{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:56:27Z","timestamp":1769270187358,"version":"3.49.0"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2022,9,5]]},"DOI":"10.1021\/acs.molpharmaceut.2c00449","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T16:51:56Z","timestamp":1659459116000},"page":"3267-3278","source":"Crossref","is-referenced-by-count":14,"title":["Molecular Mechanism of Antimicrobial Excipient-Induced Aggregation in Parenteral Formulations of Peptide Therapeutics"],"prefix":"10.1021","volume":"19","author":[{"given":"Mingyue","family":"Li","sequence":"first","affiliation":[{"name":"Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley T.","family":"Falk","sequence":"additional","affiliation":[{"name":"Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyu","family":"Lu","sequence":"additional","affiliation":[{"name":"Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Schroder","sequence":"additional","affiliation":[{"name":"Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-6605","authenticated-orcid":true,"given":"Mark","family":"Mccoy","sequence":"additional","affiliation":[{"name":"Computational and Structural Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel H.","family":"Yin","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian E.","family":"Gindy","sequence":"additional","affiliation":[{"name":"Small Molecule Science and Technology, Merck & Co., Inc., Rahway, New Jersey 07065, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6464-0758","authenticated-orcid":true,"given":"Suzanne M.","family":"D\u2019Addio","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5063-3218","authenticated-orcid":true,"given":"Yongchao","family":"Su","sequence":"additional","affiliation":[{"name":"Analytical Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-00135-8"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27031075"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.4155\/tde.14.5"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20976"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1695"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1177\/193229681000400609"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b00106"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-019-0238-6"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2017.0030"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.06.044"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1208\/ps050208"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012190120061"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22778"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22426"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20219"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-015-1697-z"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23362"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(96)04577-2"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011902215383"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24105"},{"key":"ref21\/cit21","first-page":"1153","volume":"350","author":"Strassmair H.","year":"1969","journal-title":"Hoppe Seylers Z. Physiol. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22601"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(03)74962-5"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/bi980807s"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9872.1000245"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.1c00803"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2020.12.030"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2020.09.027"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201800631"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/jps.10589"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20619"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/bi052132g"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2008.06.022"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2011.06.067"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(97)01474-9"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnmrs.2013.02.001"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(76)90122-0"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.94.630"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b00464"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC00741K"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.02.025"},{"key":"ref42\/cit42","first-page":"149","volume":"4","author":"Brange J.","year":"1992","journal-title":"Acta. Pharm. Nord."},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00292"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42531-8"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00174"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/nsb798"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060614-034206"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.06.048"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/bi501260r"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-012-1421-9"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/ja103658h"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/pro.600"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/ja4126092"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06761-6"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.1c00915"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2020.11.017"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-022-03318-7"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.02.007"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.116152"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.2c00449","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.2c00449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T14:46:16Z","timestamp":1682520376000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.2c00449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,2]]},"references-count":59,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,5]]}},"alternative-id":["10.1021\/acs.molpharmaceut.2c00449"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.2c00449","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,2]]}}}