{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:53:29Z","timestamp":1790949209524,"version":"4.1.0"},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A6A1A03044296"],"award-info":[{"award-number":["2021R1A6A1A03044296"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Melanoma is a highly aggressive skin cancer with strong metastatic potential and frequent chemoresistance. Aberrant N-glycosylation plays a critical role in tumor progression and drug resistance; however, cisplatin-induced alterations in melanoma surface N-glycans remain poorly understood. Thus, this study aimed to perform comprehensive structural and quantitative profiling of surface N-glycans in G-361 (low metastatic potential), A375P (moderate), and SK-MEL-28 (high) melanoma cells following cisplatin treatment using LC\u2013MS\/MS. A total of 25, 39, and 28 surface N-glycans were identified in untreated G-361, A375P, and SK-MEL-28 cells, respectively, whereas 40, 37, and 40 N-glycans were detected after cisplatin treatment. Absolute quantification revealed a marked increase in total N-glycan abundance in G-361 (3.2 to 8.4 pmol) and A375P (5.7 to 10.9 pmol), whereas SK-MEL-28 maintained homeostasis (3.9 to 4.0 pmol). Surface N-glycans were predominantly high-mannose and complex-type glycans with extensive sialylation and fucosylation. Cisplatin induced distinct cell line-specific remodeling: G-361 accumulated high-mannose glycans with reduced Neu5Gc-containing sialylation; A375P showed increased glycan branching and Neu5Ac-containing sialylation; and SK-MEL-28 maintained a stable glycan distribution but exhibited increased Neu5Gc-containing sialylation. These results demonstrate adaptive N-glycosylation responses to cisplatin in melanoma cells with distinct metastatic potentials and provide a glycomic framework for understanding cisplatin-associated glycan alterations.<\/jats:p>","DOI":"10.1021\/acs.jproteome.6c00603","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:02:05Z","timestamp":1790164925000},"page":"5584-5598","source":"Crossref","is-referenced-by-count":0,"title":["Structural and\nQuantitative Surface\n                    <i>N<\/i>\n                    -Glycomic Profiling\nof Cisplatin-Treated Melanoma Cells with\nDistinct Metastatic Potential"],"prefix":"10.1021","volume":"25","author":[{"given":"Siwon","family":"Kim","sequence":"first","affiliation":[{"name":"Graduate School of Chung-Ang University , , 84 Heukseok-ro, Dongjak-gu , ,","place":["Seoul, Republic of Korea, 06974"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuran","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School of Chung-Ang University , , 84 Heukseok-ro, Dongjak-gu , ,","place":["Seoul, Republic of Korea, 06974"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Graduate School of Chung-Ang University , , 84 Heukseok-ro, Dongjak-gu , ,","place":["Seoul, Republic of Korea, 06974"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chulmin","family":"Moon","sequence":"additional","affiliation":[{"name":"Graduate School of Chung-Ang University , , 84 Heukseok-ro, Dongjak-gu , ,","place":["Seoul, Republic of Korea, 06974"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daeun","family":"Eom","sequence":"additional","affiliation":[{"name":"Graduate School of Chung-Ang University , , 84 Heukseok-ro, Dongjak-gu , ,","place":["Seoul, Republic of Korea, 06974"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seojeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate School of Chung-Ang University , , 84 Heukseok-ro, Dongjak-gu , ,","place":["Seoul, Republic of Korea, 06974"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate School of Chung-Ang University , , 84 Heukseok-ro, Dongjak-gu , ,","place":["Seoul, Republic of Korea, 06974"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejin","family":"Park","sequence":"additional","affiliation":[{"name":"Graduate School of Chung-Ang University , , 84 Heukseok-ro, Dongjak-gu , ,","place":["Seoul, Republic of Korea, 06974"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeyong","family":"An","sequence":"additional","affiliation":[{"name":"Graduate School of Chung-Ang University , , 84 Heukseok-ro, Dongjak-gu , ,","place":["Seoul, Republic of Korea, 06974"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-4928","authenticated-orcid":true,"given":"Ha Hyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School of Chung-Ang University , , 84 Heukseok-ro, Dongjak-gu , ,","place":["Seoul, Republic of Korea, 06974"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"8","key":"2026100208421656800_cit1","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.3390\/cells10082136","article-title":"The role of glycosylation\nin melanoma progression","volume":"10","author":"De Vellis","year":"2021","journal-title":"Cells"},{"key":"2026100208421656800_cit2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1268479","article-title":"Advances in melanoma:\nepidemiology, diagnosis, and\nprognosis","volume":"10","author":"Waseh","year":"2023","journal-title":"Front. 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Rep."},{"issue":"1\u20132","key":"2026100208421656800_cit6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0304-3835(87)90209-6","article-title":"A simple quantitative\nassay for studying the invasive potential of high and low human metastatic\nvariants","volume":"38","author":"Hendrix","year":"1987","journal-title":"Cancer Lett."},{"issue":"1","key":"2026100208421656800_cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01886-1","article-title":"Glycosylation:\nmechanisms, biological\nfunctions and clinical implications","volume":"9","author":"He","year":"2024","journal-title":"Signal\nTransduction Targeted Ther."},{"issue":"23","key":"2026100208421656800_cit8","doi-asserted-by":"publisher","first-page":"35478","DOI":"10.18632\/oncotarget.8155","article-title":"Hallmarks of glycosylation in cancer","volume":"7","author":"Munkley","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"2026100208421656800_cit9","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1007\/s00262-005-0019-4","article-title":"Characterization of glycosylation\nand adherent properties of melanoma cell lines","volume":"55","author":"Laidler","year":"2006","journal-title":"Cancer Immunol. 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Immunol."},{"issue":"6","key":"2026100208421656800_cit47","doi-asserted-by":"publisher","first-page":"4228","DOI":"10.1074\/jbc.M412040200","article-title":"Mechanism\nof uptake\nand incorporation of the non-Human sialic acid N-glycolylneuraminic\nacid into human cells","volume":"280","author":"Bardor","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"34","key":"2026100208421656800_cit48","doi-asserted-by":"publisher","first-page":"28865","DOI":"10.1074\/jbc.M112.363549","article-title":"Metabolism\nof vertebrate amino sugars with N-glycolyl groups:\nelucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid","volume":"287","author":"Bergfeld","year":"2012","journal-title":"J. Biol.\nChem."}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.6c00603","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/10\/5584\/68615195\/acs.jproteome.6c00603.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jprobs\/article-pdf\/25\/10\/5584\/68615195\/acs.jproteome.6c00603.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:57:36Z","timestamp":1790945856000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jprobs\/article\/25\/10\/5584\/5436277\/Structural-and-Quantitative-Surface-N-Glycomic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":48,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,9,23]]},"published-print":{"date-parts":[[2026,10,2]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.6c00603","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]}}}