{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:16:13Z","timestamp":1776870973332,"version":"3.51.2"},"reference-count":94,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2022,9,5]]},"DOI":"10.1021\/acs.molpharmaceut.2c00258","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T11:52:21Z","timestamp":1658749941000},"page":"3163-3177","source":"Crossref","is-referenced-by-count":6,"title":["Nanoparticle Fraught Liposomes: A Platform for Increased Antibiotic Selectivity in Multidrug Resistant Bacteria"],"prefix":"10.1021","volume":"19","author":[{"given":"Suzan","family":"Fangary","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, German University in Cairo (GUC), New Cairo 11835, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-4219","authenticated-orcid":true,"given":"Mohammad","family":"Abdel-Halim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, German University in Cairo (GUC), New Cairo 24681, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem K.","family":"Fathalla","sequence":"additional","affiliation":[{"name":"Pharmaceutical and Medicinal Chemistry, Saarland University, D-66123 Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghda","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, German University in Cairo (GUC), New Cairo 11835, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, German University in Cairo (GUC), New Cairo 11835, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5065-8634","authenticated-orcid":true,"given":"Matthias","family":"Engel","sequence":"additional","affiliation":[{"name":"Pharmaceutical and Medicinal Chemistry, Saarland University, D-66123 Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, German University in Cairo (GUC), New Cairo 11835, Egypt"},{"name":"Department of Pharmaceutics and Industrial Pharmacy-Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7048-7465","authenticated-orcid":true,"given":"Salma N.","family":"Tammam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, German University in Cairo (GUC), New Cairo 11835, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"ref1\/cit1","first-page":"277","volume":"40","author":"Ventola C. L.","year":"2015","journal-title":"PT"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2017.1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.2.374"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.9.3621-3624.2004"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.4.433"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.09.082"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2011.01.025"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S121956"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666171122104738"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2003.08.005"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90443-M"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2018.33"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16047195"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1186\/1477-3155-12-5"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm289"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S55807"},{"key":"ref17\/cit17","first-page":"265","volume":"29","author":"Markin V. S.","year":"1984","journal-title":"Gen. Physiol. Biophys."},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1076\/phbi.39.3.221.5934"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201404775"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b02767"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.2174\/1573412910666141114221935"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2020.01.003"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.05.033"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12060590"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.08.010"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0691.2003.00790.x"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047742"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/44.1.43"},{"key":"ref29\/cit29","volume-title":"Theory and practice of histological techniques","author":"Banchroft J. D.","year":"1996"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103759"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm357"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.21085"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2018.81217"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-013-4894-5"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b19921"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/nn201624c"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3109\/21691401.2014.913054"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.2174\/092986710790416290"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01547-05"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/9783527800681.ch6","volume-title":"Pharmaceutical Nanotechnology: Innovation and Production","author":"Tammam S. N.","year":"2016"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/ja0516460"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.07.082"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/c1jm00060h"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S30617"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2012.02.029"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmmm.2005.01.044"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1128\/9781555815929.ch18","volume-title":"Antimicrobial Agents","author":"Bryskier A.","year":"2014"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-70299-5","volume-title":"Nanotechnology Applied To Pharmaceutical Technology","author":"Rai M.","year":"2017"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00185"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S269340"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-012-0938-8"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2010.02.002"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.05.023"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA00074H"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.03.027"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1128\/jb.91.5.1863-1868.1966"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1917"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1727"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-83822012000300020"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1039\/c3tb21238f"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.12.3249-3256.2000"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.67.4.593-656.2003"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.1.65"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096288"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2015.00249"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.9.2458-2464.2000"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1021\/bm034130m"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.2000.01078.x"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.12691\/ajidm-2-1-2"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20058856"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/16\/10\/059"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1039\/b706615e"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2009.12.004"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.09.020"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1039\/c0jm00817f"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S213229"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2015.2017"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.12.019"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9562-y"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(01)00218-4"},{"key":"ref82\/cit82","doi-asserted-by":"crossref","DOI":"10.1039\/9781849735292","volume-title":"Nanostructured Biomaterials for Overcoming Biological Barriers: Drug Discovery","author":"Alonso M. J.","year":"2012"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.22038\/ijbms.2018.31499.7643"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203501"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101765"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2019-0040"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(01)01267-3"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2011.05.014"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1998.00560.x"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2014.04.018"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.08.013"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-018-1256-0"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1211\/0022357021701"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.12.048"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.2c00258","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.2c00258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T14:45:51Z","timestamp":1682520351000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.2c00258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,25]]},"references-count":94,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,5]]}},"alternative-id":["10.1021\/acs.molpharmaceut.2c00258"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.2c00258","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,25]]}}}