{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:25:35Z","timestamp":1787153135954,"version":"build-2736575974"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"32","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intervertebral disc degeneration (IVDD) is a global challenge to cure effectively. Although current hydrogel-based therapies are promising, they often have difficulty of completely reversing IVDD progression. Herein, we report an injectable and growth factor-laden hydrogel foam (IHFs@GFs) for the treatment of IVDD. IHF is prepared from methylphenyltetrazine-modified hyaluronic acid (HA-MTZ), norbornene-modified gelatin (Gelatin-NB), and norbornene-modified cellulose nanofibers (CNF-NB). MTZ reacts with NB to release N2, spontaneously generating numerous closed and spherical N2 bubbles in hydrogels. These N2 bubbles endow IHF with good mechanical resilience and pressure buffering. Moreover, IHF shows zero-order release of transforming growth factor-\u03b23 and insulin-like growth factor-1. Notably, after 8 weeks of treatment with IHFs@GFs, the disc height and hydration in degenerated IVD are significantly restored to over 90%, thereby enabling effective treatment of IVDD. The IHF integrates biomechanics and zero-order release of biologics within a single system, offering a promising platform for IVDD treatment.<\/jats:p>","DOI":"10.1021\/acs.nanolett.6c02554","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T12:01:36Z","timestamp":1786104096000},"page":"10792-10801","source":"Crossref","is-referenced-by-count":0,"title":["An Injectable\nHydrogel Foam Enables Mechanical Resilience\nand Zero-Order Release of Growth Factors for Intervertebral Disc Repair"],"prefix":"10.1021","volume":"26","author":[{"given":"Guoyong","family":"Han","sequence":"first","affiliation":[{"name":"Jilin University , , 2699 Qianjin Street , ,","place":["Changchun, China, 130012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Jilin University , , No. 126, Xiantai Street , , ,","place":["Changchun, Jilin, China, 130000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Dou","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , No. 112 Longhu Zhonghuan North Road , Jinshui District, , ,","place":["Zhengzhou, Henan Province, China, 450000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-8183","authenticated-orcid":true,"given":"Dianpeng","family":"Qi","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , No. 112 Longhu Zhonghuan North Road , Jinshui District, , ,","place":["Zhengzhou, Henan Province, China, 450000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3873-075X","authenticated-orcid":true,"given":"Bai","family":"Yang","sequence":"additional","affiliation":[{"name":"Jilin University , , 2699 Qianjin Street , ,","place":["Changchun, China, 130012"]},{"name":"The First Hospital of Jilin University , , ,","place":["Changchun, China, 130021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Jilin University , , No. 126, Xiantai Street , , ,","place":["Changchun, Jilin, China, 130000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gu","sequence":"additional","affiliation":[{"name":"Jilin University , , No. 126, Xiantai Street , , ,","place":["Changchun, Jilin, China, 130000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6520-8561","authenticated-orcid":true,"given":"Yunfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Jilin University , , 2699 Qianjin Street , ,","place":["Changchun, China, 130012"]},{"name":"The First Hospital of Jilin University , , ,","place":["Changchun, China, 130021"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"issue":"14","key":"2026081910195932700_cit1","doi-asserted-by":"publisher","first-page":"2310416","DOI":"10.1002\/adfm.202310416","article-title":"Injectable Dynamic\nHydrogel with Responsive Mechanical Reinforcing Ability Reverses Intervertebral\nDisc Degeneration by Suppressing Ferroptosis and Restoring Matrix\nHomeostasis","volume":"34","author":"Wang","year":"2024","journal-title":"Adv. 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Rheumatol."},{"issue":"13","key":"2026081910195932700_cit12","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abk0011","article-title":"Stem Cell\u2013Homing\nHydrogel-Based\nMiR-29b-5p Delivery Promotes Cartilage Regeneration by Suppressing\nSenescence in an Osteoarthritis Rat Model","volume":"8","author":"Zhu","year":"2022","journal-title":"Sci.\nAdv."},{"key":"2026081910195932700_cit13","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1038\/s41591-020-1013-2","article-title":"Articular\nCartilage Regeneration by Activated Skeletal Stem Cells","volume":"26","author":"Murphy","year":"2020","journal-title":"Nat. Med."},{"key":"2026081910195932700_cit14","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/nrrheum.2015.13","article-title":"Stem Cell Therapy for Intervertebral\nDisc Regeneration:\nObstacles and Solutions","volume":"11","author":"Sakai","year":"2015","journal-title":"Nat. Rev. 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Res."},{"key":"2026081910195932700_cit25","doi-asserted-by":"publisher","first-page":"5460","DOI":"10.1038\/s41467-024-49578-2","article-title":"Superporous Sponge\nPrepared by Secondary Network Compaction with\nEnhanced Permeability and Mechanical Properties for Non-Compressible\nHemostasis in Pigs","volume":"15","author":"Jiang","year":"2024","journal-title":"Nat. Commun."},{"issue":"15","key":"2026081910195932700_cit26","doi-asserted-by":"publisher","first-page":"2308701","DOI":"10.1002\/adma.202308701","article-title":"Injectable Self-Expanding\/Self-Propelling\nHydrogel Adhesive with\nProcoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage\nManagement","volume":"36","author":"Zhao","year":"2024","journal-title":"Adv. Mater."},{"issue":"24","key":"2026081910195932700_cit27","doi-asserted-by":"publisher","first-page":"2300636","DOI":"10.1002\/adma.202300636","article-title":"Coacervation-Mediated\nCytocompatible Formation of Supramolecular Hydrogels with Self-Evolving\nMacropores for 3D Multicellular Spheroid Culture","volume":"35","author":"Yang","year":"2023","journal-title":"Adv. Mater."},{"key":"2026081910195932700_cit28","doi-asserted-by":"publisher","first-page":"202531295","DOI":"10.1002\/adfm.202531295","article-title":"Piezocatalytic H2-Evolving Gradient-Porous\nAntibacterial Hydrogel\nFoam for Electrotherapy of Infected Pressure Ulcers","volume":"36","author":"He","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"2026081910195932700_cit29","doi-asserted-by":"publisher","first-page":"11253","DOI":"10.1038\/s41467-025-66116-w","article-title":"Targeting the ROS-Ferroptosis-Inflammation\nCycle with a Nanozyme-Functionalized Hydrogel for Intervertebral Disc\nRepair","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"2026081910195932700_cit30","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1038\/s41467-024-45764-4","article-title":"Elastic Porous\nMicrospheres\/Extracellular\nMatrix Hydrogel Injectable Composites Releasing Dual Bio-Factors Enable\nTissue Regeneration","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"key":"2026081910195932700_cit31","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s40820-025-01830-0","article-title":"Nonswelling Lubricative\nNanocolloidal Hydrogel Resistant to Biodegradation","volume":"17","author":"Ding","year":"2025","journal-title":"Nano-Micro Lett."},{"issue":"21","key":"2026081910195932700_cit32","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202504424","article-title":"Nanocolloidal Hydrogel Coatings with Multiple Functions for Antithrombogenic\nBiointerfaces","volume":"15","author":"Ding","year":"2026","journal-title":"Adv. Healthc. 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Monit."},{"key":"2026081910195932700_cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122509","article-title":"Injectable\nPathological Microenvironment-Responsive Anti-Inflammatory Hydrogels\nfor Ameliorating Intervertebral Disc Degeneration","volume":"306","author":"Liu","year":"2024","journal-title":"Biomaterials"},{"key":"2026081910195932700_cit36","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202502205","article-title":"Mussel Foot Protein Membrane-Enclosed\nCrystalline Drug with Zero-Order Release Kinetics for Long-Acting\nTherapy","volume":"64","author":"Lu","year":"2025","journal-title":"Angew. Chem., Int. Ed."},{"key":"2026081910195932700_cit37","doi-asserted-by":"publisher","first-page":"16071","DOI":"10.1038\/natrevmats.2016.71","article-title":"Designing Hydrogels\nfor Controlled Drug Delivery","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"2026081910195932700_cit38","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.jconrel.2020.09.020","article-title":"Zero-Order\nDrug Delivery: State of\nthe Art and Future Prospects","volume":"327","author":"Laracuente","year":"2020","journal-title":"J. Controlled\nRelease"},{"key":"2026081910195932700_cit39","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jconrel.2020.06.033","article-title":"Oral Hydrophilic\nMatrices Having Non Uniform Drug Distribution for Zero-Order Release:\nA Literature Review","volume":"325","author":"Cerea","year":"2020","journal-title":"J. Controlled Release"},{"issue":"29","key":"2026081910195932700_cit40","doi-asserted-by":"publisher","first-page":"2400431","DOI":"10.1002\/adfm.202400431","article-title":"Bioprinting Macroporous\nHydrogel with Aqueous Two-Phase Emulsion-Based\nBioink: In Vitro Mineralization and Differentiation Empowered by Phosphorylated\nCellulose Nanofibrils","volume":"34","author":"Wang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"2026081910195932700_cit41","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ijsolstr.2015.02.034","article-title":"Effect of Entrapped\nGas on the Dynamic Compressive Behaviour of Cellular\nSolids","volume":"63","author":"Sun","year":"2015","journal-title":"Int. J. Solids Struct."},{"issue":"6","key":"2026081910195932700_cit42","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S0079-6425(00)00002-5","article-title":"Manufacture,\nCharacterisation and Application of Cellular Metals and Metal Foams","volume":"46","author":"Banhart","year":"2001","journal-title":"Prog. Mater. 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