{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T22:37:46Z","timestamp":1786747066312,"version":"build-2736575974"},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100002745","name":"Bayerische Forschungsstiftung","doi-asserted-by":"publisher","award":["AZ-1204-6"],"award-info":[{"award-number":["AZ-1204-6"]}],"id":[{"id":"10.13039\/501100002745","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002745","name":"Bayerische Forschungsstiftung","doi-asserted-by":"publisher","award":["DOK-179-17"],"award-info":[{"award-number":["DOK-179-17"]}],"id":[{"id":"10.13039\/501100002745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Controlling physicochemical properties of light-unresponsive drugs, by light, prima facie, a paradox approach. We expanded light control by ion pairing light-unresponsive salicylate or ibuprofen to photoswitchable azobenzene counterions, thereby reversibly controlling supramolecular structures, hence the drugs\u2019 physicochemical and kinetic properties. The resulting ion pairs photoliquefied into room-temperature ionic liquids under ultraviolet light. Aqueous solutions showed trans\u2013cis-dependent supramolecular structures under a light with wormlike aggregates decomposing into small micelles and vice versa. Light control allowed for permeation through membranes of cis-ibuprofen ion pairs within 12 h in contrast to the trans ion pairs requiring 72 h. In conclusion, azobenzene ion-pairing expands light control of physicochemical and kinetic properties to otherwise light-unresponsive drugs.<\/jats:p>","DOI":"10.1021\/acs.molpharmaceut.0c00720","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T11:17:26Z","timestamp":1603970246000},"page":"4704-4708","source":"Crossref","is-referenced-by-count":6,"title":["Controlling Supramolecular Structures of Drugs by\nLight"],"prefix":"10.1021","volume":"17","author":[{"given":"Johannes","family":"Wiest","sequence":"first","affiliation":[{"name":"University of Wu\u0308rzburg , , Am Hubland , ,","place":["Wu\u0308rzburg, Germany, 97074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Kehrein","sequence":"additional","affiliation":[{"name":"University of Wu\u0308rzburg , , Am Hubland , ,","place":["Wu\u0308rzburg, Germany, 97074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Saedtler","sequence":"additional","affiliation":[{"name":"University of Wu\u0308rzburg , , Am Hubland , ,","place":["Wu\u0308rzburg, Germany, 97074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schilling","sequence":"additional","affiliation":[{"name":"University of Wu\u0308rzburg , , Am Hubland , ,","place":["Wu\u0308rzburg, Germany, 97074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7982-7120","authenticated-orcid":true,"given":"Eleonora","family":"Cataldi","sequence":"additional","affiliation":[{"name":"University of Wu\u0308rzburg , , Am Hubland , ,","place":["Wu\u0308rzburg, Germany, 97074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4713-4068","authenticated-orcid":true,"given":"Christoph A.","family":"Sotriffer","sequence":"additional","affiliation":[{"name":"University of Wu\u0308rzburg , , Am Hubland , ,","place":["Wu\u0308rzburg, Germany, 97074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-7278","authenticated-orcid":true,"given":"Ulrike","family":"Holzgrabe","sequence":"additional","affiliation":[{"name":"University of Wu\u0308rzburg , , Am Hubland , ,","place":["Wu\u0308rzburg, Germany, 97074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Rudolf Virchow Center , , Josef-Schneider-Stra\u00dfe 2 , ,","place":["Wu\u0308rzburg, Germany, 97080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-4849","authenticated-orcid":true,"given":"Bettina","family":"Bo\u0308ttcher","sequence":"additional","affiliation":[{"name":"Rudolf Virchow Center , , Josef-Schneider-Stra\u00dfe 2 , ,","place":["Wu\u0308rzburg, Germany, 97080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Cronin-Golomb","sequence":"additional","affiliation":[{"name":"Tufts University , , Colby Street 4 , , ,","place":["Medford, Massachusetts, United States, 01867"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2903-7101","authenticated-orcid":true,"given":"Matthias","family":"Lehmann","sequence":"additional","affiliation":[{"name":"University of Wu\u0308rzburg , , Am Hubland , ,","place":["Wu\u0308rzburg, Germany, 97074"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Jung","sequence":"additional","affiliation":[{"name":"Goethe University , , Max-von-Laue-Stra\u00dfe 15 , ,","place":["Frankfurt a. 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