{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:13:53Z","timestamp":1789841633910,"version":"4.0.1"},"reference-count":61,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2025,10,6]]},"DOI":"10.1021\/acs.molpharmaceut.5c00611","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T14:57:16Z","timestamp":1758293836000},"page":"5959-5974","source":"Crossref","is-referenced-by-count":3,"title":["Tween 80-Modified Chitosan Nanoparticles via Ionotropic Gelation for Enhanced Brain Delivery of Chrysin and Improved Anxiolytic Efficacy in Preclinical Models"],"prefix":"10.1021","volume":"22","author":[{"given":"Payal","family":"Dey","sequence":"first","affiliation":[{"name":"Centre of Pharmaceutics","place":["Noida, India"]},{"name":"Amity Institute of Pharmacy, Amity University Uttar Pradesh","place":["Noida, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1945-4808","authenticated-orcid":true,"given":"Somesh","family":"Narayan","sequence":"additional","affiliation":[{"name":"Centre of Pharmaceutics","place":["Noida, India"]},{"name":"Amity Institute of Pharmacy, Amity University Uttar Pradesh","place":["Noida, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0790-784X","authenticated-orcid":true,"given":"Kalpana","family":"Nagpal","sequence":"additional","affiliation":[{"name":"Centre of Pharmaceutics","place":["Noida, India"]},{"name":"Amity Institute of Pharmacy, Amity University Uttar Pradesh","place":["Noida, India"]},{"name":"Centre of Pharmaceutical Regulatory Affairs, Amity Institute of Pharmacy","place":["Uttar Pradesh, India"]},{"name":"Amity University Noida","place":["Uttar Pradesh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.21276\/ijlssr.2018.4.2.17"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-64017-4"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.132129"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(79)90484-3"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2017.19.2\/bbandelow"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s10812-022-01338-0"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.09.111"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.12988\/ces.2015.511304"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12111013"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2024.104997"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3390\/ma14123197"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(01)00095-1"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2024.112533"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3662-6_8"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2012.07.009"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2013.04.024"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2013.779330"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c12-00732"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.2174\/1871527321666220602111935"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2005.00389.x"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2015.10.003"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16081043"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2024.112266"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113551"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1186\/s43045-023-00315-3"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2016.09.014"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-020-00230-3"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7172-5_4"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.516"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.035162"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119927"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2025.2514714"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2003.077"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.5958\/2231-5691.2020.00051.9"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10020057"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26216456"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2013-1155"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.58.1423"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.595584"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1080\/10611860310001615956"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75253-9"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01798-2"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29061411"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2020"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/mps6040063"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113551"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.9734\/jsrr\/2021\/v27i930437"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23064-4"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/nu13062038"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1088\/1757-899X\/311\/1\/012024"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.3791\/104"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.69234"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-016-1391-z"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.105026"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1377315"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2024.112266"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2009.1067"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000016249.52831.a5"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2003.077"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.3390\/mps6040063"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.5c00611","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.5c00611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T08:11:40Z","timestamp":1759738300000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.5c00611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,19]]},"references-count":61,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,6]]}},"alternative-id":["10.1021\/acs.molpharmaceut.5c00611"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.5c00611","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,19]]}}}