{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:38:59Z","timestamp":1792593539920,"version":"4.5.0"},"reference-count":123,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001775","name":"University of Technology Sydney","doi-asserted-by":"publisher","award":["PRO22-15457"],"award-info":[{"award-number":["PRO22-15457"]}],"id":[{"id":"10.13039\/501100001775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2025442"],"award-info":[{"award-number":["2025442"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["106628"],"award-info":[{"award-number":["106628"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Preeclampsia originates in placental dysfunction yet it is detected only after maternal hypertension and proteinuria or other organ damage emerge, by which point disease-modifying interventions are not available, and delivery of the baby and placenta remains the only cure. Nanotechnology offers a route to reduce this diagnostic-therapeutic latency. Nanostructured biosensors and liquid biopsy platforms detect placental proteins, cell-free RNA\/DNA, and extracellular vesicles at femtomolar concentrations and in a multiplex manner, enabling earlier risk stratification when integrated with machine-learning models. In parallel, placenta-targeted lipid-, peptide-, polymeric-, dendrimeric-, and small extracellular vesicle-based nanocarriers deliver angiogenic mRNA, antiangiogenic siRNA, antioxidants, and immunomodulators selectively to the trophoblast cells while limiting fetal exposure. Placenta-on-a-chip platforms and ex vivo placental perfusion models provide human-relevant test beds for these systems. We critically appraise these advances, examine the safety-by-design, manufacturing bottlenecks, and regulatory constraints unique to obstetric nanomedicine, and outline the convergence of theranostics and digital health that could move preeclampsia care from reactive symptom management toward proactive, placenta-targeted monitoring and therapy.<\/jats:p>","DOI":"10.1021\/acs.nanolett.6c02855","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:01:59Z","timestamp":1788782519000},"page":"14061-14079","source":"Crossref","is-referenced-by-count":0,"title":["Nanotechnology-Driven\nPrecision Diagnostics and Therapeutics\nfor Preeclampsia"],"prefix":"10.1021","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7611-0943","authenticated-orcid":true,"given":"Iman","family":"Akbarzadeh","sequence":"first","affiliation":[{"name":"University of Technology Sydney , , , ,","place":["Sydney, New South Wales, Australia, 2007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serah Onyinyechi","family":"Nwoke","sequence":"additional","affiliation":[{"name":"University of Technology Sydney , , , ,","place":["Sydney, New South Wales, Australia, 2007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0616-4762","authenticated-orcid":true,"given":"Jiayan","family":"Liao","sequence":"additional","affiliation":[{"name":"University of Technology Sydney , , , ,","place":["Sydney, New South Wales, Australia, 2007"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-1014","authenticated-orcid":true,"given":"Lana","family":"McClements","sequence":"additional","affiliation":[{"name":"University of Technology Sydney , , , ,","place":["Sydney, New South Wales, Australia, 2007"]},{"name":"University of Technology Sydney , , , ,","place":["Sydney, New South Wales, Australia, 2007"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"2026102109270432500_cit1","unstructured":"Maternal Mortality; https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/maternal-mortality; World Health Organization, 2025."},{"issue":"1","key":"2026102109270432500_cit2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nature Reviews\nDisease primers"},{"key":"2026102109270432500_cit3","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.preghy.2021.09.008","article-title":"The 2021 International\nSociety for\nthe Study of Hypertension in Pregnancy classification, diagnosis &\nmanagement recommendations for international practice","volume":"27","author":"Magee","year":"2022","journal-title":"Pregnancy Hypertension"},{"key":"2026102109270432500_cit4","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/s41581-026-01085-x","article-title":"The pathophysiology\nof pre-eclampsia","volume":"22","author":"Hennessy","year":"2026","journal-title":"Nature Reviews Nephrology"},{"issue":"7","key":"2026102109270432500_cit5","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.125.26316","article-title":"Angiogenic\nImbalance\nModels of Preeclampsia: From Mechanisms to Clinics","volume":"83","author":"Akbarzadeh","year":"2026","journal-title":"Hypertension"},{"key":"2026102109270432500_cit6","doi-asserted-by":"publisher","first-page":"101054","DOI":"10.1016\/j.ajpc.2025.101054","article-title":"Preeclampsia: Insights into pathophysiological\nmechanisms and preventive\nstrategies","volume":"23","author":"Martini","year":"2025","journal-title":"American Journal of Preventive Cardiology"},{"issue":"3","key":"2026102109270432500_cit7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1177\/1753495X251327462","article-title":"Placental\ngrowth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt1):\npowerful new tools to guide obstetric and medical care in pregnancy","volume":"18","author":"Gladstone","year":"2025","journal-title":"Obstetric Medicine"},{"issue":"9","key":"2026102109270432500_cit8","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41574-020-0372-6","article-title":"Tracking placental\ndevelopment in health and disease","volume":"16","author":"Aplin","year":"2020","journal-title":"Nature Reviews\nEndocrinology"},{"issue":"3","key":"2026102109270432500_cit9","doi-asserted-by":"publisher","first-page":"312","DOI":"10.3390\/biom15030312","article-title":"Molecular\nBiomarkers for Timely and\nPersonalized Prediction of Maternal-Fetal Health Risk","volume":"15","author":"Estrela","year":"2025","journal-title":"Biomolecules"},{"issue":"1","key":"2026102109270432500_cit10","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3390\/bios13010040","article-title":"Nanotechnology-enabled\nbiosensors: a review of fundamentals, design principles, materials,\nand applications","volume":"13","author":"Ramesh","year":"2023","journal-title":"Biosensors"},{"issue":"41","key":"2026102109270432500_cit11","doi-asserted-by":"publisher","first-page":"2300852","DOI":"10.1002\/smll.202300852","article-title":"Rational\ndesign of nanomedicine for\nplacental disorders: birthing a new era in women\u2019s reproductive\nhealth","volume":"20","author":"Geisler","year":"2023","journal-title":"Small"},{"key":"2026102109270432500_cit12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jconrel.2023.06.003","article-title":"Nanomedicines: An approach to treat\nplacental insufficiency and the current challenges","volume":"360","author":"Van Kammen","year":"2023","journal-title":"J. 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