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Here, we report a serendipitous finding that during femtosecond two-photon microscopy, a microsecond-scale prolonged luminescence (\u201ccomet tail\u201d) is observed, whereas it is absent or greatly reduced under confocal continuous-wave excitation. We found that the decay time constant of the comet tail is typically 2\u20135 \u03bcs, remains temperature-independent from 0\u201337 \u00b0C, increases with laser power, and decreases with the decay time constant of the particle\u2019s temperature when varying the embedding medium. We further measured the absorption cross section for ZnS microparticles, and the photothermal modeling suggests that while femtosecond pulsed excitation results in instantaneous heating of electrons, it does not lead to a greater increase in bulk temperature in ZnS compared with continuous-wave excitation. Our findings bring new understanding and perspectives to mechanoluminescent particles-based imaging technologies and applications.<\/jats:p>","DOI":"10.1021\/acs.nanolett.6c02898","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:06:16Z","timestamp":1785128776000},"page":"9989-9994","source":"Crossref","is-referenced-by-count":2,"title":["Two-Photon\nExcited Luminescence in Mechanoluminescent\nZnS Microparticles"],"prefix":"10.1021","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1679-2775","authenticated-orcid":true,"given":"Alexandro I.","family":"DeAnda","sequence":"first","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xie","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marigold G.","family":"Malinao","sequence":"additional","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]},{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Stolarczyk","sequence":"additional","affiliation":[{"name":"UR 7548, University of Reims Champagne-Ardenne , , ,","place":["Reims, France, 51687 Cedex 2"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6171-9970","authenticated-orcid":true,"given":"Jaona H.","family":"Randrianalisoa","sequence":"additional","affiliation":[{"name":"UR 7548, University of Reims Champagne-Ardenne , , ,","place":["Reims, France, 51687 Cedex 2"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8858-4471","authenticated-orcid":true,"given":"Guosong","family":"Hong","sequence":"additional","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]},{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3406-3045","authenticated-orcid":true,"given":"Zhenpeng","family":"Qin","sequence":"additional","affiliation":[{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]},{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]},{"name":"University of Texas at Southwestern Medical Center , , , ,","place":["Dallas, Texas, United States, 75235"]},{"name":"University of Texas at Dallas , , , ,","place":["Richardson, Texas, United States, 75080"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"issue":"200","key":"2026080510134068900_cit1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-319-17659-8","article-title":"Ultrashort pulse laser technology","volume":"195","author":"Nolte","year":"2016","journal-title":"Springer Series in Optical Sciences"},{"issue":"1","key":"2026080510134068900_cit2","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/s41377-022-00904-7","article-title":"Fundamentals and comprehensive insights\non pulsed laser\nsynthesis of advanced materials for diverse photo- and electrocatalytic\napplications","volume":"11","author":"Theerthagiri","year":"2022","journal-title":"Light: Science & Applications"},{"key":"2026080510134068900_cit3","doi-asserted-by":"publisher","first-page":"663","DOI":"10.5772\/13095","article-title":"Ultrashort laser pulses\napplications","author":"Samad","year":"2010","journal-title":"IntechOpen"},{"issue":"3","key":"2026080510134068900_cit4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/j.1365-2818.2011.03532.x","article-title":"A simple introduction\nto multiphoton microscopy","volume":"243","author":"Ustione","year":"2011","journal-title":"J. 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Lumin."},{"key":"2026080510134068900_cit44","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.commatsci.2019.03.016","article-title":"Defect energy\nlevels and persistent\nluminescence in Cu-doped ZnS","volume":"163","author":"Hoang","year":"2019","journal-title":"Comput. 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