{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:28:40Z","timestamp":1788532120262,"version":"build-2803163510"},"reference-count":99,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000879","name":"Alfred P. Sloan Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001082","name":"Camille and Henry Dreyfus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["DP2-GM140926"],"award-info":[{"award-number":["DP2-GM140926"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Albstein Foundation for Brain Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cross-linking mass spectrometry (XL-MS) has advanced as a powerful approach to map protein\u2013protein interactions in cells. With recent advances in cross-linkers, instrumentation, and software, interactions can be observed in a proteome-wide fashion at residue-level resolution. In most XL-MS experiments, a chemical cross-linker possessing two electrophiles is added to a biological sample and records spatial information by forming covalent bonds between two proximal nucleophilic residues. On the other hand, photo-cross-linking amino acids that can be incorporated into proteins via ribosomal synthesis possess the capacity to rapidly capture transient protein\u2013protein interactions under physiological conditions without introducing exogenous reactive species. Diazirine-based photoamino acids have been widely used for this purpose due to their small size and broad reactivity. Recent studies have shown that diazirines can form MS-cleavable linkages when they react with acidic residues. However, confident interpretation of the resulting spectra and localization of cross-linking sites remain challenging, limiting broader application of diazirine-based approaches in proteome-wide cross-linking analyses. Here, we address this limitation by leveraging DizPK, a diazirine-containing lysine analog with a dedicated MS-cleavable urea functionality. We demonstrate proteome-wide incorporation of DizPK in Escherichia coli via stochastic orthogonal recoding of translation and subsequent identification of photo-cross-linked peptides to map protein\u2013protein interactions under physiological conditions. We find that the resulting approach can provide high-resolution structural information associated with transient biological processes.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00388","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T13:02:11Z","timestamp":1787403731000},"page":"4870-4887","source":"Crossref","is-referenced-by-count":0,"title":["Global Incorporation\nof a Photo-Cross-Linking Amino\nAcid to Probe the Protein Interactome under Physiological Conditions"],"prefix":"10.1021","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1102-8602","authenticated-orcid":true,"given":"Piyoosh","family":"Sharma","sequence":"first","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2431-1917","authenticated-orcid":true,"given":"Divya","family":"Yadav","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneliese M.","family":"Faustino","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Manriquez-Sandoval","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Wagner","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen , , ,","place":["Munich, Germany, 81375"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7898-2831","authenticated-orcid":true,"given":"Thomas","family":"Carell","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universita\u0308t Mu\u0308nchen , , ,","place":["Munich, Germany, 81375"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2494-2193","authenticated-orcid":true,"given":"Stephen D.","family":"Fried","sequence":"additional","affiliation":[{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]},{"name":"Johns Hopkins University , , , ,","place":["Baltimore, Maryland, United States, 21218"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"issue":"11","key":"2026090409134666600_cit1","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1016\/j.chempr.2019.08.020","article-title":"Genetically Encoded Residue-Selective Photo-Crosslinker\nto Capture Protein-Protein Interactions in Living Cells","volume":"5","author":"Hu","year":"2019","journal-title":"Chem"},{"issue":"4","key":"2026090409134666600_cit2","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.str.2022.02.004","article-title":"Exploring Protein-Protein Interactions at the Proteome\nLevel","volume":"30","author":"Elhabashy","year":"2022","journal-title":"Structure"},{"issue":"1","key":"2026090409134666600_cit3","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cbpa.2012.10.034","article-title":"Photocrosslinking\nApproaches to Interactome\nMapping","volume":"17","author":"Pham","year":"2013","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"16","key":"2026090409134666600_cit4","doi-asserted-by":"publisher","first-page":"2833","DOI":"10.1002\/pmic.200700131","article-title":"Methods for\nthe Detection and Analysis\nof Protein\u2013Protein Interactions","volume":"7","author":"Bergga\u030ard","year":"2007","journal-title":"Proteomics"},{"issue":"6","key":"2026090409134666600_cit5","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1039\/B803218A","article-title":"Photocrosslinkers\nIlluminate Interactions\nin Living Cells","volume":"4","author":"Tanaka","year":"2008","journal-title":"Mol. Biosyst."},{"issue":"2","key":"2026090409134666600_cit6","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1006\/jmbi.1993.1162","article-title":"Phenyl-Azide-Mediated\nPhotocrosslinking Analysis of\nCro-DNA Interaction","volume":"230","author":"Chen","year":"1993","journal-title":"J. Mol. Biol."},{"issue":"17","key":"2026090409134666600_cit7","doi-asserted-by":"publisher","first-page":"11020","DOI":"10.1073\/pnas.172226299","article-title":"Addition\nof a Photocrosslinking Amino Acid to the Genetic Code of Escherichia\nColi","volume":"99","author":"Chin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"26","key":"2026090409134666600_cit8","doi-asserted-by":"publisher","first-page":"8068","DOI":"10.1021\/ja072013j","article-title":"Covalent Capture\nof Phospho-Dependent Protein Oligomerization by Site-Specific Incorporation\nof a Diazirine Photo-Cross-Linker","volume":"129","author":"Vila-Perello\u0301","year":"2007","journal-title":"J. Am. Chem.\nSoc."},{"issue":"47","key":"2026090409134666600_cit9","doi-asserted-by":"publisher","first-page":"14560","DOI":"10.1021\/ja076250y","article-title":"Photo-Leucine Incorporation\nReveals the Target of a Cyclodepsipeptide Inhibitor of Cotranslational\nTranslocation","volume":"129","author":"MacKinnon","year":"2007","journal-title":"J. Am. Chem. Soc."},{"issue":"17","key":"2026090409134666600_cit10","doi-asserted-by":"publisher","first-page":"6078","DOI":"10.1021\/jacs.7b02615","article-title":"Genetically Encoded\n2-Aryl-5-Carboxytetrazoles\nfor Site-Selective Protein Photo-Cross-Linking","volume":"139","author":"Tian","year":"2017","journal-title":"J. Am. Chem. Soc."},{"issue":"16","key":"2026090409134666600_cit11","doi-asserted-by":"publisher","first-page":"6945","DOI":"10.1021\/acs.jmedchem.7b01561","article-title":"Fishing for Drug Targets: A Focus on Diazirine Photoaffinity\nProbe Synthesis","volume":"61","author":"Hill","year":"2018","journal-title":"J. Med. Chem."},{"issue":"8","key":"2026090409134666600_cit12","doi-asserted-by":"publisher","first-page":"4405","DOI":"10.1021\/cr1002722","article-title":"Aliphatic\nDiazirines as Photoaffinity Probes for Proteins: Recent Developments","volume":"111","author":"Das","year":"2011","journal-title":"Chem. Rev."},{"issue":"19","key":"2026090409134666600_cit13","doi-asserted-by":"publisher","first-page":"4885","DOI":"10.1002\/chem.201805004","article-title":"Recent Applications of Diazirines in Chemical Proteomics","volume":"25","author":"Halloran","year":"2019","journal-title":"Chem.\u2500Eur. J."},{"key":"2026090409134666600_cit14","doi-asserted-by":"publisher","first-page":"112151","DOI":"10.1016\/j.ejmech.2020.112151","article-title":"Activity-Based Protein\nProfiling: Recent Advances in Medicinal Chemistry","volume":"191","author":"Deng","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"17","key":"2026090409134666600_cit15","doi-asserted-by":"publisher","first-page":"6691","DOI":"10.1021\/jacs.1c02509","article-title":"Labeling Preferences of Diazirines\nwith Protein Biomolecules","volume":"143","author":"West","year":"2021","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"2026090409134666600_cit16","doi-asserted-by":"publisher","first-page":"6060","DOI":"10.1038\/s41467-024-50315-y","article-title":"Dissecting Diazirine\nPhoto-Reaction Mechanism for Protein Residue-Specific Cross-Linking\nand Distance Mapping","volume":"15","author":"Jiang","year":"2024","journal-title":"Nat. Commun."},{"issue":"4","key":"2026090409134666600_cit17","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1021\/acs.analchem.7b04915","article-title":"Carboxyl-Photo-Reactive\nMS-Cleavable Cross-Linkers: Unveiling a Hidden Aspect of Diazirine-Based\nReagents","volume":"90","author":"Iacobucci","year":"2018","journal-title":"Anal. 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Soc."},{"issue":"25","key":"2026090409134666600_cit21","doi-asserted-by":"publisher","first-page":"9445","DOI":"10.1021\/acs.analchem.2c05020","article-title":"Improved Cross-Linking\nCoverage for Protein Complexes Containing Low Levels of Lysine by\nUsing an Enrichable Photo-Cross-Linker","volume":"95","author":"Zhang","year":"2023","journal-title":"Anal.\nChem."},{"key":"2026090409134666600_cit22","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/s42003-025-09407-8","article-title":"Towards a Universal\nCross-Linking Mass Spectrometry Approach for Protein Structure Analysis\nwith Homo-Bi-Functional Photo-Activatable Cross-Linkers","volume":"9","author":"Ser","year":"2025","journal-title":"Commun. Biol."},{"issue":"4","key":"2026090409134666600_cit23","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nmeth752","article-title":"Photo-Leucine and Photo-Methionine\nAllow Identification of Protein-Protein Interactions in Living Cells","volume":"2","author":"Suchanek","year":"2005","journal-title":"Nat. Methods"},{"issue":"2","key":"2026090409134666600_cit24","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/nchembio.1990","article-title":"Photo-Lysine\nCaptures Proteins That Bind Lysine Post-Translational Modifications","volume":"12","author":"Yang","year":"2016","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"2026090409134666600_cit25","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41557-024-01663-1","article-title":"Spatiotemporal Protein\nInteractome Profiling through Condensation-Enhanced Photocrosslinking","volume":"17","author":"Li","year":"2025","journal-title":"Nat. Chem."},{"key":"2026090409134666600_cit26","doi-asserted-by":"publisher","first-page":"102357","DOI":"10.1016\/j.cbpa.2023.102357","article-title":"New Advances in Cross-Linking Mass Spectrometry toward\nStructural\nSystems Biology","volume":"76","author":"Yu","year":"2023","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"1","key":"2026090409134666600_cit27","doi-asserted-by":"publisher","first-page":"8537","DOI":"10.1038\/s41467-024-52844-y","article-title":"Cell Fixation Improves Performance of in Situ Crosslinking\nMass Spectrometry While Preserving Cellular Ultrastructure","volume":"15","author":"Michael","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"2026090409134666600_cit28","doi-asserted-by":"publisher","first-page":"5585","DOI":"10.1038\/s41467-025-60642-3","article-title":"Trioxane-Based MS-Cleavable Cross-Linking\nMass Spectrometry for Profiling\nMultimeric Interactions of Cellular Networks","volume":"16","author":"Yu","year":"2025","journal-title":"Nat. Commun."},{"issue":"8","key":"2026090409134666600_cit29","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/s42256-024-00873-z","article-title":"Integrated Structure\nPrediction of\nProtein\u2013Protein Docking with Experimental Restraints Using\nColabDock","volume":"6","author":"Feng","year":"2024","journal-title":"Nat. Mach. Intell."},{"issue":"1","key":"2026090409134666600_cit30","doi-asserted-by":"publisher","first-page":"7866","DOI":"10.1038\/s41467-024-51771-2","article-title":"Modelling Protein Complexes with Crosslinking Mass\nSpectrometry and Deep Learning","volume":"15","author":"Stahl","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"2026090409134666600_cit31","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1038\/s42003-025-08783-5","article-title":"Distance-AF\nImproves Predicted Protein\nStructure Models by AlphaFold2 with User-Specified Distance Constraints","volume":"8","author":"Zhang","year":"2025","journal-title":"Commun. Biol."},{"issue":"3","key":"2026090409134666600_cit32","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nrm3286","article-title":"Designer Proteins:\nApplications of Genetic Code Expansion\nin Cell Biology","volume":"13","author":"Davis","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026090409134666600_cit33","doi-asserted-by":"publisher","first-page":"1373250","DOI":"10.3389\/fgene.2024.1373250","article-title":"TRNA Engineering Strategies for Genetic\nCode Expansion","volume":"15","author":"Kim","year":"2024","journal-title":"Front. Genet."},{"issue":"3","key":"2026090409134666600_cit34","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1039\/C0SC00373E","article-title":"Genetically\nEncoding an Aliphatic Diazirine for Protein Photocrosslinking","volume":"2","author":"Chou","year":"2011","journal-title":"Chem. Sci."},{"issue":"1\u20132","key":"2026090409134666600_cit35","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/cbic.201900559","article-title":"A Genetically Encoded\nDiazirine Analogue for RNA\u2013Protein Photo-crosslinking","volume":"21","author":"Dziuba","year":"2020","journal-title":"ChemBioChem"},{"issue":"10","key":"2026090409134666600_cit36","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nchembio.644","article-title":"A Genetically Incorporated Crosslinker\nReveals Chaperone Cooperation in Acid Resistance","volume":"7","author":"Zhang","year":"2011","journal-title":"Nat. Chem. Biol."},{"issue":"22","key":"2026090409134666600_cit37","doi-asserted-by":"publisher","first-page":"12498","DOI":"10.1021\/acs.chemrev.4c00181","article-title":"Noncanonical\nAmino Acid Tools and Their Application to Membrane Protein Studies","volume":"124","author":"De Faveri","year":"2024","journal-title":"Chem. Rev."},{"issue":"22","key":"2026090409134666600_cit38","doi-asserted-by":"publisher","first-page":"4052","DOI":"10.1002\/anie.200900683","article-title":"A Facile System\nfor Encoding Unnatural\nAmino Acids in Mammalian Cells","volume":"48","author":"Chen","year":"2009","journal-title":"Angew. Chem.,\nInt. Ed."},{"issue":"42","key":"2026090409134666600_cit39","doi-asserted-by":"publisher","first-page":"14819","DOI":"10.1021\/ja104609m","article-title":"Expanding the Genetic\nCode of Yeast for Incorporation of Diverse Unnatural Amino Acids via\na Pyrrolysyl-TRNA Synthetase\/TRNA Pair","volume":"132","author":"Hancock","year":"2010","journal-title":"J. Am.\nChem. Soc."},{"issue":"3","key":"2026090409134666600_cit40","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.cbpa.2011.03.007","article-title":"The Pyrrolysine\nTranslational Machinery as a Genetic-Code\nExpansion Tool","volume":"15","author":"Fekner","year":"2011","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"2","key":"2026090409134666600_cit41","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1021\/acs.chemrev.4c00216","article-title":"Genetic Code Expansion:\nRecent Developments and Emerging Applications","volume":"125","author":"Huang","year":"2025","journal-title":"Chem. Rev."},{"issue":"12","key":"2026090409134666600_cit42","doi-asserted-by":"publisher","first-page":"7055","DOI":"10.1039\/C6SC02615J","article-title":"A Genetically\nEncoded Multifunctional Unnatural Amino\nAcid for Versatile Protein Manipulations in Living Cells","volume":"7","author":"Ge","year":"2016","journal-title":"Chem. Sci."},{"issue":"6","key":"2026090409134666600_cit43","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.bbapap.2014.03.002","article-title":"Pyrrolysyl-TRNA Synthetase: An Ordinary\nEnzyme but an Outstanding Genetic Code Expansion Tool","volume":"1844","author":"Wan","year":"2014","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"2026090409134666600_cit200","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nchembio.644","article-title":"A Genetically\nIncorporated Crosslinker Reveals Chaperone Cooperation in Acid Resistance","volume":"7","author":"Zhang","year":"2011","journal-title":"Nat. Chem. Biol."},{"issue":"7","key":"2026090409134666600_cit44","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.tim.2012.03.001","article-title":"Chaperone-Dependent\nMechanisms for Acid Resistance in Enteric Bacteria","volume":"20","author":"Hong","year":"2012","journal-title":"Trends Microbiol."},{"issue":"2","key":"2026090409134666600_cit45","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1093\/nar\/gkad1188","article-title":"TRNA Shape\nIs an Identity Element for an Archaeal Pyrrolysyl-TRNA Synthetase\nfrom the Human Gut","volume":"52","author":"Krahn","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"2026090409134666600_cit46","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cbpa.2014.07.001","article-title":"Genetic\nCode Expansion and Bioorthogonal\nLabelling Enables Cell Specific Proteomics in an Animal","volume":"21","author":"Elliott","year":"2014","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"5","key":"2026090409134666600_cit47","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nbt.2860","article-title":"Proteome Labeling and Protein Identification in Specific\nTissues and at Specific Developmental Stages in an Animal","volume":"32","author":"Elliott","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"7","key":"2026090409134666600_cit48","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.chembiol.2016.05.018","article-title":"Tagging\nand Enriching Proteins Enables Cell-Specific Proteomics","volume":"23","author":"Elliott","year":"2016","journal-title":"Cell Chem. Biol."},{"key":"2026090409134666600_cit49","first-page":"199","article-title":"BONCAT: Metabolic\nLabeling, Click Chemistry, and Affinity Purification of Newly Synthesized\nProteomes","volume-title":"Site-Specific Protein Labeling:\nMethods and Protocols","author":"Landgraf","year":"2014"},{"issue":"25","key":"2026090409134666600_cit50","doi-asserted-by":"publisher","first-page":"9482","DOI":"10.1073\/pnas.0601637103","article-title":"Selective\nIdentification of Newly Synthesized Proteins in Mammalian Cells Using\nBioorthogonal Noncanonical Amino Acid Tagging (BONCAT)","volume":"103","author":"Dieterich","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"2026090409134666600_cit51","doi-asserted-by":"publisher","first-page":"3367","DOI":"10.1038\/s41467-023-39063-7","article-title":"THRONCAT: Metabolic Labeling of Newly Synthesized Proteins\nUsing a Bioorthogonal Threonine Analog","volume":"14","author":"Ignacio","year":"2023","journal-title":"Nat.\nCommun."},{"issue":"15","key":"2026090409134666600_cit52","doi-asserted-by":"publisher","first-page":"10236","DOI":"10.1021\/acs.analchem.9b02372","article-title":"Simple Cross-Linking\/Mass\nSpectrometry Workflow for Studying System-Wide Protein Interactions","volume":"91","author":"Go\u0308tze","year":"2019","journal-title":"Anal. Chem."},{"issue":"23","key":"2026090409134666600_cit53","doi-asserted-by":"publisher","first-page":"8059","DOI":"10.1021\/ac0613840","article-title":"Collision-Induced Dissociative Chemical\nCross-Linking\nReagents and Methodology: Applications to Protein Structural Characterization\nUsing Tandem Mass Spectrometry Analysis","volume":"78","author":"Soderblom","year":"2006","journal-title":"Anal.\nChem."},{"issue":"22","key":"2026090409134666600_cit54","doi-asserted-by":"publisher","first-page":"7779","DOI":"10.1021\/acs.analchem.1c05266","article-title":"Improved Peptide Backbone Fragmentation Is the Primary\nAdvantage of MS-Cleavable Crosslinkers","volume":"94","author":"Kolbowski","year":"2022","journal-title":"Anal.\nChem."},{"issue":"22","key":"2026090409134666600_cit55","doi-asserted-by":"publisher","first-page":"6390","DOI":"10.1002\/anie.201709559","article-title":"Cross-linking\/Mass\nSpectrometry for Studying Protein Structures and Protein\u2013Protein\nInteractions: Where Are We Now and Where Should We Go from Here?","volume":"57","author":"Sinz","year":"2018","journal-title":"Angew. 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