{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:18:55Z","timestamp":1788326335553,"version":"build-2803163510"},"reference-count":73,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100000836","name":"University of Liverpool","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100000836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Institute of Ageing and Chronic Disease, University of Liverpool","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ligaments are prone to injury and degeneration in humans and animals, however the healing potential of ligament is poor and current treatment options ineffective. Stem cell-based therapies hold potential for treatment of ligament injuries. This study aimed to characterize a ligament progenitor cell (LPC) population and to identify specific niche components which could promote the survival and function of LPCs. LPCs were isolated from canine cranial cruciate ligament and characterized for clonogenicity, multipotency and marker expression. The extracellular matrix (ECM) composition was characterized by the novel application of a metabolic labeling and mass spectrometry technique. LPCs demonstrated clonogenicity, multipotency, and stem cell marker expression. A number of different collagens, glycoproteins, and proteoglycans were identified in the LPC niche using proteomics. Metabolic labeling of cells demonstrated unique turnover profiles for distinct ECM protein groups, indicating the importance of certain niche components for LPC survival and function. The newly synthesized niche components identified in this study could be exploited to aid identification of LPCs and to promote their survival and function for potential ligament repair strategies.<\/jats:p>","DOI":"10.1021\/acs.jproteome.8b00933","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T21:59:23Z","timestamp":1548280763000},"page":"1328-1339","source":"Crossref","is-referenced-by-count":8,"title":["Identification\nand Characterization of Canine Ligament\nProgenitor Cells and Their Extracellular Matrix Niche"],"prefix":"10.1021","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-1547","authenticated-orcid":true,"given":"Katie J","family":"Lee","sequence":"first","affiliation":[{"name":"Institute of Ageing and Chronic Disease, University of Liverpool , , William Henry Duncan Building, 6 West Derby Street , , ,","place":["Liverpool, United Kingdom, L7 8TX"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eithne J","family":"Comerford","sequence":"additional","affiliation":[{"name":"Institute of Ageing and Chronic Disease, University of Liverpool , , William Henry Duncan Building, 6 West Derby Street , , ,","place":["Liverpool, United Kingdom, L7 8TX"]},{"name":"University of Liverpool , , Chester High Road , , ,","place":["Neston, United Kingdom, CH64 7TE"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M","family":"Simpson","sequence":"additional","affiliation":[{"name":"Institute of Integrative Biology, University of Liverpool , , ,","place":["Liverpool, United Kingdom, L69 7ZB"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D","family":"Clegg","sequence":"additional","affiliation":[{"name":"Institute of Ageing and Chronic Disease, University of Liverpool , , William Henry Duncan Building, 6 West Derby Street , , ,","place":["Liverpool, United Kingdom, L7 8TX"]},{"name":"University of Liverpool , , Chester High Road , , ,","place":["Neston, United Kingdom, CH64 7TE"]},{"name":"The MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) , ,","place":["Liverpool, United Kingdom, L7 8TX"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-1316","authenticated-orcid":true,"given":"Elizabeth G","family":"Canty-Laird","sequence":"additional","affiliation":[{"name":"Institute of Ageing and Chronic Disease, University of Liverpool , , William Henry Duncan Building, 6 West Derby Street , , ,","place":["Liverpool, United Kingdom, L7 8TX"]},{"name":"The MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) , ,","place":["Liverpool, United Kingdom, L7 8TX"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"issue":"1","key":"2026090200103185700_cit1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1146\/annurev.bioeng.2.1.83","article-title":"Injury\nand Repair of Ligaments and\nTendons","volume":"2","author":"Woo","year":"2000","journal-title":"Annu. 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Sports Med."},{"key":"2026090200103185700_cit6","doi-asserted-by":"publisher","first-page":"928301","DOI":"10.1155\/2015\/928301","article-title":"The Relationship between Anterior Cruciate Ligament\nInjury and Osteoarthritis of the Knee","volume":"2015","author":"Simon","year":"2015","journal-title":"Advances\nin Orthopedics"},{"issue":"9","key":"2026090200103185700_cit7","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1177\/0363546508316770","article-title":"Prevalence of Tibiofemoral\nOsteoarthritis\n15 Years After Nonoperative Treatment of Anterior Cruciate Ligament\nInjury: A Prospective Cohort Study","volume":"36","author":"Neuman","year":"2008","journal-title":"American\nJournal of Sports Medicine"},{"issue":"1","key":"2026090200103185700_cit8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2460\/javma.228.1.61","article-title":"Inheritance\nof rupture of the cranial\ncruciate ligament in Newfoundlands","volume":"228","author":"Wilke","year":"2006","journal-title":"J. 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