{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:25:49Z","timestamp":1792729549103,"version":"4.5.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"2","funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG054473"],"award-info":[{"award-number":["R01 AG054473"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA038000"],"award-info":[{"award-number":["DA038000"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2018,2,5]]},"DOI":"10.1021\/acs.molpharmaceut.7b00936","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T03:20:28Z","timestamp":1515036028000},"page":"695-702","source":"Crossref","is-referenced-by-count":15,"title":["Metal Protein-Attenuating Compound for PET Neuroimaging: Synthesis and Preclinical Evaluation of [<sup>11<\/sup>C]PBT2"],"prefix":"10.1021","volume":"15","author":[{"given":"Hema S.","family":"Krishnan","sequence":"first","affiliation":[{"name":"Division\rof Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts 02114, United States"},{"name":"Department\rof Radiology, Harvard Medical School, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim","family":"Bernard-Gauthier","sequence":"additional","affiliation":[{"name":"Division\rof Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts 02114, United States"},{"name":"Department\rof Radiology, Harvard Medical School, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Placzek","sequence":"additional","affiliation":[{"name":"Department\rof Radiology, Harvard Medical School, Boston, Massachusetts 02115, United States"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Dahl","sequence":"additional","affiliation":[{"name":"Division\rof Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts 02114, United States"},{"name":"Department\rof Radiology, Harvard Medical School, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Narayanaswami","sequence":"additional","affiliation":[{"name":"Division\rof Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts 02114, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijahu","family":"Livni","sequence":"additional","affiliation":[{"name":"Division\rof Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts 02114, United States"},{"name":"Department\rof Radiology, Harvard Medical School, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division\rof Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts 02114, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department\rof Radiology, Harvard Medical School, Boston, Massachusetts 02115, United States"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Collier","sequence":"additional","affiliation":[{"name":"Division\rof Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts 02114, United States"},{"name":"Department\rof Radiology, Harvard Medical School, Boston, Massachusetts 02115, United States"},{"name":"Research\rand Development, Advion Inc., Ithaca, New York 14850, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongzhao","family":"Ran","sequence":"additional","affiliation":[{"name":"Department\rof Radiology, Harvard Medical School, Boston, Massachusetts 02115, United States"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9394-7708","authenticated-orcid":true,"given":"Jacob M.","family":"Hooker","sequence":"additional","affiliation":[{"name":"Department\rof Radiology, Harvard Medical School, Boston, Massachusetts 02115, United States"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-6315","authenticated-orcid":true,"given":"Steven H.","family":"Liang","sequence":"additional","affiliation":[{"name":"Division\rof Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts 02114, United States"},{"name":"Department\rof Radiology, Harvard Medical School, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2087-5125","authenticated-orcid":true,"given":"Neil","family":"Vasdev","sequence":"additional","affiliation":[{"name":"Division\rof Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts 02114, United States"},{"name":"Department\rof Radiology, Harvard Medical School, Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,1,22]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/475S2a"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200802808"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.08.014"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1039\/b807980n"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.446"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1039\/B813398K"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/cr040410w"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2008.05.001"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.10.558"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2732"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0730423100"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407881102"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1042\/BST0380552"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/ar300074t"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2010.00231.x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00317-8"},{"key":"ref17\/cit17","unstructured":"Clioquinol.http:\/\/www.alzforum.org\/therapeutics\/clioquinol."},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-871241"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.942"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2006.00196.x"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1039\/c2md20075a"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc45166f"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5b00055"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006091107"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/ml500413d"},{"key":"ref26\/cit26","unstructured":"Barnham, K. J.; Gautier, E. C. L.; Kok, G. B.; Krippner, G.Preparation of 8-hydroxyquinolines for treatment of neurological conditions. WO2004007461A1, 2004."},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2008-15208"},{"key":"ref28\/cit28","unstructured":"Barnham, K. J.; Gautier, E. C. L.; Kok, G. B.; Krippner, G.Preparation of 8-hydroxyquinolines for treatment of neurological conditions. US20080161353A1, 2008."},{"issue":"2","key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3233\/JHD-120029","volume":"1","author":"Cherny R. A.","year":"2012","journal-title":"J. Huntingtons Dis"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000334"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017669"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1390"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70167-4"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07402.x"},{"key":"ref35\/cit35","unstructured":"PBT2 Takes a Dive in Phase 2 Alzheimer\u2019s Trial.http:\/\/www.alzforum.org\/news\/research-news\/pbt2-takes-dive-phase-2-alzheimers-trial."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.069088"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.9"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-014-0022-9"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.063305"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.11.005"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/jm030026b"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283168e1a"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp062"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70262-5"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5b00281"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201502824"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201601120"},{"key":"ref48\/cit48","unstructured":"PBT 2.http:\/\/adisinsight.springer.com\/drugs\/800019374."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308535110"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.7b00936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T23:10:16Z","timestamp":1682464216000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.7b00936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2,5]]}},"alternative-id":["10.1021\/acs.molpharmaceut.7b00936"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.7b00936","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,22]]}}}