{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T09:04:12Z","timestamp":1785143052538,"version":"3.55.0"},"reference-count":33,"publisher":"American Chemical Society (ACS)","issue":"23","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1207600"],"award-info":[{"award-number":["2022YFA1207600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22274157"],"award-info":[{"award-number":["22274157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A surface-enhanced Raman scattering (SERS) sensor built on a free-standing Au\/Cu-covalent organic framework (COF) membrane was developed for the noninvasive Helicobacter pylori detection by quantifying trace ammonia in exhaled breath. The porphyrin-based Cu-COF acts as a multifunctional sensing interface, using its porous structure and accessible porphyrin-Cu coordination sites to efficiently capture and preconcentrate ammonia vapor. The change of intensity of the characteristic SERS peak at the 391 cm\u20131 Raman peak (\u0394I391) shows a good linear relationship with ammonia concentration in the range of 0.5 to 3 ppm, with a limit of detection (LOD) down to 0.5 ppm. The sensor shows good stability and anti-interference ability toward common volatile organic compounds (VOCs) and inorganic gases in breath, allowing rapid detection without complex sample pretreatment. Notably, the introduction of Cu2+ significantly enhanced the crystallinity and structure ordering of the COF membrane, offering a new strategy for metal-ion-mediated structural regulation of 2D COF films. Preliminary clinical blind testing on exhaled breath samples yields a 70% diagnostic accuracy for H. pylori infection, validating the practical potential of this sensor. This work establishes a robust SERS platform for breath biomarker analysis and provides a promising route for noninvasive, real-time, and point-of-care diagnosis of H. pylori infection.<\/jats:p>","DOI":"10.1021\/acs.langmuir.6c02130","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:02:56Z","timestamp":1780574576000},"page":"17099-17108","source":"Crossref","is-referenced-by-count":0,"title":["A Au\/Cu-COF\nMembrane-Based SERS Sensor for Noninvasive\nDetection of\n                    <i>Helicobacter pylori<\/i>\n                    via\nExhaled Breath Ammonia"],"prefix":"10.1021","volume":"42","author":[{"given":"Wenjing","family":"Zhao","sequence":"first","affiliation":[{"name":"Lanzhou Jiaotong University , , ,","place":["Lanzhou, China, 730070"]},{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxi","family":"Li","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences , , ,","place":["Beijing, China, 100053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwan","family":"Su","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences , , ,","place":["Beijing, China, 100053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-4218","authenticated-orcid":true,"given":"Pengfei","family":"An","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Yao","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences , , ,","place":["Beijing, China, 100053"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-5787","authenticated-orcid":true,"given":"Shengbin","family":"Lei","sequence":"additional","affiliation":[{"name":"Lanzhou Jiaotong University , , ,","place":["Lanzhou, China, 730070"]},{"name":"Tianjin University , , ,","place":["Tianjin, China, 300072"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Tao","sequence":"additional","affiliation":[{"name":"Lanzhou Jiaotong University , , ,","place":["Lanzhou, China, 730070"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-9080","authenticated-orcid":true,"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"issue":"s1","key":"2026072621103095100_cit1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1365-2036.1998.00007.x","article-title":"Long-term Helicobacter Pylori Infection from Gastritis to Gastric\nCancer","volume":"12","author":"Asaka","year":"1998","journal-title":"Aliment. 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