{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T20:06:07Z","timestamp":1794081967289,"version":"4.8.0"},"reference-count":34,"publisher":"American Chemical Society (ACS)","issue":"49","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["T32-ES007020"],"award-info":[{"award-number":["T32-ES007020"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021914","name":"Grand Challenges in Global Health","doi-asserted-by":"publisher","award":["6948010"],"award-info":[{"award-number":["6948010"]}],"id":[{"id":"10.13039\/100021914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MFE-187894"],"award-info":[{"award-number":["MFE-187894"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","award":["57555903"],"award-info":[{"award-number":["57555903"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01EB021908"],"award-info":[{"award-number":["R01EB021908"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM098117"],"award-info":[{"award-number":["R01GM098117"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nano Lett."],"published-print":{"date-parts":[[2025,12,10]]},"DOI":"10.1021\/acs.nanolett.5c02487","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:38:07Z","timestamp":1763746687000},"page":"16963-16969","source":"Crossref","is-referenced-by-count":11,"title":["Polymer Blend Controls Nanoparticles\u2019 Surface Charge for Improved Mucus Penetration and Epithelial Cell Adhesion"],"prefix":"10.1021","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9619-7869","authenticated-orcid":true,"given":"Corey A.","family":"Stevens","sequence":"first","affiliation":[{"name":"Department of Biological Engineering","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]},{"name":"Department of Biological Engineering, Koch Institute for Integrative Cancer Research","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8536-4302","authenticated-orcid":true,"given":"Boris","family":"Sevarika","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]},{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)","place":["Saarbr\u00fccken, Germany"]},{"name":"Helmholtz Centre for Infection Research (HZI)","place":["Saarbr\u00fccken, Germany"]},{"name":"Department of Pharmacy","place":["Saarbr\u00fccken, Germany"]},{"name":"Saarland University","place":["Saarbr\u00fccken, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian K.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering","place":["Princeton, United States"]},{"name":"Princeton University","place":["Princeton, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"C\u00e1rcamo-Oyarce","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Degen","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Kassis","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5864-8462","authenticated-orcid":true,"given":"Claus Michael","family":"Lehr","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)","place":["Saarbr\u00fccken, Germany"]},{"name":"Helmholtz Centre for Infection Research (HZI)","place":["Saarbr\u00fccken, Germany"]},{"name":"Department of Pharmacy","place":["Saarbr\u00fccken, Germany"]},{"name":"Saarland University","place":["Saarbr\u00fccken, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-7098","authenticated-orcid":true,"given":"Rebecca L.","family":"Carrier","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering","place":["Boston, United States"]},{"name":"Northeastern University","place":["Boston, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8260-338X","authenticated-orcid":true,"given":"Katharina","family":"Ribbeck","sequence":"additional","affiliation":[{"name":"Department of Biological Engineering","place":["Cambridge, United States"]},{"name":"Massachusetts Institute of Technology","place":["Cambridge, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2858-0097","authenticated-orcid":true,"given":"Robert K.","family":"Prud\u2019homme","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering","place":["Princeton, United States"]},{"name":"Princeton University","place":["Princeton, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00698-w"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100617-062818"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.88"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.07.038"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.11.002"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114966"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200803526"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201000137"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2010.01.012"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2016-0047"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.7b04674"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608611104"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-023-00552-2"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.3c02277"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00600-w"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600840420"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/marc.200300259"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22090"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3791\/67047"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1945-9"},{"key":"ref22\/cit22","unstructured":"Sealy, A.\n                      How Pfizer makes its millions of Covid-19 vaccine doses\n                      ; CNN, 2021."},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00217F"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.03.058"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201390"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1071\/CH03115"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.2c01016"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.09.001"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/ma0107758"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608582104"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c10381"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-022-00755-x"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-020-0669-6"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.12.001"}],"container-title":["Nano Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.nanolett.5c02487","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.nanolett.5c02487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:12:11Z","timestamp":1765357931000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.nanolett.5c02487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":34,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2025,12,10]]}},"alternative-id":["10.1021\/acs.nanolett.5c02487"],"URL":"https:\/\/doi.org\/10.1021\/acs.nanolett.5c02487","relation":{},"ISSN":["1530-6984","1530-6992"],"issn-type":[{"value":"1530-6984","type":"print"},{"value":"1530-6992","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]}}}