{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:59:17Z","timestamp":1781081957517,"version":"3.54.1"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"22","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005075","name":"Universitair Medisch Centrum Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014438","name":"Business Finland","doi-asserted-by":"publisher","award":["266\/31\/2025"],"award-info":[{"award-number":["266\/31\/2025"]}],"id":[{"id":"10.13039\/501100014438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014438","name":"Business Finland","doi-asserted-by":"publisher","award":["8873\/31\/2022"],"award-info":[{"award-number":["8873\/31\/2022"]}],"id":[{"id":"10.13039\/501100014438","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ELY Centres project","award":["HMELY\/00012\/05.02.09\/2023"],"award-info":[{"award-number":["HMELY\/00012\/05.02.09\/2023"]}]},{"name":"FinnCure Ltd."},{"name":"Runar B?ckstr?m foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nano Lett."],"published-print":{"date-parts":[[2026,6,10]]},"DOI":"10.1021\/acs.nanolett.5c05282","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T19:52:21Z","timestamp":1779479541000},"page":"7227-7234","source":"Crossref","is-referenced-by-count":0,"title":["Inhaled Virus-Mimicking Particles Elicit Dose-Dependent Immune Response against SARS-CoV-2 with Sex-Bias ACE2 Activity in Mice"],"prefix":"10.1021","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-7290","authenticated-orcid":true,"given":"Pei","family":"Zhang","sequence":"first","affiliation":[{"name":"Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy","place":["Helsinki, Finland"]},{"name":"University of Helsinki","place":["Helsinki, Finland"]},{"name":"Finncure Oy, Lars Sonckin Kaari 14, Espoo 02600, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Niemel\u00e4","sequence":"additional","affiliation":[{"name":"Finncure Oy, Lars Sonckin Kaari 14, Espoo 02600, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Filis","sequence":"additional","affiliation":[{"name":"Charles River Laboratories","place":["Tranent, United Kingdom"]},{"name":"Elphinstone Research Centre","place":["Tranent, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi","family":"Sorvisto","sequence":"additional","affiliation":[{"name":"Finncure Oy, Lars Sonckin Kaari 14, Espoo 02600, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jani","family":"Virtanen","sequence":"additional","affiliation":[{"name":"Finncure Oy, Lars Sonckin Kaari 14, Espoo 02600, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7850-6309","authenticated-orcid":true,"given":"H\u00e9lder A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Biomedical Technology, The Personalized Medicine Research Institute (PRECISION), University Medical Center Groningen, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00841-7"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44265-0"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00750-w"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27202-x"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26803-w"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104043"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2852-1"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01294-w"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.02.037"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2100362"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00573-0"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41661-4"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00402-5"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00393-6"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02007-8"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-021-00315-9"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abq8276"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c04430"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107470"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28359"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00138E"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2020.04.007"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/nature13118"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/nature05058"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.5b02797"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/la035864n"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2022.05.008"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401120"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1984.129.5.742"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201611-2268OC"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2102957118"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/978-94-011-6150-3_7","volume-title":"Immunological Aspects of the Liver and Gastrointestinal Tract","author":"Bj\u00f8rneboe M.","year":"1976"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-022-00902-5"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.01.020"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19891-7"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1005321"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.5c03021"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1177\/1074248420967792"}],"container-title":["Nano Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.nanolett.5c05282","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.nanolett.5c05282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:13:00Z","timestamp":1781079180000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.nanolett.5c05282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":38,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2026,6,10]]}},"alternative-id":["10.1021\/acs.nanolett.5c05282"],"URL":"https:\/\/doi.org\/10.1021\/acs.nanolett.5c05282","relation":{},"ISSN":["1530-6984","1530-6992"],"issn-type":[{"value":"1530-6984","type":"print"},{"value":"1530-6992","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]}}}