{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:16:45Z","timestamp":1761218205074,"version":"3.37.3"},"reference-count":94,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802344","81871445","U1632274"],"award-info":[{"award-number":["81802344","81871445","U1632274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2020,2,7]]},"DOI":"10.1021\/acs.jproteome.9b00635","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T16:53:51Z","timestamp":1578588831000},"page":"781-793","source":"Crossref","is-referenced-by-count":9,"title":["<sup>1<\/sup>H NMR-Based Metabolic Profiles Delineate the Anticancer Effect of Vitamin C and Oxaliplatin on Hepatocellular Carcinoma Cells"],"prefix":"10.1021","volume":"19","author":[{"given":"Caigui","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory for Plasma and Magnetic Resonance, Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-6548","authenticated-orcid":true,"given":"Jiyang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory for Plasma and Magnetic Resonance, Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiliang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21205, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kian-Kai","family":"Cheng","sequence":"additional","affiliation":[{"name":"Innovation Centre in Agritechnology, Universiti Teknologi Malaysia, Muar, Johor 84600, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, ZhongShan Hospital of Xiamen University, Xiamen, Fujian 361005, China"},{"name":"Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, ZhongShan Hospital of Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"You","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, ZhongShan Hospital of Xiamen University, Xiamen, Fujian 361005, China"},{"name":"Graduate College of Fujian Medical University, Fuzhou, Fujian 350004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory for Plasma and Magnetic Resonance, Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, ZhongShan Hospital of Xiamen University, Xiamen, Fujian 361005, China"},{"name":"Fujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, ZhongShan Hospital of Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1473-2224","authenticated-orcid":true,"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory for Plasma and Magnetic Resonance, Xiamen University, Xiamen, Fujian 361005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2020,1,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-016-0670-7"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-2-7"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.04.001"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.9.4538"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.10.3685"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1056\/nejm197909273011303"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198501173120301"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.8.3704"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-7-200404060-00010"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2012.713539"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-14-1707"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-09-1713"},{"key":"ref14\/cit14","first-page":"249","volume":"24","author":"Pollard H. B.","year":"2010","journal-title":"In Vivo"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007154"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/srep13896"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nature23876"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-017-0044-8"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2014-0509"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.03.007"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007154"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.7150\/thno.21745"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804226105"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.2174\/1568011023353958"},{"key":"ref25\/cit25","first-page":"1021","volume":"4","author":"Raymond E.","year":"1998","journal-title":"Clin. Cancer Res."},{"key":"ref26\/cit26","first-page":"227","volume":"1","author":"Raymond E.","year":"2002","journal-title":"Mol. Cancer Ther."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-008-0137-z"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.740"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-010-0242-7"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/ac051632c"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.7b00853"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl923"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0208-162"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ac060209g"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv380"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky310"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq329"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg382"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506390102"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702854104"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029794"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.3945\/an.110.000109"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2012.755263"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0074com"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-6-55"},{"key":"ref46\/cit46","first-page":"811","volume":"18","author":"Hong S.-W.","year":"2007","journal-title":"Oncol. Rep."},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1097\/01.cmr.0000232297.99160.9e"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-003-0407-6"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1080\/10715760500097906"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1023\/b:appt.0000018804.26026.1a"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.01.021"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.06.022"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.07.102"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1097\/cad.0b013e32834fd01f"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1002\/sca.4950200805"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1177\/002215540104900111"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-010-1418-6"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-09-1713"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6.3.11527"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.28.19792"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1172\/jci112068"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.2174\/187152011795677544"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.9.5294"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/S0021-9258(19)77928-9","volume":"263","author":"Hyslop P. A.","year":"1988","journal-title":"J. Biol. Chem."},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(03)00107-2"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m411662200"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.268.1.c227"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/nature11706"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1038\/364079a0"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1038\/19986"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05607.x"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa5004"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2015.09.005"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2270"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601623"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1172\/jci26390"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5662"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402233"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070306"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.026"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012485299"},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"7652","DOI":"10.1016\/S0021-9258(19)69010-1","volume":"256","author":"Schworer C. M.","year":"1981","journal-title":"J. Biol. Chem."},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1021\/cr068207j"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1021\/bi9703047"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10659"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.01.013"},{"key":"ref87\/cit87","first-page":"4043","volume":"45","author":"Micetich K. C.","year":"1985","journal-title":"Cancer Res"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1021\/cr020010d"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.4.837"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.16.1295"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6623"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2167"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(96)04245-0"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-267"}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jproteome.9b00635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T04:49:16Z","timestamp":1681706956000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jproteome.9b00635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,9]]},"references-count":94,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,7]]}},"alternative-id":["10.1021\/acs.jproteome.9b00635"],"URL":"https:\/\/doi.org\/10.1021\/acs.jproteome.9b00635","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"type":"print","value":"1535-3893"},{"type":"electronic","value":"1535-3907"}],"subject":[],"published":{"date-parts":[[2020,1,9]]}}}