{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:12:16Z","timestamp":1777525936267,"version":"3.51.4"},"reference-count":61,"publisher":"American Chemical Society (ACS)","issue":"11","funder":[{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009408","name":"Fondation Brain Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000032","name":"Institute of Infection and Immunity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006126","name":"Hospital for Sick Children","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006126","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2018,11,5]]},"DOI":"10.1021\/acs.molpharmaceut.8b00735","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T22:36:19Z","timestamp":1536878179000},"page":"5217-5226","source":"Crossref","is-referenced-by-count":20,"title":["Intracellular Delivery of Human Purine Nucleoside Phosphorylase by Engineered Diphtheria Toxin Rescues Function in Target Cells"],"prefix":"10.1021","volume":"15","author":[{"given":"Minyoung","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixian","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji N.","family":"Sugiman-Marangos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg L.","family":"Beilhartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarret J.","family":"Adams","sequence":"additional","affiliation":[{"name":"Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachdev S.","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Banting and Best Department of Medical Research, Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Grunebaum","sequence":"additional","affiliation":[{"name":"Division of Immunology and Allergy, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7187-2362","authenticated-orcid":true,"given":"Roman A.","family":"Melnyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2018,9,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2399"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-015-9833-6"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.11.077"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4389"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4236"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00233"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1081\/NCN-200027647"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000006"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.12.2197"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8380-9"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198010233031705"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.22.6853"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90623-K"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.101.2.548"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.1.172"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/298669a0"},{"issue":"15","key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"8817","DOI":"10.1016\/S0021-9258(17)39425-5","volume":"260","author":"Donovan J. J.","year":"1985","journal-title":"J. Biol. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/bi7025134"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.115.4.417"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900572"},{"issue":"17","key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"9068","DOI":"10.1016\/S0021-9258(19)52509-1","volume":"256","author":"Sandvig K.","year":"1981","journal-title":"J. Biol. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1084\/jem.120.6.1019"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(67)90280-X"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-8632-0_5"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-010-9123-8"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2006.07.003"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.11.037"},{"key":"ref29\/cit29","first-page":"495","volume-title":"Phage Display in Drug Discovery and Biotechnology","author":"Fellouse F. A.","year":"2017","edition":"2"},{"issue":"19","key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"9927","DOI":"10.1016\/S0021-9258(19)83606-2","volume":"254","author":"Lewis A. S.","year":"1979","journal-title":"J. Biol. Chem."},{"issue":"4","key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/S0021-9258(18)94403-0","volume":"244","author":"Agarwal R. P.","year":"1969","journal-title":"J. Biol. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(73)80840-3"},{"issue":"8","key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1128\/iai.60.8.3296-3302.1992","volume":"60","author":"Madshus I. H.","year":"1992","journal-title":"Infect. Immun."},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1042\/bj3130647"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05589.x"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00169"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.tb02375.x"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.3390\/toxins3030294"},{"issue":"1","key":"ref40\/cit40","first-page":"45","volume":"3","author":"Markert M. L.","year":"1991","journal-title":"Immunodefic Rev."},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1711.1999.00877.x"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(94)90236-4"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1139\/m77-026"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth762"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25052"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200201000-00018"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.06.075"},{"key":"ref48\/cit48","unstructured":"Grunebaum, E. Purine nucleoside phosphorylase deficiency. https:\/\/www.uptodate.com\/contents\/purine-nucleoside-phosphorylase-deficiency (accessed Jun 27, 2018)."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-017-0184-y"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00143"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.22.12531"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.1999.00890.x"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00201-13"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201402290"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.2000.1685"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.12.019"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00562"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.113.5.1025"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2000.n.009"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0487"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2670"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2014.10.003"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.8b00735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T09:25:42Z","timestamp":1682501142000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.8b00735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,13]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11,5]]}},"alternative-id":["10.1021\/acs.molpharmaceut.8b00735"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.8b00735","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,13]]}}}