{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:52:51Z","timestamp":1791499971657,"version":"4.3.4"},"reference-count":27,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2018,3,5]]},"DOI":"10.1021\/acs.molpharmaceut.7b00973","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T20:15:27Z","timestamp":1516133727000},"page":"831-839","source":"Crossref","is-referenced-by-count":17,"title":["Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability"],"prefix":"10.1021","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-0903","authenticated-orcid":true,"given":"Pankaj R.","family":"Daga","sequence":"first","affiliation":[{"name":"Novartis Institute of Biomedical Research, Emeryville, California 94608, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Bolger","sequence":"additional","affiliation":[{"name":"Simulations Plus, Inc., 42505 10th Street West, Lancaster, California 93534, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.","family":"Haworth","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Clark","sequence":"additional","affiliation":[{"name":"Simulations Plus, Inc., 42505 10th Street West, Lancaster, California 93534, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7040-5108","authenticated-orcid":true,"given":"Eric J.","family":"Martin","sequence":"additional","affiliation":[{"name":"Novartis Institute of Biomedical Research, Emeryville, California 94608, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,1,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01875"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-364-6_20"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00129-0"},{"key":"ref4\/cit4","first-page":"420","volume-title":"Drug Bioavailability","author":"Bolger M. B.","year":"2004"},{"key":"ref5\/cit5","first-page":"453","volume-title":"Drug Bioavailability","author":"Bolger M. B.","year":"2009"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/026119290903700507","volume":"37","author":"Thomas S.","year":"2009","journal-title":"ALTA, Altern. Lab. Anim."},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2014.934671"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.2174\/138920010791514306"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00179-X"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00972"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9372-3"},{"key":"ref12\/cit12","first-page":"221","volume-title":"Hit and Lead Profiling","author":"Berry P.","year":"2010"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2012.06.013"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v018.i02"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-21706-2","volume-title":"Modern Applied Statistics with S","author":"Venables W. N.","year":"2002"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0021-9258(18)85644-7","volume":"55","author":"Levene P. A.","year":"1923","journal-title":"J. Biol. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ci049714+"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600831103"},{"key":"ref19\/cit19","first-page":"46","volume":"6","author":"Garson G. D.","year":"1991","journal-title":"AI Expert"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/0954-1810(94)00011-S"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1175\/1520-0442(1994)007<0681:AEWTFA>2.0.CO;2"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1063\/1.1680571"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-9473(97)00043-1"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4754(00)00270-6"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1991.10484804"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/ie900139x"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/jp108017t"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.7b00973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:21:24Z","timestamp":1682641284000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.7b00973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,16]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3,5]]}},"alternative-id":["10.1021\/acs.molpharmaceut.7b00973"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.7b00973","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,16]]}}}