{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:04:55Z","timestamp":1779933895033,"version":"3.53.1"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100014810","name":"Fondazione di Sardegna","doi-asserted-by":"publisher","award":["CUP F73C22001170007"],"award-info":[{"award-number":["CUP F73C22001170007"]}],"id":[{"id":"10.13039\/100014810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013003","name":"University of Cagliari","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2025,1,6]]},"DOI":"10.1021\/acs.molpharmaceut.4c01095","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T07:24:14Z","timestamp":1733901854000},"page":"498-508","source":"Crossref","is-referenced-by-count":5,"title":["Design and Bottom-up Production of an Aerosolizable Cannabidiol Nanosuspension"],"prefix":"10.1021","volume":"22","author":[{"given":"Luca","family":"Casula","sequence":"first","affiliation":[{"name":"Department of Life and Environmental Sciences","place":["Monserrato, Italy"]},{"name":"University of Cagliari","place":["Monserrato, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7214-9045","authenticated-orcid":true,"given":"Michele","family":"Schlich","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences","place":["Monserrato, Italy"]},{"name":"University of Cagliari","place":["Monserrato, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Cardia","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences","place":["Monserrato, Italy"]},{"name":"University of Cagliari","place":["Monserrato, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1070-1295","authenticated-orcid":true,"given":"Eleonora","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences","place":["Monserrato, Italy"]},{"name":"University of Cagliari","place":["Monserrato, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Marceddu","sequence":"additional","affiliation":[{"name":"Istituto di Scienze delle Produzioni Alimentari (ISPA)\u2500CNR","place":["Sez. di Sassari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Pireddu","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences","place":["Monserrato, Italy"]},{"name":"University of Cagliari","place":["Monserrato, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Valenti","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences","place":["Monserrato, Italy"]},{"name":"University of Cagliari","place":["Monserrato, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Sinico","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences","place":["Monserrato, Italy"]},{"name":"University of Cagliari","place":["Monserrato, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9858-5273","authenticated-orcid":true,"given":"Francesco","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences","place":["Monserrato, Italy"]},{"name":"University of Cagliari","place":["Monserrato, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-566X","authenticated-orcid":true,"given":"Elena","family":"Pini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, (DISFARM)","place":["Milano, Italy"]},{"name":"University of Milan","place":["Milano, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13710"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9010021"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01530-y"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1089\/can.2016.0034"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s40429-020-00326-8"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93760"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0650"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17030325"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.15"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-020-02054-6"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-69186-8_17"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-69186-8_15"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-69186-8_14"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-25.1.75"},{"key":"ref15\/cit15","unstructured":"Greenwich Biosciences. EPIDIOLEX (Cannabidiol) Oral Solution. Full Prescribing\nInformation\n(Package Insert) 2024 https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2024\/210365s021lbl.pdf."},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27186070"},{"key":"ref17\/cit17","unstructured":"World Health\nOrganization (WHO). CANNABIDIOL\n(CBD) Critical Review Report. June 4-7. 2018."},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01365"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200140904"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1300\/J175v03n03_03"},{"issue":"3","key":"ref21\/cit21","first-page":"367","volume":"50","author":"Rau J. L.","year":"2005","journal-title":"Respir. Care"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.09.020"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103805"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124370"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124235"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(91)90053-G"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.995087"},{"issue":"10","key":"ref28\/cit28","first-page":"1313","volume":"50","author":"Geller D. E.","year":"2005","journal-title":"Respir. Care"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22665"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120293"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.1616"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014276917363"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15092308"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(97)00311-6"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122836"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.105979"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-014-0211-y"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.01.019"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118839"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2012.09.018"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00098"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21380"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.17222\/mit.2018.253"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-022-02239-3"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S452207"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.2c00041"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122079"},{"issue":"1","key":"ref48\/cit48","first-page":"21","volume":"2008","author":"Berg E.","year":"2008","journal-title":"Pharmeuropa Sci. Notes"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1089\/jam.2004.17.335"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13081300"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122325"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/9781118397145.ch6"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.09.021"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666151027152350"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-017-0446-8"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.12.009"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2020-0306TR"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.06.017"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2021.116070"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1186\/s40543-015-0073-2"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.10.007"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007516718048"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2021.07.012"},{"issue":"1","key":"ref64\/cit64","first-page":"16","volume":"15","author":"Kollamaram G.","year":"2024","journal-title":"J. Excipients Food Chem."},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S265167"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S122726"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(95)00033-F"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102662"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13040503"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/s11671-008-9234-1"},{"issue":"3","key":"ref71\/cit71","first-page":"785","volume":"13","author":"Ali H. S. M.","year":"2014","journal-title":"Iran. J. Pharm. Res."},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.08.007"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.4c01095","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.4c01095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T10:56:14Z","timestamp":1740480974000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.4c01095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,6]]}},"alternative-id":["10.1021\/acs.molpharmaceut.4c01095"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.4c01095","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,11]]}}}