{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:55:39Z","timestamp":1793044539904,"version":"4.5.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2022\/003774"],"award-info":[{"award-number":["CRG\/2022\/003774"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2026,1,5]]},"DOI":"10.1021\/acs.molpharmaceut.5c01161","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:44:35Z","timestamp":1764171875000},"page":"373-385","source":"Crossref","is-referenced-by-count":5,"title":["Fabrication and Evaluation of PLGA Microsphere-Loaded Hydrogels as Potential Intraocular Lens for Sustained Release of Timolol Maleate"],"prefix":"10.1021","volume":"23","author":[{"given":"Shahid Iqbal","family":"Mir","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering","place":["Roorkee, India"]},{"name":"Indian Institute of Technology Roorkee","place":["Roorkee, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yethmini","family":"Senadheera","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering","place":["Roorkee, India"]},{"name":"Indian Institute of Technology Roorkee","place":["Roorkee, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3499-7307","authenticated-orcid":true,"given":"Debrupa","family":"Lahiri","sequence":"additional","affiliation":[{"name":"Biomaterials and Multiscale Mechanics Lab, Department of Metallurgical and Materials Engineering","place":["Roorkee, India"]},{"name":"Indian Institute of Technology Roorkee","place":["Roorkee, India"]},{"name":"Centre for Nanotechnology","place":["Roorkee, India"]},{"name":"Indian Institute of Technology Roorkee","place":["Roorkee, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9844-2875","authenticated-orcid":true,"given":"Prateek K.","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering","place":["Roorkee, India"]},{"name":"Indian Institute of Technology Roorkee","place":["Roorkee, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","unstructured":"WHO.\n                      World Report on Vision\n                      ; World\nHealth Organisation, 2019; Vol. 214; p 180.","DOI":"10.1016\/j.vaccine.2018.04.022"},{"key":"ref2\/cit2","unstructured":"Understanding\nthe Leading Causes of Blindness|Ophthalmology &\nVisual Sciences. https:\/\/ophthalmology.wustl.edu\/understanding-the-leading-causes-of-blindness\/ (accessed April 22, 2025)."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30293-0"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100852"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30488-5"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14024"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-016-0332-7"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S118409"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9010041"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.3.2.275"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000000529"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.05.035"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2020.1712175"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.110885"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/ie0507934"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73753-5"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1007\/s00170-018-2274-5"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3390\/polym15061590"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3390\/mi10040233"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-981-10-2627-0_14","volume-title":"Pediatric Lens Diseases","author":"Lin H.","year":"2017"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1108\/rpj-10-2017-0205"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1177\/0309364615579317"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.4028\/www.scientific.net\/MSF.919.199"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-019-04312-3"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2022.01.004"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122094"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3390\/mi14020464"},{"key":"ref28\/cit28","unstructured":"DURYSTA (bimatoprost intracameral implant)|Patient\nWebsite. https:\/\/www.durysta.com\/ (accessed April 12, 2025)."},{"key":"ref29\/cit29","volume-title":"HIGHLIGHTS OF PRESCRIBING INFORMATION These Highlights Do Not Include all the Information Needed to Use DURYSTA Safely and Effectively. See Full Prescribing Information for DURYSTA. DURYSTA (Bimatoprost Implant), for Intracameral Administration","author":"CDER FDA","year":"2008"},{"key":"ref30\/cit30","unstructured":"iDose TR|Glaukos. https:\/\/www.glaukos.com\/glaucoma\/products\/idose-tr\/ (accessed April 12, 2025)."},{"key":"ref31\/cit31","unstructured":"U.S. Patent for\nIntraocular drug delivery platform Patent (Patent\n# 12,161,548 issued December 10, 2024)-Justia Patents Search. https:\/\/patents.justia.com\/patent\/12161548 (accessed April 12, 2025)."},{"key":"ref32\/cit32","unstructured":"Intraocular Drug\nDelivery That Lasts|Spyglass Pharma. https:\/\/www.spyglasspharma.com\/ (accessed April 12, 2025)."},{"key":"ref33\/cit33","unstructured":"SpyGlass Pharma\nunveils 1-year data of drug delivery platform implanted\nduring routine cataract surgery in patients diagnosed with glaucoma. https:\/\/www.ophthalmologytimes.com\/view\/spyglass-pharma-unveils-1-year-data-of-drug-delivery-platform-implanted-during-routine-cataract-surgery-in-patients-diagnosed-with-glaucoma?utm_source=chatgpt.com (accessed April 12, 2025)."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.09.029"},{"key":"ref35\/cit35","unstructured":"Data on IOL-based Delivery of Bimatoprost Presented\nat ASCRS|Glaucoma\nPhysician. https:\/\/glaucomaphysician.net\/issues\/2024\/june\/data-on-iol-based-delivery-of-bimatoprost-presented-at-ascrs\/?utm_source=chatgpt.com (accessed April 12, 2025)."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S445005"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2024.09.001"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1977.04450040067008"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","unstructured":"Cosentino, M.; Storelli, E.; Luini, A.; LM\nLegnaro, M.; Rasini, E.; Ferrari, M.; Marino, F.\n                      SOLUTION- 02 - Phosphate Buffered Saline (PBS) V2\n                      . 2020, 10.17504\/PROTOCOLS.IO.BIAHKAB6.","DOI":"10.17504\/PROTOCOLS.IO.BIAHKAB6"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1080\/02652040802095250"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/polym16182562"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2020.10.03"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00115-0"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.3390\/polym3031377"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.18240\/IJO.2021.03.04"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","unstructured":"Ehrmann, K.; Kim, E.; Parel, J.M. Mechanical Properties of Intra-Ocular Lenses;\n                      Proceedings Volume 6844, Ophthalmic Technologies XVIII\n                      , 2008; Vol. 6844, p 68440O.","DOI":"10.1117\/12.787107"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/bf00920063"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.02.014"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbab060"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.5c01161","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.5c01161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:38:04Z","timestamp":1768563484000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.5c01161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,5]]}},"alternative-id":["10.1021\/acs.molpharmaceut.5c01161"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.5c01161","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]}}}