{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:51:55Z","timestamp":1789487515265,"version":"build-2803163510"},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"36","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19030501200"],"award-info":[{"award-number":["19030501200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["24ZR1426800"],"award-info":[{"award-number":["24ZR1426800"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Henan Key Laboratory of Medical and Protective Products","doi-asserted-by":"publisher","award":["YDFH2024KF04"],"award-info":[{"award-number":["YDFH2024KF04"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Large-area wounds, such as burns, extensive trauma, and chronic nonhealing ulcers, present significant clinical challenges due to excessive exudation, high infection susceptibility, and the risk of secondary injury caused by frequent dressing removal for status inspection. These challenges necessitate advanced dressing materials that integrate efficient exudate management with real-time wound monitoring. In response, this study presents a fully biodegradable bilayer Janus electrospun dressing fabricated via layer-by-layer electrospinning. The dressing comprises a hydrophobic poly(3-hydroxybutyrate-co-3-hydroxyvalerate)\/polylactic acid (PHBV\/PLA) drainage layer for direct skin contact, coupled with a hydrophilic cellulose acetate\/epigallocatechin-3-gallate\/red cabbage anthocyanin (CA\/EGCG\/RCA) layer for exudate absorption. The resulting membranes were systematically characterized for morphology (SEM), wettability, mechanical properties, air permeability, and swelling behavior. Antibacterial assays demonstrated inhibition rates of 90% and 92% against Escherichia coli and Staphylococcus aureus, respectively. Furthermore, in vitro cytocompatibility assays confirmed superior biocompatibility, with L929 fibroblast viability exceeding 92%. Notably, the dressing functions as a biosensor for wound pH evaluation via a Python-based RGB algorithm that analyzes the exponential relationships between R\/B and R\/G color coordinates, providing critical guidance for clinical decision-making. Overall, the biodegradable PPCER Janus membrane offers a sustainable and intelligent strategy for large-area wound management by synergyizing antibacterial, antioxidant, and unidirectional moisture transport functionalities.<\/jats:p>","DOI":"10.1021\/acs.langmuir.6c03464","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:51:59Z","timestamp":1788418319000},"page":"26556-26567","source":"Crossref","is-referenced-by-count":0,"title":["Biodegradable\nJanus Electrospun Dressing with Unidirectional\nMoisture Transport and pH-Responsive Colorimetric Indication for Intelligent\nWound Management"],"prefix":"10.1021","volume":"42","author":[{"given":"Kainan","family":"Guo","sequence":"first","affiliation":[{"name":"Shanghai University of Engineering Science , , ,","place":["Shanghai, P. R. China, 201620"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai University of Engineering Science , , ,","place":["Shanghai, P. R. China, 201620"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyi","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai University of Engineering Science , , ,","place":["Shanghai, P. R. China, 201620"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai University of Engineering Science , , ,","place":["Shanghai, P. R. China, 201620"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyu","family":"Ding","sequence":"additional","affiliation":[{"name":"Shanghai University of Engineering Science , , ,","place":["Shanghai, P. R. China, 201620"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Xinjiang College of Science & Technology , , , ,","place":["Korla, Xinjiang, P. R. China, 841000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3258-7438","authenticated-orcid":true,"given":"Zhu","family":"Zhan","sequence":"additional","affiliation":[{"name":"Shanghai University of Engineering Science , , ,","place":["Shanghai, P. R. China, 201620"]},{"name":"Xinjiang College of Science & Technology , , , ,","place":["Korla, Xinjiang, P. R. China, 841000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-8018","authenticated-orcid":true,"given":"Binjie","family":"Xin","sequence":"additional","affiliation":[{"name":"Shanghai University of Engineering Science , , ,","place":["Shanghai, P. R. China, 201620"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1491-6074","authenticated-orcid":true,"given":"Kangkang","family":"Ou","sequence":"additional","affiliation":[{"name":"Shanghai University of Engineering Science , , ,","place":["Shanghai, P. R. China, 201620"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"issue":"11","key":"2026091510141069300_cit1","doi-asserted-by":"publisher","first-page":"5325","DOI":"10.1007\/s00289-025-05753-z","article-title":"Multifunctional polymeric wound dressings","volume":"82","author":"Soylu","year":"2025","journal-title":"Polym. Bull."},{"issue":"14","key":"2026091510141069300_cit2","doi-asserted-by":"publisher","first-page":"11674","DOI":"10.3390\/ijms241411674","article-title":"Biomedical Applications of the Biopolymer\nPoly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation\nand Scaffold Fabrication","volume":"24","author":"Rodriguez-Cendal","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"2026091510141069300_cit3","doi-asserted-by":"publisher","first-page":"5339","DOI":"10.1021\/acsbiomaterials.1c00757","article-title":"Development\nand Advantages of Biodegradable PHA Polymers\nBased on Electrospun PHBV Fibers for Tissue Engineering and Other\nBiomedical Applications","volume":"7","author":"Kaniuk","year":"2021","journal-title":"ACS Biomater. Sci.\nEng."},{"issue":"23","key":"2026091510141069300_cit4","doi-asserted-by":"publisher","first-page":"4271","DOI":"10.3390\/polym13234271","article-title":"Expanding Poly(lactic\nacid) (PLA) and Polyhydroxyalkanoates (PHAs) Applications: A Review\non Modifications and Effects","volume":"13","author":"Naser","year":"2021","journal-title":"Polymers"},{"key":"2026091510141069300_cit5","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.msec.2015.12.074","article-title":"Conductive\nPEDOT:PSS coated polylactide (PLA) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)\n(PHBV) electrospun membranes: Fabrication and characterization","volume":"61","author":"Chang","year":"2016","journal-title":"Mater. Sci. 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Pharm."},{"key":"2026091510141069300_cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2025.129035","article-title":"Smart colorimetric biodegradable PHBV\/PLA\/An nanofibrous\nmembrane for food freshness indicator","volume":"337","author":"Guo","year":"2025","journal-title":"Polymer"},{"issue":"4","key":"2026091510141069300_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.137142","article-title":"Development\nand characterization of antibacterial marine extract-infused cellulose\nacetate nanofibers as wound dressings for combatting multidrug-resistant\nwound infections","volume":"282","author":"Said","year":"2024","journal-title":"Int. J. Biol. 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Macromol."},{"issue":"3","key":"2026091510141069300_cit23","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1007\/s13197-019-03642-8","article-title":"Evaluation of antimicrobial\nand antioxidant activities for cellulose acetate films incorporated\nwith Rosemary and Aloe Vera essential oils","volume":"56","author":"El Fawal","year":"2019","journal-title":"J. Food Sci. Technol."},{"key":"2026091510141069300_cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2019.121610","article-title":"Electrospinning\nof uniform nanofibers\nof Polymers of Intrinsic Microporosity (PIM-1): The influence of solution\nconductivity and relative humidity","volume":"178","author":"Topuz","year":"2019","journal-title":"Polymer"},{"issue":"19","key":"2026091510141069300_cit25","doi-asserted-by":"publisher","first-page":"4036","DOI":"10.3390\/polym14194036","article-title":"Robust Electrospinning-Constructed\nCellulose Acetate@Anthocyanin Ultrafine Fibers: Synthesis, Characterization,\nand Controlled Release Properties","volume":"14","author":"Liu","year":"2022","journal-title":"Polymers"},{"issue":"2","key":"2026091510141069300_cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.145795","article-title":"Preparation\nof cinnamon essential oil-micelles\/blueberry anthocyanins-loaded\nPVA bifunctional electrospunning nanofibrous film for maintaining\nand monitoring shrimp freshness","volume":"493","author":"Zhang","year":"2025","journal-title":"Food Chem."},{"key":"2026091510141069300_cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.121794","article-title":"Cellulose acetate-based\nelectrospun nanofiber aerogel with excellent resilience and hydrophobicity\nfor efficient removal of drug residues and oil contaminations from\nwastewater","volume":"329","author":"Tian","year":"2024","journal-title":"Carbohydr. 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