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Antimicrobial photodynamic therapy (aPDT), as an alternative strategy, produces reactive oxygen species (ROS) under light activation and kills drug-resistant bacteria through oxidative damage. Nevertheless, conventional photosensitizers (PSs) are limited by aggregation-caused quenching, inadequate bacterial selectivity, and off-target cytotoxicity. Quaternary ammonium salts (QASs) can preferentially accumulate on bacterial membranes through electrostatic interactions and disrupt the bacterial membranes. The quaternary ammonium PS PK4, reported here has a triphenylamine unit that enhances ROS production. Under white light irradiation, PK4 produces abundant ROS that oxidatively damage bacterial membranes, while exhibiting high photostability and minimal dark toxicity. In an MRSA-infected wound model, PK4-mediated phototherapy can reduce inflammation, accelerate wound healing, and enhance collagen deposition without systemic toxicity, providing a promising aPDT strategy for combating drug-resistant bacterial infections.<\/jats:p>","DOI":"10.1021\/acs.molpharmaceut.6c00673","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T07:53:55Z","timestamp":1784706835000},"page":"4322-4332","source":"Crossref","is-referenced-by-count":0,"title":["Quaternary\nAmmonium-Functionalized Membrane-Anchored\nPhotosensitizer against Multidrug-Resistant Bacterial Infections"],"prefix":"10.1021","volume":"23","author":[{"given":"Yan","family":"Zeng","sequence":"first","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, China, 211198"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Tang","sequence":"additional","affiliation":[{"name":"China Pharmaceutical University , , ,","place":["Nanjing, P. 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