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A total of 73 and 69 proteins belonging to 15 snake venom protein families were identified in RVV B and RVV N, respectively, by MS\/MS search against Viperidae (taxid 8689) protein entries of the nonredundant NCBI database. The minor differences in venom composition of both the EI RV were established unequivocally by their biochemical and pharmacological properties and by SDS-PAGE, gel filtration chromatography, and LC-MS\/MS analyses. The composition of EI RVVs was well correlated with published reports on the pathophysiology of RV-envenomed patients from this part of the country. Venom\u2013antivenom cross-reactivity determined by ELISA, Western blotting, and antivenomics approaches demonstrated poor recognition of low molecular mass (&amp;lt;20 kDa) RVV proteins by commercial polyvalent antivenoms, which was substantiated by neutralization of RVV enzymes by antivenom.<\/jats:p>","DOI":"10.1021\/acs.jproteome.8b00291","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T05:27:49Z","timestamp":1529904469000},"page":"2819-2833","source":"Crossref","is-referenced-by-count":61,"title":["Proteomic Analysis\nand Immuno-Profiling of Eastern\nIndia Russell\u2019s Viper (\n                    <i>Daboia russelii<\/i>\n                    ) Venom:\nCorrelation between RVV Composition and Clinical Manifestations Post\nRV Bite"],"prefix":"10.1021","volume":"17","author":[{"given":"Bhargab","family":"Kalita","sequence":"first","affiliation":[{"name":"Tezpur University , , , ,","place":["Tezpur, Assam, India, 784028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparup","family":"Patra","sequence":"additional","affiliation":[{"name":"Tezpur University , , , ,","place":["Tezpur, Assam, India, 784028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Das","sequence":"additional","affiliation":[{"name":"Tezpur University , , , ,","place":["Tezpur, Assam, India, 784028"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-858X","authenticated-orcid":true,"given":"Ashis K.","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Tezpur University , , , ,","place":["Tezpur, Assam, India, 784028"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,6,25]]},"reference":[{"issue":"3","key":"2026081723125364200_cit1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0041-0101(88)90216-4","article-title":"Geographical variation in India in the composition\nand lethal potency of Russell\u2019s viper (Vipera russelli) venom","volume":"26","author":"Jayanthi","year":"1988","journal-title":"Toxicon"},{"issue":"6","key":"2026081723125364200_cit2","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/0035-9203(89)90311-8","article-title":"Snake venoms\nin science and clinical medicine. 1. Russell\u2019s viper: biology,\nvenom and treatment of bites","volume":"83","author":"Warrell","year":"1989","journal-title":"Trans. R. Soc.\nTrop. Med. Hyg."},{"issue":"2","key":"2026081723125364200_cit3","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0041-0101(99)00125-7","article-title":"Some biochemical properties\nof Russell\u2019s\nviper (Daboia russelli) venom from Eastern India:\ncorrelation with clinico-pathological manifestation in Russell\u2019s\nviper bite","volume":"38","author":"Mukherjee","year":"2000","journal-title":"Toxicon"},{"issue":"6","key":"2026081723125364200_cit4","first-page":"145","article-title":"Epidemiology of snake bite in the\ndistrict of Burdwan,\nWest Bengal","volume":"90","author":"Hati","year":"1992","journal-title":"J. Indian Med. Assoc"},{"key":"2026081723125364200_cit5","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.jprot.2015.08.017","article-title":"Functional venomics\nof the Sri Lankan Russell\u2019s\nviper (Daboia russelii) and its toxinological correlations","volume":"128","author":"Tan","year":"2015","journal-title":"J. Proteomics"},{"key":"2026081723125364200_cit6","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jprot.2016.06.001","article-title":"A proteomic analysis\nof Pakistan Daboia russelii russelii venom and assessment\nof potency\nof Indian polyvalent and monovalent antivenom","volume":"144","author":"Mukherjee","year":"2016","journal-title":"J. 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Venomous Anim.\nToxins Incl. Trop. Dis."},{"issue":"6","key":"2026081723125364200_cit29","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1002\/pro.2253","article-title":"Sequence-specific determination of\nprotein and peptide\nconcentrations by absorbance at 205 nm","volume":"22","author":"Anthis","year":"2013","journal-title":"Protein\nSci."},{"key":"2026081723125364200_cit30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-4939-6412-3_2","article-title":"Gel-Filtration Chromatography","volume-title":"Protein\nChromatography: Methods and Protocols","author":"O\u0301\u2019Fa\u0301ga\u0301in","year":"2017"},{"issue":"8","key":"2026081723125364200_cit31","doi-asserted-by":"publisher","first-page":"4152","DOI":"10.1021\/pr1003856","article-title":"Quantifying the impact of chimera\nMS\/MS spectra on peptide identification in large-scale proteomics\nstudies","volume":"9","author":"Houel","year":"2010","journal-title":"J. Proteome Res."},{"issue":"2","key":"2026081723125364200_cit32","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.jchromb.2006.08.038","article-title":"Purification\nand characterization of a low molecular weight multifunctional cytotoxic\nphospholipase A2 from Russell\u2019s viper venom","volume":"845","author":"Maity","year":"2007","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"2026081723125364200_cit33","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.cbpc.2014.12.001","article-title":"Biochemical and pharmacological characterization\nof a toxic fraction and its cytotoxin-like component isolated from\nRussell\u2019s viper (Daboia russelii russelii)\nvenom","volume":"168","author":"Thakur","year":"2015","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol.\nPharmacol."},{"key":"2026081723125364200_cit34","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ijbiomac.2014.02.058","article-title":"Characterization of a Kunitz-type\nprotease inhibitor peptide (Rusvikunin) purified from Daboia\nrusselii russelii venom","volume":"67","author":"Mukherjee","year":"2014","journal-title":"Int. J. 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Biol. 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Haemostasis"},{"issue":"7","key":"2026081723125364200_cit50","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.toxicon.2009.01.039","article-title":"Experimental pathophysiology of systemic\nalterations induced by Bothrops asper snake venom","volume":"54","author":"Gutierrez","year":"2009","journal-title":"Toxicon"},{"key":"2026081723125364200_cit51","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1201\/9781420008661.ch5","article-title":"Snake venom\nmetalloproteinases. Biological\nroles and participation in the pathophysiology of envenomation","author":"Escalante","year":"2009","journal-title":"Handbook of venoms and toxins of reptiles"},{"key":"2026081723125364200_cit52","first-page":"88","article-title":"Profile of snakebite envenoming in\nrural Maharashtra,\nIndia","volume":"56","author":"Bawaskar","year":"2008","journal-title":"J. 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