{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:42:14Z","timestamp":1786542134269,"version":"build-2736575974"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"31","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22375205"],"award-info":[{"award-number":["22375205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Directional Institutionalized Scientific Research Platform relies on Beijing Synchrotron Radiation Facility of Chinese Academy of Sciences","award":["E12982U810"],"award-info":[{"award-number":["E12982U810"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2025-PUMCH-A-029"],"award-info":[{"award-number":["2025-PUMCH-A-029"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2021YFA1201200"],"award-info":[{"award-number":["2021YFA1201200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFA1205900"],"award-info":[{"award-number":["2022YFA1205900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Technology Innovation Program of Institute of High Energy Physics","award":["Y9545130U2"],"award-info":[{"award-number":["Y9545130U2"]}]},{"name":"Beijing Natural Science Foundation","award":["2254101"],"award-info":[{"award-number":["2254101"]}]},{"name":"Beijing Natural Science Foundation","award":["L2602039"],"award-info":[{"award-number":["L2602039"]}]},{"name":"International Scientific Exchange Foundation of China","award":["SWYY2025003089"],"award-info":[{"award-number":["SWYY2025003089"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acquired radioresistance remains a major clinical obstacle in triple-negative breast cancer (TNBC) radiotherapy. Here, we first report the combined use of an ultrasmall copper-doped hafnium oxide nanoradiosensitizer (US-HfO2:Cu, \u223c10 nm) and 192Ir brachytherapy (BT) to address this issue. BT triggers radiation-responsive Cu+ release from US-HfO2:Cu, inducing intracellular copper overload and cuproptosis, while the high-Z HfO2 core enhances radiation energy deposition to aggravate DNA damage. This synergistic biophysical strategy impairs mitochondrial function and activates the cGAS-STING pathway, eliciting immunogenic cell death and robust systemic antitumor immunity. When combined with brachytherapy, US-HfO2:Cu efficiently suppresses primary tumor growth and inhibits distant tumor metastasis via the abscopal effect in the acquired radioresistant TNBC murine model, while minimizing damage to normal tissues. These findings establish a strategy integrating cuproptosis, physical radioenhancement, and immune activation to combat aggressive radioresistant TNBC, holding great clinical translation potential.<\/jats:p>","DOI":"10.1021\/acs.nanolett.6c02420","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:37:44Z","timestamp":1785854264000},"page":"10434-10445","source":"Crossref","is-referenced-by-count":0,"title":["Brachytherapy\nCombined with Cuproptosis-Inducing Radiosensitizer\nOvercomes Radioresistance in Triple-Negative Breast Cancer"],"prefix":"10.1021","volume":"26","author":[{"given":"Xue","family":"Wang","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglu","family":"Gu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, People\u2019s Republic of China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7751-8922","authenticated-orcid":true,"given":"Xihong","family":"Guo","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanglong","family":"Du","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, People\u2019s Republic of China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Luo","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, People\u2019s Republic of China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Yang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, People\u2019s Republic of China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Tian","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, People\u2019s Republic of China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, People\u2019s Republic of China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Yan","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College , , ,","place":["Beijing, People\u2019s Republic of China, 100730"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-4642","authenticated-orcid":true,"given":"Baoyun","family":"Sun","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3717-2423","authenticated-orcid":true,"given":"Zhanjun","family":"Gu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , ,","place":["Beijing, China, 100049"]},{"name":"University of Chinese Academy of Sciences , ,","place":["Beijing, China, 100049"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"issue":"1","key":"2026081209092879900_cit1","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/s41419-025-07873-w","article-title":"Molecular features of\nTNBC govern heterogeneity in the response to radiation and autophagy\ninhibition","volume":"16","author":"Fischer","year":"2025","journal-title":"Cell Death. Dis."},{"key":"2026081209092879900_cit2","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.radonc.2021.09.006","article-title":"Long term\nresults of a phase II trial of hypofractionated\nadjuvant radiotherapy for early-stage breast cancer with volumetric\nmodulated arc therapy and simultaneous integrated boost","volume":"164","author":"Franceschini","year":"2021","journal-title":"Radiother. Oncol."},{"issue":"1","key":"2026081209092879900_cit3","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1038\/s41598-023-29925-x","article-title":"Acquired radioresistance\nin EMT6\nmouse mammary carcinoma cell line is mediated by CTLA-4 and PD-1 through\nJAK\/STAT\/PI3K pathway","volume":"13","author":"Sham","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"2026081209092879900_cit4","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12943-023-01801-2","article-title":"Molecular mechanisms\nof tumor resistance to radiotherapy","volume":"22","author":"Wu","year":"2023","journal-title":"Mol. Cancer"},{"issue":"1","key":"2026081209092879900_cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2020.100640","article-title":"Reirradiation for\nLocoregional Recurrent Breast Cancer","volume":"6","author":"Fattahi","year":"2021","journal-title":"Adv. Radiat.\nOncol."},{"key":"2026081209092879900_cit6","doi-asserted-by":"publisher","first-page":"102351","DOI":"10.1016\/j.tranon.2025.102351","article-title":"Mechanisms\nof radioresistance and radiosensitization strategies for Triple Negative\nBreast Cancer","volume":"55","author":"Wang","year":"2025","journal-title":"Transl. Oncol."},{"issue":"6586","key":"2026081209092879900_cit7","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"issue":"6","key":"2026081209092879900_cit8","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1016\/j.ccell.2025.03.031","article-title":"Radiotherapy\npromotes cuproptosis and synergizes with cuproptosis inducers to overcome\ntumor radioresistance","volume":"43","author":"Lei","year":"2025","journal-title":"Cancer Cell"},{"issue":"12","key":"2026081209092879900_cit9","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1038\/s41565-024-01784-1","article-title":"A cuproptosis\nnanocapsule for cancer radiotherapy","volume":"19","author":"Liao","year":"2024","journal-title":"Nat. Nanotechnol."},{"issue":"2","key":"2026081209092879900_cit10","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1021\/acsnano.3c08917","article-title":"Synthesis\nand bioapplication of emerging nanomaterials of hafnium","volume":"18","author":"Skrodzki","year":"2024","journal-title":"ACS Nano"},{"issue":"8","key":"2026081209092879900_cit11","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/S1470-2045(19)30326-2","article-title":"NBTXR3, a first-in-class radioenhancer hafnium\noxide nanoparticle, plus radiotherapy versus radiotherapy alone in\npatients with locally advanced soft-tissue sarcoma (Act.In.Sarc):\na multicentre, phase 2\u20133, randomised, controlled trial","volume":"20","author":"Bonvalot","year":"2019","journal-title":"Lancet Oncol."},{"issue":"6","key":"2026081209092879900_cit12","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1002\/hed.27739","article-title":"International\nguidelines\nfor intratumoral and intranodal injection of NBTXR3 nanoparticles\nin head and neck cancers","volume":"46","author":"Liem","year":"2024","journal-title":"Head Neck"},{"issue":"6","key":"2026081209092879900_cit13","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S1470-2045(18)30253-5","article-title":"Quality of\nlife after multicatheter breast brachytherapy","volume":"19","author":"Jagsi","year":"2018","journal-title":"Lancet Oncol."},{"key":"2026081209092879900_cit14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.addr.2016.09.002","article-title":"Advancements in brachytherapy","volume":"109","author":"Tanderup","year":"2017","journal-title":"Adv. Drug Delivery Rev."},{"issue":"5","key":"2026081209092879900_cit15","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3322\/caac.21578","article-title":"Brachytherapy: an overview for clinicians","volume":"69","author":"Chargari","year":"2019","journal-title":"CA-Cancer J. Clin."},{"issue":"6","key":"2026081209092879900_cit16","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.brachy.2023.07.004","article-title":"Reirradiation with advanced brachytherapy techniques\nin recurrent GYN cancers","volume":"22","author":"Mahantshetty","year":"2023","journal-title":"Brachytherapy"},{"issue":"4","key":"2026081209092879900_cit17","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1001\/jamaoncol.2019.5882","article-title":"Brachytherapy","volume":"6","author":"Dalwadi","year":"2020","journal-title":"JAMA Oncol."},{"key":"2026081209092879900_cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2023.341352","article-title":"3D-imaging and quantitative assessment for size-related penetration\nof HfO2 nanoparticles in breast cancer tumor by synchrotron radiation\nmicrocomputed tomography","volume":"1266","author":"Wang","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"2026081209092879900_cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101997","article-title":"Ultra-small\nradiosensitizers deliver epigenetic drugs to induce pyroptosis and\nboost triple-negative breast cancer radiotherapy","volume":"52","author":"Liu","year":"2023","journal-title":"Nano Today"},{"issue":"4","key":"2026081209092879900_cit20","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1007\/s42864-024-00279-9","article-title":"Preparation of water-soluble\ntantalum nanoparticles and their radiosensitization application","volume":"6","author":"Zhang","year":"2024","journal-title":"Tungsten"},{"issue":"3","key":"2026081209092879900_cit21","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1021\/acs.nanolett.8b04763","article-title":"Tumor Microenvironment-Responsive\nCu2(OH)PO4 Nanocrystals for Selective\nand Controllable Radiosentization via the X-ray-Triggered Fenton-like\nReaction","volume":"19","author":"Zhang","year":"2019","journal-title":"Nano Lett."},{"key":"2026081209092879900_cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102626","article-title":"Hafnium oxide-based\nsensitizer with radiation-triggered cuproptosis for radiotherapy","volume":"61","author":"Wang","year":"2025","journal-title":"Nano Today"},{"issue":"1","key":"2026081209092879900_cit23","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1021\/acs.jpcc.6b10835","article-title":"Mechanistic Study of\nCO2 Photoreduction with H2O on Cu\/TiO2 Nanocomposites by in Situ X-ray\nAbsorption and Infrared Spectroscopies","volume":"121","author":"Liu","year":"2017","journal-title":"Phys.\nChem. C"},{"issue":"45","key":"2026081209092879900_cit24","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202410031","article-title":"A Nucleophilicity-Engineered\nDNA Ligation Blockade Nanoradiosensitizer Induces Irreversible DNA\nDamage to Overcome Cancer Radioresistance","volume":"36","author":"Yang","year":"2024","journal-title":"Adv.\nMater."},{"issue":"29","key":"2026081209092879900_cit25","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202313991","article-title":"Manipulating Radiation-Sensitive Z-DNA Conformation for Enhanced\nRadiotherapy","volume":"36","author":"Wang","year":"2024","journal-title":"Adv. Mater."},{"issue":"1","key":"2026081209092879900_cit26","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1021\/ja055064u","article-title":"A Selective\nTurn-On Fluorescent Sensor for Imaging Copper in Living Cells","volume":"128","author":"Zeng","year":"2006","journal-title":"J. Am. Chem. Soc."},{"issue":"7","key":"2026081209092879900_cit27","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202410606","article-title":"Graphene Quantum Dot\nSensitized Heterojunctions Induce\nTumor-Specific Cuproptosis to Boost Sonodynamic and Chemodynamic Enhanced\nCancer Immunotherapy","volume":"12","author":"Yan","year":"2025","journal-title":"Adv. Sci."},{"issue":"10","key":"2026081209092879900_cit28","doi-asserted-by":"publisher","first-page":"3988","DOI":"10.1021\/jacsau.4c00712","article-title":"Signaling\nMechanism of Cuproptosis Activating cGAS-STING Immune Pathway","volume":"4","author":"Zhu","year":"2024","journal-title":"JACS Au"},{"key":"2026081209092879900_cit29","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.radonc.2019.07.029","article-title":"DNA damage enhancement by radiotherapy-activated\nhafnium oxide nanoparticles improves cGAS-STING pathway activation\nin human colorectal cancer cells","volume":"141","author":"Marill","year":"2019","journal-title":"Radiother.\nOncol."},{"key":"2026081209092879900_cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122512","article-title":"Cuproptotic nanoinducer-driven proteotoxic\nstress potentiates cancer immunotherapy by activating the mtDNA-cGAS-STING\nsignaling","volume":"307","author":"Yu","year":"2024","journal-title":"Biomaterials"},{"issue":"51","key":"2026081209092879900_cit31","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202306584","article-title":"Clinical Chemotherapeutic\nAgent Coordinated Copper-Based Nanoadjuvants for Efficiently Sensitizing\nCancer Chemo-Immunotherapy by Cuproptosis-Mediated Mitochondrial Metabolic\nReprogramming","volume":"33","author":"Tian","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"25","key":"2026081209092879900_cit32","doi-asserted-by":"publisher","first-page":"e19998","DOI":"10.1002\/adfm.202519998","article-title":"Zr-Based Metal\u2013Organic\nFramework Dual-Sensitized by Carbon Dot Sonosensitizers and MnO2\u2013x\nNanozymes for cGAS-STING Activation Enhanced Sonocatalytic-Immunotherapy","volume":"36","author":"Xiao","year":"2026","journal-title":"Adv. Funct. Mater."},{"issue":"4","key":"2026081209092879900_cit33","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202003458","article-title":"Second Near-Infrared Photothermal Semiconducting Polymer Nanoadjuvant\nfor Enhanced Cancer Immunotherapy","volume":"33","author":"Li","year":"2021","journal-title":"Adv. Mater."},{"issue":"28","key":"2026081209092879900_cit34","doi-asserted-by":"publisher","DOI":"10.1002\/adma.73080","article-title":"Dynamically Crosslinked\nCarbon Dot\/Alginate Hydrogels for On-Demand Osteomyelitis Therapy","volume":"38","author":"Wang","year":"2026","journal-title":"Adv. Mater."},{"key":"2026081209092879900_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2026.123987","article-title":"Atomic-valence engineering\nof a Mn(III)-tuned sonozyme system for multimodal tumor immunotherapy","volume":"329","author":"Hu","year":"2026","journal-title":"Biomaterials"},{"issue":"1","key":"2026081209092879900_cit36","doi-asserted-by":"publisher","first-page":"4756","DOI":"10.1038\/s41467-026-71476-y","article-title":"D-pi-A sensitized carbon\ndots as long-lived type-I\/II photosensitizers for NIR-excited hypoxia-regulated\nphotodynamic therapy","volume":"17","author":"Zhang","year":"2026","journal-title":"Nat. Commun."}],"container-title":["Nano Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.nanolett.6c02420","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/nalefd\/article-pdf\/26\/31\/10434\/66354713\/acs.nanolett.6c02420.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/nalefd\/article-pdf\/26\/31\/10434\/66354713\/acs.nanolett.6c02420.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:21:34Z","timestamp":1786540894000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/nalefd\/article\/26\/31\/10434\/5238340\/Brachytherapy-Combined-with-Cuproptosis-Inducing"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,2]]},"references-count":36,"journal-issue":{"issue":"31","published-online":{"date-parts":[[2026,8,2]]},"published-print":{"date-parts":[[2026,8,12]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.nanolett.6c02420","relation":{},"ISSN":["1530-6984","1530-6992"],"issn-type":[{"value":"1530-6984","type":"print"},{"value":"1530-6992","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,2]]}}}