{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:29:41Z","timestamp":1784827781034,"version":"3.55.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2022,7,4]]},"DOI":"10.1021\/acs.molpharmaceut.2c00161","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T10:53:07Z","timestamp":1651143187000},"page":"2367-2379","source":"Crossref","is-referenced-by-count":11,"title":["Overcoming Bioavailability Challenges of Dasabuvir and Enabling a Triple-Combination Direct-Acting Antiviral HCV Regimen through a Salt of Very Weak Acid for Oral Delivery"],"prefix":"10.1021","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0034-9424","authenticated-orcid":true,"given":"Shuang","family":"Chen","sequence":"first","affiliation":[{"name":"Research & Development, AbbVie, Inc., North Chicago, Illinois 60064, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Gao","sequence":"additional","affiliation":[{"name":"Research & Development, AbbVie, Inc., North Chicago, Illinois 60064, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Lou","sequence":"additional","affiliation":[{"name":"Research & Development, AbbVie, Inc., North Chicago, Illinois 60064, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodger F.","family":"Henry","sequence":"additional","affiliation":[{"name":"Research & Development, AbbVie, Inc., North Chicago, Illinois 60064, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DeAnne F.","family":"Stolarik","sequence":"additional","affiliation":[{"name":"Research & Development, AbbVie, Inc., North Chicago, Illinois 60064, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya P.","family":"Lipert","sequence":"additional","affiliation":[{"name":"Research & Development, AbbVie, Inc., North Chicago, Illinois 60064, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5972-3938","authenticated-orcid":true,"given":"Ahmad Y.","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Research & Development, AbbVie, Inc., North Chicago, Illinois 60064, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-2781","authenticated-orcid":true,"given":"Geoff G. Z.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research & Development, AbbVie, Inc., North Chicago, Illinois 60064, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.2174\/1574887109666140529222602"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1012493"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/jm401398x"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/7355_2018_42"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp150163"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(96)00423-1"},{"key":"ref7\/cit7","unstructured":"Flentge, C. A.; Hutchinson, D. K.; Betebenner, D. A.; Degoey, D. A.; Donner, P. L.; Kati, W. M.; Krueger, A. C.; Liu, D.; Liu, Y.; Longenecker, K. L.  Anti-infective Agents and Uses Thereof. U.S. Patent 8501238, August 6, 2013."},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01687"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016212804288"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c06837"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.1c01228"},{"key":"ref12\/cit12","unstructured":"AbbVie\nInternal Development Reports."},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600660104"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(94)90104-X"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.05.010"},{"key":"ref16\/cit16","first-page":"453","volume-title":"Encyclopaedia of Pharmaceutical Technology","volume":"13","author":"Bighley L.D.","year":"1996"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-005-2504-z"},{"key":"ref18\/cit18","volume-title":"Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice","author":"Qiu Y.","year":"2016","edition":"2"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.05.026"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jm701032y"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.11.028"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.08.040"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071719"},{"key":"ref24\/cit24","first-page":"135","volume-title":"Handbook of Pharmaceutical Salts: Properties, Selection, and Use","author":"Serajuddin A. T. M.","year":"2002"},{"key":"ref25\/cit25","first-page":"19","volume-title":"Handbook of Pharmaceutical Salts: Properties, Selection, and Use","author":"Pudipeddi M.","year":"2002"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/c2ce26055g"},{"key":"ref27\/cit27","volume-title":"Handbook of Pharmaceutical Salts; Properties, Selection, and Use","author":"Stahl P. H.","year":"2002"},{"key":"ref28\/cit28","unstructured":"DrugBank Online. https:\/\/go.drugbank.com\/drugs (accessed Dec. 17, 2021)."},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-011-9290-9"},{"key":"ref30\/cit30","unstructured":"Apex2, version 2008.5\u20130; Bruker AXS Inc.: Madison, WI, 2008."},{"key":"ref31\/cit31","unstructured":"Shelxtl, version 6.14; Bruker AXS Inc.: Madison, WI, 2003."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4128"},{"key":"ref33\/cit33","unstructured":"Center\nfor Drug Evaluation\nand Research, Food and Drug Administration. Waiver of In Vivo Bioavailability and Bioequivalence\nStudies for Immediate-Release Solid Oral Dosage Forms based on a Biopharmaceutics\nClassification System: Guidance for Industry. Dec 2017. https:\/\/www.gmp-compliance.org\/files\/guidemgr\/UCM070246.pdf."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20064"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/B978-0-12-802447-8.00017-0","volume-title":"Developing Solid Oral Dosage Forms","author":"Gao Y.","year":"2017"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600700103"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600700104"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600590512"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21650"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b01194"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2016.03.006"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.2c00161","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.2c00161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T08:23:15Z","timestamp":1682410995000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.2c00161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,28]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7,4]]}},"alternative-id":["10.1021\/acs.molpharmaceut.2c00161"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.2c00161","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,28]]}}}