{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T00:05:51Z","timestamp":1794441951521,"version":"4.9.1"},"reference-count":75,"publisher":"American Chemical Society (ACS)","issue":"11","funder":[{"DOI":"10.13039\/501100000836","name":"University of Liverpool","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2018,11,5]]},"DOI":"10.1021\/acs.molpharmaceut.8b00482","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T17:21:06Z","timestamp":1539364866000},"page":"4835-4842","source":"Crossref","is-referenced-by-count":64,"title":["Inhibitory Effects of Commonly Used Excipients on P-Glycoprotein in Vitro"],"prefix":"10.1021","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3495-2563","authenticated-orcid":true,"given":"Rohan","family":"Gurjar","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Y. S.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Curley","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Sharp","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Chiong","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Rannard","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Siccardi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GF, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2018,10,12]]},"reference":[{"key":"ref1\/cit1","unstructured":"The International Pharmaceutical Excipients Council.\n                      The IPEC Excipient Composition Guide\n                      , 2009."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2014.05.005"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2014.09.004"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-016-0558-3"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2007.08.021"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/mp3001815"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/mp400175n"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0170-2"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2009.05.001"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-008-9635-y"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12362"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(03)00079-X"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1177\/109158180302200507"},{"issue":"4","key":"ref14\/cit14","first-page":"277","volume":"19","author":"Lim T. Y.","year":"2014","journal-title":"J. Pediatr Pharmacol Ther."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.21.7735"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342010-00003"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nrc706"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.113.056176"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2011.572905"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.109156"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-016-9928-8"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2004.03.001"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2005.04.003"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(96)80007-5"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016140429238"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/jin2.21"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13184"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201300280"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(93)90011-U"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.200"},{"key":"ref31\/cit31","unstructured":"U.S. Food and Drug Administration, Center for Drug Evaluation and Research;\n                      Guidance for industry: Drug interaction studies\u2014study design, data analysis, implications for dosing, and labeling recommendations\n                      ; available at http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/ucm292362.pdf."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.005660"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(02)00055-6"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92260-2"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.11.005"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.02.006"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2016.12.003"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/mp060121r"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00171-X"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20017"},{"key":"ref41\/cit41","unstructured":"Bristol-Myers Squibb.\n                      Taxol (paclitaxel) Injection\n                      ; Reference ID: 2939751; 2011; https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2011\/020262s049lbl.pdf."},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.7.1263"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2015.1054396"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.11.024"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2009.07.010"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.09.010"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1007\/BF02976689"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(03)00163-9"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.745"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2747"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/bm301661w"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/mp070024d"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9203-2"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1021\/mp800026t"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.11.064"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.06.066"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/med.21403"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2015.02.025"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2006.11.007"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2012.08.002"},{"issue":"2","key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0022-3565(24)29254-5","volume":"299","author":"Batrakova E. V.","year":"2001","journal-title":"J. Pharmacol Exp Ther."},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.3.3001"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.3109\/03639049109043810"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1080\/01932698608943478"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/mp400643p"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1021\/bc200284b"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.10.061"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.07.043"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1002\/jps.10175"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9347-8"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-011-1114-z"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.12.028"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-011-1016-0"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00047-9"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21372"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.8b00482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:47:38Z","timestamp":1775245658000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.8b00482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,12]]},"references-count":75,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11,5]]}},"alternative-id":["10.1021\/acs.molpharmaceut.8b00482"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.8b00482","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,12]]}}}