{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:45:39Z","timestamp":1778885139749,"version":"3.51.4"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["DA038876"],"award-info":[{"award-number":["DA038876"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2019,6,3]]},"DOI":"10.1021\/acs.molpharmaceut.8b01296","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T22:30:36Z","timestamp":1556145036000},"page":"2364-2375","source":"Crossref","is-referenced-by-count":17,"title":["Formulation and Characterization of Conjugate Vaccines to Reduce Opioid Use Disorders Suitable for Pharmaceutical Manufacturing and Clinical Evaluation"],"prefix":"10.1021","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8259-1267","authenticated-orcid":true,"given":"F.","family":"Baruffaldi","sequence":"first","affiliation":[{"name":"Hennepin Healthcare Research Institute, Minneapolis, Minnesota 55404, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Raleigh","sequence":"additional","affiliation":[{"name":"Hennepin Healthcare Research Institute, Minneapolis, Minnesota 55404, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"King","sequence":"additional","affiliation":[{"name":"Hennepin Healthcare Research Institute, Minneapolis, Minnesota 55404, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Roslawski","sequence":"additional","affiliation":[{"name":"University of Minnesota College of Pharmacy, Minneapolis, Minnesota 55455, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"University of Minnesota College of Pharmacy, Minneapolis, Minnesota 55455, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hassler","sequence":"additional","affiliation":[{"name":"RTI International, Research Triangle Park, North Carolina 27709-2194, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9510-765X","authenticated-orcid":true,"given":"F. I.","family":"Carroll","sequence":"additional","affiliation":[{"name":"RTI International, Research Triangle Park, North Carolina 27709-2194, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Runyon","sequence":"additional","affiliation":[{"name":"RTI International, Research Triangle Park, North Carolina 27709-2194, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Winston","sequence":"additional","affiliation":[{"name":"Winston Biopharmaceutical Consulting, 4475 Laguna Place #215, Boulder, Colorado 80303, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. R.","family":"Pentel","sequence":"additional","affiliation":[{"name":"Hennepin Healthcare Research Institute, Minneapolis, Minnesota 55404, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1036-0184","authenticated-orcid":true,"given":"M.","family":"Pravetoni","sequence":"additional","affiliation":[{"name":"Hennepin Healthcare Research Institute, Minneapolis, Minnesota 55404, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6712a1"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","unstructured":"Overdose Deaths Involving Opioids, Cocaine, and Psychostimulants\u2014United\nStates. https:\/\/www.cdc.gov\/mmwr\/volumes\/67\/wr\/mm6712a1.htm?s_cid=mm6712a1_w, 2015\u20132016 (accessed 2018).","DOI":"10.15585\/mmwr.mm6712a1"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm655051e1"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.9308"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1212785"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-420118-7.00014-7"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500385"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.6b00977"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184876"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07502.x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b03334"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/252708a0"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.3923\/jpt.2009.30.35"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101807"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-014-8035-x"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096547"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.189506"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23777-6"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/jm3013745"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.8b00592"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.247049"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.201194"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.101"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201511654"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01427"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.2174\/187152711799219316"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/bc00031a015"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.317"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.128"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002547"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1300\/j069v23n04_01"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200402000-00020"},{"key":"ref33\/cit33","unstructured":"FDA\nGuidance for Industry. Sterile\nDrug Products Produced By\nAseptic Processing - Current Good Manufacturing Practice. https:\/\/www.gmp-compliance.org\/guidelines\/gmp-guideline\/fda-guidance-for-industry-sterile-drug-products-produced-by-aseptic-processing-current-good-manufacturing-practice-september-200, September 2004 (accessed 2018)."},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.10.080"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/iub.435"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3109\/1547691x.2013.821564"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1023\/b:pham.0000029275.41323.a6"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines5020011"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.09.012"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.02.030"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.2174\/157488610792246000"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.10.3671"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.5b00085"}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.molpharmaceut.8b01296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T02:20:08Z","timestamp":1682648408000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.molpharmaceut.8b01296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6,3]]}},"alternative-id":["10.1021\/acs.molpharmaceut.8b01296"],"URL":"https:\/\/doi.org\/10.1021\/acs.molpharmaceut.8b01296","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,24]]}}}