-title":"Deactivating\nFatty Acids: Acyl-CoA\nThioesterase-Mediated Control of Lipid Metabolism","volume":"28","author":"Tillander","year":"2017","journal-title":"Trends Endocrinol. Metab."}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.6c00383","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/9\/4847\/67393616\/acs.jproteome.6c00383.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/9\/4847\/67393616\/acs.jproteome.6c00383.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:54:00Z","timestamp":1788533640000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jprobs\/article\/25\/9\/4847\/5328278\/Blood-Bile-Acids-for-Inflammatory-Bowel-Disease"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":70,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,8,25]]},"published-print":{"date-parts":[[2026,9,4]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.6c00383","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]}}}