{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:50:38Z","timestamp":1790502638037,"version":"4.1.0"},"reference-count":33,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002489"],"award-info":[{"award-number":["UL1TR002489"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007703","name":"North Carolina State University","doi-asserted-by":"publisher","award":["Faculty Research and Professional Development Gran"],"award-info":[{"award-number":["Faculty Research and Professional Development Gran"]}],"id":[{"id":"10.13039\/100007703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21CA246414"],"award-info":[{"award-number":["R21CA246414"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008615","name":"Lineberger Comprehensive Cancer Center, University of North Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2021,10,4]]},"DOI":"10.1021\/acs.molpharmaceut.1c00535","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T14:57:32Z","timestamp":1631113052000},"page":"3920-3925","source":"Crossref","is-referenced-by-count":15,"title":["On-Demand Drug Release from Click-Refillable Drug Depots"],"prefix":"10.1021","volume":"18","author":[{"given":"Sandeep","family":"Palvai","sequence":"first","affiliation":[{"name":"Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Raleigh, North Carolina 27607, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Moody","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Raleigh, North Carolina 27607, United States"},{"name":"Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27607, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharda","family":"Pandit","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Raleigh, North Carolina 27607, United States"},{"name":"Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27607, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2963-3293","authenticated-orcid":true,"given":"Yevgeny","family":"Brudno","sequence":"additional","affiliation":[{"name":"Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Raleigh, North Carolina 27607, United States"},{"name":"Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina 27607, United States"},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2018.4661"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds293"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.18433\/J30C7D"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.06.170"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4009"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170404142840"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201603488"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1717705115"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S149887"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1417"},{"issue":"3","key":"ref11\/cit11","first-page":"189","volume":"5","author":"Pimm M. V.","year":"1988","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/ph13090245"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25204764"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2415"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/nrc903"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(95)00160-3"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/bc900315y"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs140"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00110"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0055-2"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1039\/c1lc20438f"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201507391"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201509673"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc30819c"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201203339"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/srep29018"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01508"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.05.005"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413027111"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201402527"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.05.033"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.0c00453"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b00589"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.1c00535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T09:10:43Z","timestamp":1682500243000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.1c00535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10,4]]}},"alternative-id":["10.1021\/acs.molpharmaceut.1c00535"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.1c00535","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,8]]}}}