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Traditional Chinese Medicine-derived bioactives provide structurally diverse small-molecule payloads with promising antibiofilm potential, but their therapeutic utility is often constrained by poor aqueous solubility, chemical instability, rapid clearance, and insufficient local retention at the infected sites. This Review surveys recent advances in drug delivery-enabled antibiofilm therapeutics based on TCM-derived bioactives, with emphasis on how delivery design addresses distinct biofilm-associated barriers. Representative payload liabilities are first discussed to clarify why formulation design is central to improving performance. Major delivery platforms, including nanoparticles, hydrogels, and microneedle-assisted systems, are then compared by using shared pharmaceutics criteria such as loading strategy, release behavior, penetration, retention, and model relevance. In addition, photodynamic, photothermal, and sonodynamic approaches are examined as combination strategies that can augment delivery-enabled biofilm control. Rather than cataloging natural products or delivery systems, this Review focuses on the relationship among biofilm barriers, payload properties, delivery design, and preclinical evaluation. Current challenges related to model relevance, quality consistency, safety, manufacturability, and further development are also discussed. Overall, this Review aims to provide a practical framework for the rational design of antibiofilm therapeutics based on TCM-derived bioactives.<\/jats:p>","DOI":"10.1021\/acs.molpharmaceut.6c00514","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:00:27Z","timestamp":1784005227000},"page":"3973-4002","source":"Crossref","is-referenced-by-count":1,"title":["Drug Delivery-Enabled\nAntibiofilm Therapeutics from\nTraditional Chinese Medicine-Derived Bioactives: Recent Advances and\nFuture Perspectives"],"prefix":"10.1021","volume":"23","author":[{"given":"Ying","family":"Chen","sequence":"first","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences, Central South University , ,","place":["Changsha, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duoyang","family":"Fan","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences, Central South University , ,","place":["Changsha, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohan","family":"Li","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences, Central South University , ,","place":["Changsha, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences, Central South University , ,","place":["Changsha, China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences , , ,","place":["Beijing, China, 100700"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8314-9174","authenticated-orcid":true,"given":"Wenbin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences, Central South University , ,","place":["Changsha, China, 410013"]},{"name":"Central South University , , ,","place":["Changsha, P. R. China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-1945","authenticated-orcid":true,"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Sciences, Central South University , ,","place":["Changsha, China, 410013"]},{"name":"Central South University , , ,","place":["Changsha, P. R. China, 410013"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"2026080309080565600_cit1","doi-asserted-by":"publisher","first-page":"100954","DOI":"10.1016\/j.drup.2023.100954","article-title":"Antimicrobial peptides\nfor combating drug-resistant bacterial infections","volume":"68","author":"Xuan","year":"2023","journal-title":"Drug Resist. 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