{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:55:12Z","timestamp":1790949312387,"version":"4.1.0"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Gujarat State Biotechnology Mission (GSBTM)","award":["GSBTM\/RSS\/e-file\/30\/2024\/0021\/05258322"],"award-info":[{"award-number":["GSBTM\/RSS\/e-file\/30\/2024\/0021\/05258322"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Breast cancer cases are rising annually across the globe, with treatment options limited and slim survival chances at the end stage of cancer; the need for an early diagnosis is crucial. The present study aims to explore a noninvasive method for breast cancer detection by analyzing urine collected from patients. In this preliminary study, LC-MS-based profiling has been employed on the proteins in urine samples from Gujarat-based breast cancer patients to find potential diagnostic biomarkers. Differential analysis using limma with Benjamini\u2013Hochberg correction revealed 57 proteins that were upregulated in breast cancer, while 61 proteins were significantly downregulated (p-value \u2264 0.05, FC \u2265 2). ROC curve analysis yielded AUC values above 0.7 for candidate proteins, and functional enrichment analysis showed involvement of PI3K\/AKT signaling, phosphoinositide metabolism, and RNA processing pathways. Based on FDR-controlled differential abundance, individual ROC performance, and biological relevance, TMC5, SFPQ, SLC27A5, PLCH2, SPG11, and INPP4B were prioritized as exploratory candidate proteins. These proteins demonstrated potential as noninvasive urinary biomarkers for detection of breast cancer, requiring targeted validation in an independent, clinically characterized cohort before investigating their diagnostic utility.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00497","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:01:46Z","timestamp":1788778906000},"page":"5512-5522","source":"Crossref","is-referenced-by-count":0,"title":["Urinary Proteomics\nof Breast Cancer Patients from\nGujarat for the Identification of Potential Biomarkers"],"prefix":"10.1021","volume":"25","author":[{"given":"Nandini","family":"Patel","sequence":"first","affiliation":[{"name":"Gujarat Biotechnology Research Centre (GBRC) , 6th Floor, MS Building, GH Road, Sector-11 , , ,","place":["Gandhinagar, Gujarat, India, 382011"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Doshi","sequence":"additional","affiliation":[{"name":"Gujarat Biotechnology Research Centre (GBRC) , 6th Floor, MS Building, GH Road, Sector-11 , , ,","place":["Gandhinagar, Gujarat, India, 382011"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Shah","sequence":"additional","affiliation":[{"name":"Civil Hospital Campus , , Asarwa, , ,","place":["Ahmedabad, Gujarat, India, 380016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Pandya","sequence":"additional","affiliation":[{"name":"Civil Hospital Campus , , Asarwa, , ,","place":["Ahmedabad, Gujarat, India, 380016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Patidar","sequence":"additional","affiliation":[{"name":"Gujarat Biotechnology Research Centre (GBRC) , 6th Floor, MS Building, GH Road, Sector-11 , , ,","place":["Gandhinagar, Gujarat, India, 382011"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruvi","family":"Dixit","sequence":"additional","affiliation":[{"name":"Civil Hospital Campus , , Asarwa, , ,","place":["Ahmedabad, Gujarat, India, 380016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Patel","sequence":"additional","affiliation":[{"name":"Gujarat Biotechnology Research Centre (GBRC) , 6th Floor, MS Building, GH Road, Sector-11 , , ,","place":["Gandhinagar, Gujarat, India, 382011"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal","family":"Bagatharia","sequence":"additional","affiliation":[{"name":"Gujarat Biotechnology Research Centre (GBRC) , 6th Floor, MS Building, GH Road, Sector-11 , , ,","place":["Gandhinagar, Gujarat, India, 382011"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1414-6265","authenticated-orcid":true,"given":"Ishan","family":"Raval","sequence":"additional","affiliation":[{"name":"Gujarat Biotechnology Research Centre (GBRC) , 6th Floor, MS Building, GH Road, Sector-11 , , ,","place":["Gandhinagar, Gujarat, India, 382011"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"issue":"3","key":"2026100208415010300_cit1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global Cancer Statistics 2022: GLOBOCAN\nEstimates of Incidence and Mortality Worldwide for 36 Cancers in 185\nCountries","volume":"74","author":"Bray","year":"2024","journal-title":"Ca-Cancer J. Clin."},{"key":"2026100208415010300_cit2","doi-asserted-by":"publisher","first-page":"1622954","DOI":"10.3389\/fpubh.2025.1622954","article-title":"Global Burden\nand Projections of\nBreast Cancer Incidence and Mortality to 2050: A Comprehensive Analysis\nof GLOBOCAN Data","volume":"13","author":"Freihat","year":"2025","journal-title":"Front Public Health"},{"issue":"8","key":"2026100208415010300_cit3","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.27805","article-title":"Cancer Incidence\nand Mortality Across 43 Cancer Registries in India","volume":"8","author":"Mathur","year":"2025","journal-title":"JAMA Netw Open."},{"issue":"2","key":"2026100208415010300_cit4","doi-asserted-by":"publisher","first-page":"80","DOI":"10.17849\/insm-50-2-80-122.1","article-title":"Breast Cancer: 20-Year\nComparative Mortality and Survival\nAnalysis by Age, Sex, Race\/Ethnicity, Stage, Grade, Disease Duration,\nSelected ICD-O-3 Oncophenotypes, and Cohort Entry Time-Period","volume":"50","author":"Milano","year":"2023","journal-title":"J. Insur. Med."},{"key":"2026100208415010300_cit5","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s11296-005-0002-9","article-title":"CLINICAL REVIEW\nDetecting Breast Cancer: Evidence for the Significance of the Mostly\nUsed Methods","volume":"1","author":"Lenz","year":"2005","journal-title":"Eur. Clinics Obstet. Gynaecol."},{"issue":"1","key":"2026100208415010300_cit6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s10549-016-3695-1","article-title":"Breast Cancer Screening Using Tomosynthesis\nin Combination with Digital Mammography Compared to Digital Mammography\nAlone: A Cohort Study within the PROSPR Consortium","volume":"156","author":"Conant","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"issue":"7","key":"2026100208415010300_cit7","doi-asserted-by":"publisher","first-page":"166","DOI":"10.22159\/AJPCR.2024V17I7.51945","article-title":"ROLE OF\nULTRASOUND AND MAMMOGRAPHY\nFOR EVALUATION OF BREAST MASSES: A COMPARATIVE OBSERVATIONAL STUDY","volume":"17","author":"Nihal","year":"2024","journal-title":"Asian J. Pharm. Clin. Res."},{"issue":"2","key":"2026100208415010300_cit8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s10911-006-9018-0","article-title":"A Review of Breast\nUltrasound","volume":"11","author":"Sehgal","year":"2006","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"issue":"10","key":"2026100208415010300_cit9","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1002\/ijc.34434","article-title":"Urine Biomarkers in\nCancer Detection: A Systematic Review of Preanalytical Parameters\nand Applied Methods","volume":"152","author":"Jordaens","year":"2023","journal-title":"Int. J. Cancer"},{"issue":"1","key":"2026100208415010300_cit10","doi-asserted-by":"publisher","first-page":"22","DOI":"10.11613\/BM.2015.003","article-title":"Advances in\nUrinary Protein Biomarkers for Urogenital\nand Non-Urogenital Pathologies","volume":"25","author":"Pedroza-Diaz","year":"2015","journal-title":"Biochem. Med."},{"issue":"11","key":"2026100208415010300_cit11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0291574","article-title":"Proteomic\nProfiling of Urinary Extracellular\nVesicles Differentiates Breast Cancer Patients from Healthy Women","volume":"18","author":"Jeanmard","year":"2023","journal-title":"PLoS One"},{"issue":"11","key":"2026100208415010300_cit12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141876","article-title":"Proteomic Analysis\nof Urine to Identify Breast Cancer Biomarker Candidates\nUsing a Label-Free LC-MS\/MS Approach","volume":"10","author":"Beretov","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"2026100208415010300_cit13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12014-020-09283-w","article-title":"Recent Advances\nin Mass Spectrometry\nBased Clinical Proteomics: Applications to Cancer Research","volume":"17","author":"Macklin","year":"2020","journal-title":"Clin. Proteomics"},{"issue":"12","key":"2026100208415010300_cit14","doi-asserted-by":"publisher","first-page":"5932","DOI":"10.1021\/acs.jproteome.5c00229","article-title":"The\nUrinary Proteome Differs with the Presence and Type of Breast Cancer","volume":"24","author":"Zainurin","year":"2025","journal-title":"J. Proteome Res."},{"key":"2026100208415010300_cit15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/978-1-4939-6747-6_23","article-title":"Data Conversion with ProteoWizard\nMsConvert","volume":"1550","author":"Adusumilli","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"2026100208415010300_cit16","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/mas.21540","article-title":"The Skyline Ecosystem:\nInformatics for Quantitative\nMass Spectrometry Proteomics","volume":"39","author":"Pino","year":"2020","journal-title":"Mass Spectrom.\nRev."},{"issue":"1","key":"2026100208415010300_cit17","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and\nPowerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R\nStat Soc. Series B Stat. Methodol."},{"issue":"7","key":"2026100208415010300_cit18","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKV007","article-title":"Limma Powers Differential\nExpression Analyses for RNA-Sequencing\nand Microarray Studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"Web Server issue","key":"2026100208415010300_cit19","doi-asserted-by":"publisher","first-page":"W652","DOI":"10.1093\/NAR\/GKP356","article-title":"MetaboAnalyst: A\nWeb Server for Metabolomic Data Analysis and Interpretation","volume":"37","author":"Xia","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"2026100208415010300_cit20","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.922","article-title":"Using ExpressAnalyst\nfor Comprehensive Gene Expression Analysis in Model and Non-Model\nOrganisms","volume":"3","author":"Ewald","year":"2023","journal-title":"Curr. Protoc."},{"issue":"1","key":"2026100208415010300_cit21","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene\nOntology: Tool for the Unification of\nBiology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"issue":"1","key":"2026100208415010300_cit22","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1093\/nar\/gkg115","article-title":"PANTHER: A\nBrowsable Database of Gene Products Organized by Biological Function,\nUsing Curated Protein Family and Subfamily Classification","volume":"31","author":"Thomas","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"2026100208415010300_cit23","doi-asserted-by":"publisher","first-page":"810864","DOI":"10.3389\/fmolb.2021.810864","article-title":"TMC5 Is Highly Expressed\nin Human Cancers and Corelates to Prognosis and Immune Cell Infiltration:\nA Comprehensive Bioinformatics Analysis","volume":"8","author":"Zhang","year":"2022","journal-title":"Front.\nMol. Biosci."},{"key":"2026100208415010300_cit24","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2025.805","article-title":"Silence of\nTransmembrane Channel-Like 5 Inhibits Cell\nProliferation, Migration, and Invasion While Promoting Apoptosis Via\nDeactivating the AKT Pathway in Breast Cancer","author":"Wan","year":"2025","journal-title":"Cancer Res. Treat."},{"issue":"1","key":"2026100208415010300_cit25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-025-16610-4","article-title":"The Expression of Transmembrane Channel-like\n5 in Gastric Cancer and Its Impact on Tumor Progression","volume":"15","author":"Wei","year":"2025","journal-title":"Sci. Rep."},{"issue":"3","key":"2026100208415010300_cit26","doi-asserted-by":"publisher","first-page":"94091","DOI":"10.5306\/wjco.v16.i3.94091","article-title":"Transmembrane Channel-like\n5 Drives Hepatocellular Carcinoma Progression by Regulating Epithelial-Mesenchymal\nTransition","volume":"16","author":"Li","year":"2025","journal-title":"World J. Clin. Oncol."},{"issue":"1","key":"2026100208415010300_cit27","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1172\/JCI93707","article-title":"Proapoptotic\nPUMA Targets Stem-like Breast Cancer Cells to Suppress Metastasis","volume":"128","author":"Sun","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"4","key":"2026100208415010300_cit28","doi-asserted-by":"publisher","first-page":"101253","DOI":"10.1016\/j.jbc.2021.101253","article-title":"FBXL20\nPromotes Breast Cancer Malignancy by Inhibiting Apoptosis through\nDegradation of PUMA and BAX","volume":"297","author":"Manne","year":"2021","journal-title":"J. Biol. Chem."},{"key":"2026100208415010300_cit29","doi-asserted-by":"publisher","first-page":"8766","DOI":"10.3390\/ijms25168766","article-title":"Serum Splicing\nFactor Proline-and Glutamine-Rich Is a Diagnostic Marker for Non-Small-Cell\nLung Cancer and Other Solid Cancers","author":"Yang","year":"2024"},{"key":"2026100208415010300_cit30","doi-asserted-by":"publisher","first-page":"zcac027","DOI":"10.1093\/narcan\/zcac027","article-title":"SFPQ promotes RAS-mutant cancer cell growth\nby modulating 5\u2032-UTR mediated translational control of CK1\u03b1","volume":"4","author":"Kok","year":"2022","journal-title":"NAR Cancer"},{"issue":"18","key":"2026100208415010300_cit31","doi-asserted-by":"publisher","first-page":"4654","DOI":"10.3390\/cancers13184654","article-title":"Metastasis Risk Assessment\nUsing\nBAG2 Expression by Cancer-Associated Fibroblast and Tumor Cells in\nPatients with Breast Cancer","volume":"13","author":"Yoon","year":"2021","journal-title":"Cancers 2021"},{"issue":"1","key":"2026100208415010300_cit32","doi-asserted-by":"publisher","first-page":"339","DOI":"10.7150\/thno.78492","article-title":"BAG2 Drives\nChemoresistance of Breast Cancer by Exacerbating Mutant P53 Aggregate","volume":"13","author":"Huang","year":"2023","journal-title":"Theranostics"},{"issue":"2","key":"2026100208415010300_cit33","doi-asserted-by":"publisher","first-page":"10761","DOI":"10.1080\/21655979.2021.2003130","article-title":"Tetraspanin\n1 (TSPAN1) Promotes Growth and Transferation of Breast Cancer Cells\nvia Mediating PI3K\/Akt Pathway","volume":"12","author":"Wu","year":"2021","journal-title":"Bioengineered"},{"issue":"8","key":"2026100208415010300_cit34","doi-asserted-by":"publisher","first-page":"4159","DOI":"10.21037\/tcr-24-409","article-title":"TSPAN1 Overexpression\nas an Indicator of Poor Prognosis in Estrogen Receptor-Positive Breast\nCancer","volume":"13","author":"Liu","year":"2024","journal-title":"Transl. Cancer Res."},{"issue":"1","key":"2026100208415010300_cit35","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1186\/s12885-020-07184-7","article-title":"Low Dose Environmental Radon Exposure\nand Breast Tumor Gene Expression","volume":"20","author":"Peng","year":"2020","journal-title":"BMC Cancer"},{"key":"2026100208415010300_cit36","doi-asserted-by":"publisher","first-page":"1577114","DOI":"10.3389\/fonc.2025.1577114","article-title":"PLCH1 Overexpression Promotes Breast\nCancer Progression and Predicts\nPoor Prognosis through the ERK1\/2-EGR1 Axis","volume":"15","author":"Li","year":"2025","journal-title":"Front. Oncol."},{"key":"2026100208415010300_cit37","doi-asserted-by":"publisher","first-page":"106293","DOI":"10.1016\/j.nbd.2023.106293","article-title":"Liver-X-Receptor\nAgonists Rescue Axonal Degeneration in SPG11-Deficient\nNeurons via Regulating Cholesterol Trafficking","volume":"187","author":"Chai","year":"2023","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"2026100208415010300_cit38","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3390\/biomedicines10020234","article-title":"Decreased SLC27A5 Suppresses Lipid\nSynthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular\nCarcinoma","volume":"10","author":"Wang","year":"2022","journal-title":"Biomedicines"},{"issue":"4","key":"2026100208415010300_cit39","doi-asserted-by":"publisher","first-page":"101488","DOI":"10.1016\/j.gendis.2024.101488","article-title":"SLC27A5 Inhibits\nCancer Stem Cells by Inducing Alternative Polyadenylation\nof METTL14 in Hepatocellular Carcinoma","volume":"12","author":"Tang","year":"2025","journal-title":"Genes\nDis."},{"issue":"51","key":"2026100208415010300_cit40","doi-asserted-by":"publisher","first-page":"22231","DOI":"10.1073\/pnas.1015245107","article-title":"Inositol Polyphosphate 4-Phosphatase II Regulates PI3K\/Akt Signaling\nand Is Lost in Human Basal-like Breast Cancers","volume":"107","author":"Fedele","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"2026100208415010300_cit41","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1158\/1541-7786.MCR-16-0183","article-title":"INPP4B and PTEN Loss Leads to PI-3,4-P2\nAccumulation\nand Inhibition of PI3K in TNBC","volume":"15","author":"Reed","year":"2017","journal-title":"Mol. Cancer\nRes."},{"issue":"1","key":"2026100208415010300_cit42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-23241-6","article-title":"INPP4B Promotes\nPI3K\u03b1-Dependent Late Endosome Formation and Wnt\/\u03b2-Catenin\nSignaling in Breast Cancer","volume":"12","author":"Rodgers","year":"2021","journal-title":"Nat. Commun."},{"issue":"10","key":"2026100208415010300_cit43","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1158\/0008-5472.CAN-14-3303","article-title":"Manic Fringe Promotes\na Claudin-Low Breast Cancer Phenotype through\nNotch-Mediated PIK3CG Induction","volume":"75","author":"Zhang","year":"2015","journal-title":"Cancer Res."},{"key":"2026100208415010300_cit44","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.2147\/CMAR.S250171","article-title":"Targeting PIK3CG in\nCombination with Paclitaxel as a Potential Therapeutic Regimen in\nClaudin-Low Breast Cancer","volume":"12","author":"Chang","year":"2020","journal-title":"Cancer Manage. Res."},{"issue":"13","key":"2026100208415010300_cit45","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1158\/0008-5472.CAN-19-3033","article-title":"RNF168-Mediated Ubiquitin\nSignaling Inhibits the Viability of BRCA1-Null Cancers","volume":"80","author":"Krais","year":"2020","journal-title":"Cancer Res."},{"issue":"9","key":"2026100208415010300_cit46","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.1111\/jcmm.13694","article-title":"RNF168 Facilitates Oestrogen Receptor a Transcription\nand Drives Breast Cancer Proliferation","volume":"22","author":"Liu","year":"2018","journal-title":"J. Cell.\nMol. Med."},{"issue":"3","key":"2026100208415010300_cit47","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB Signaling:\nNavigating the Network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"issue":"4","key":"2026100208415010300_cit48","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","article-title":"The PI3K Pathway\nin Human Disease","volume":"170","author":"Fruman","year":"2017","journal-title":"Cell"},{"issue":"1","key":"2026100208415010300_cit49","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/nrc3860","article-title":"PI3K in Cancer: Divergent Roles of\nIsoforms, Modes of Activation and Therapeutic Targeting","volume":"15","author":"Thorpe","year":"2015","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"2026100208415010300_cit50","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ccr.2009.06.006","article-title":"Evidence That Inositol Polyphosphate 4-Phosphatase\nType II Is a Tumor Suppressor That Inhibits PI3K Signaling","volume":"16","author":"Gewinner","year":"2009","journal-title":"Cancer Cell"},{"issue":"17","key":"2026100208415010300_cit51","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1002\/pmic.201600015","article-title":"Urinary Proteome Alterations in HER2 Enriched Breast\nCancer Revealed by Multipronged Quantitative Proteomics","volume":"16","author":"Gajbhiye","year":"2016","journal-title":"Proteomics"},{"issue":"12","key":"2026100208415010300_cit52","doi-asserted-by":"publisher","first-page":"5932","DOI":"10.1021\/acs.jproteome.5c00229","article-title":"The\nUrinary Differs with the Presence and Type of Breast Cancer","volume":"24","author":"Zainurin","year":"2025","journal-title":"J. Proteome Res."}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.6c00497","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/10\/5512\/68401609\/acs.jproteome.6c00497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/10\/5512\/68401609\/acs.jproteome.6c00497.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:10:49Z","timestamp":1790946649000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jprobs\/article\/25\/10\/5512\/5422254\/Urinary-Proteomics-of-Breast-Cancer-Patients-from"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,7]]},"published-print":{"date-parts":[[2026,10,2]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.6c00497","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]}}}